Search Results - "Di Trani, Justin M."

Structure of mycobacterial CIII2CIV2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203) by Yanofsky, David J, Di Trani, Justin M, Król, Sylwia, Abdelaziz, Rana, Bueler, Stephanie A, Imming, Peter, Brzezinski, Peter, Rubinstein, John L

“…The imidazopyridine telacebec, also known as Q203, is one of only a few new classes of compounds in more than 50 years with demonstrated antituberculosis…”
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Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III by Di Trani, Justin M., Liu, Zhongle, Whitesell, Luke, Brzezinski, Peter, Cowen, Leah E., Rubinstein, John L.

“…Electron transfer between respiratory complexes drives transmembrane proton translocation, which powers ATP synthesis and membrane transport. The homodimeric…”
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Electron transfer in the respiratory chain at low salinity by Lobez, Ana Paula, Wu, Fei, Di Trani, Justin M., Rubinstein, John L., Oliveberg, Mikael, Brzezinski, Peter, Moe, Agnes

“…Recent studies have established that cellular electrostatic interactions are more influential than assumed previously. Here, we use cryo-EM and perform…”
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Inhibition and Activation of Kinases by Reaction Products: A Reporter-Free Assay by Wang, Yun, Guan, Jinming, Di Trani, Justin M, Auclair, Karine, Mittermaier, Anthony K

“…Kinases are widely distributed in nature and are implicated in many human diseases. Thus, an understanding of their activity and regulation is of fundamental…”
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Rapid measurement of inhibitor binding kinetics by isothermal titration calorimetry by Di Trani, Justin M., De Cesco, Stephane, O’Leary, Rebecca, Plescia, Jessica, do Nascimento, Claudia Jorge, Moitessier, Nicolas, Mittermaier, Anthony K.

“…Although drug development typically focuses on binding thermodynamics, recent studies suggest that kinetic properties can strongly impact a drug candidate’s…”
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Measuring Rapid Time-Scale Reaction Kinetics Using Isothermal Titration Calorimetry by Di Trani, Justin M, Moitessier, Nicolas, Mittermaier, Anthony K

“…Isothermal titration calorimetry (ITC) is a powerful tool for acquiring both thermodynamic and kinetic data for biological interactions including molecular…”
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Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP by Harkness, Robert W., Ripstein, Zev A., Di Trani, Justin M., Kay, Lewis E.

“…The periplasmic protein DegP, which is implicated in virulence factor transport leading to pathogenicity, is a bi-functional protease and chaperone that helps…”
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Shake‐it‐off: a simple ultrasonic cryo‐EM specimen‐preparation device by Rubinstein, John L., Guo, Hui, Ripstein, Zev A., Haydaroglu, Ali, Au, Aaron, Yip, Christopher M., Di Trani, Justin M., Benlekbir, Samir, Kwok, Timothy

“…Although microscopes and image‐analysis software for electron cryomicroscopy (cryo‐EM) have improved dramatically in recent years, specimen‐preparation methods…”
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Complete Kinetic Characterization of Enzyme Inhibition in a Single Isothermal Titration Calorimetric Experiment by Di Trani, Justin M, Moitessier, Nicolas, Mittermaier, Anthony K

“…Techniques for rapidly measuring both the strength and mode of enzyme inhibitors are crucial to lead generation and optimization in drug development…”
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Structure of the bc1-cbb3 respiratory supercomplex from Pseudomonas aeruginosa by Di Trani, Justin M, Gheorghita, Andreea A, Turner, Madison, Brzezinski, Peter, Ädelroth, Pia, Vahidi, Siavash, Howell, P Lynne, Rubinstein, John L

“…Energy conversion by electron transport chains occurs through the sequential transfer of electrons between protein complexes and intermediate electron…”
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Structural basis of mammalian complex IV inhibition by steroids by Di Trani, Justin M, Moe, Agnes, Riepl, Daniel, Saura, Patricia, Kaila, Ville R I, Brzezinski, Peter, Rubinstein, John L

“…The mitochondrial electron transport chain maintains the proton motive force that powers adenosine triphosphate (ATP) synthesis. The energy for this process…”
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Structure of the bc 1 - cbb 3 respiratory supercomplex from Pseudomonas aeruginosa by Di Trani, Justin M, Gheorghita, Andreea A, Turner, Madison, Brzezinski, Peter, Ädelroth, Pia, Vahidi, Siavash, Howell, P Lynne, Rubinstein, John L

“…Energy conversion by electron transport chains occurs through the sequential transfer of electrons between protein complexes and intermediate electron…”
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High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles by Coupland, Claire E, Karimi, Ryan, Bueler, Stephanie A, Liang, Yingke, Courbon, Gautier M, Di Trani, Justin M, Wong, Cassandra J, Saghian, Rayan, Youn, Ji-Young, Wang, Lu-Yang, Rubinstein, John L

“…Intercellular communication in the nervous system occurs through the release of neurotransmitters into the synaptic cleft between neurons. In the presynaptic…”
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Structure of mycobacterial CIII 2 CIV 2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec (Q203) by Yanofsky, David J, Di Trani, Justin M, Król, Sylwia, Abdelaziz, Rana, Bueler, Stephanie A, Imming, Peter, Brzezinski, Peter, Rubinstein, John L

“…The imidazopyridine telacebec, also known as Q203, is one of only a few new classes of compounds in more than 50 years with demonstrated antituberculosis…”
Get full text

Imidazopyridine Amides: Synthesis, Mycobacterium smegmatis CIII2CIV2 Supercomplex Binding, and In Vitro Antimycobacterial Activity by Abdelaziz, Rana, Di Trani, Justin M, Sahile, Henok, Mann, Lea, Richter, Adrian, Liu, Zhongle, Bueler, Stephanie A., Cowen, Leah E., Rubinstein, John L., Imming, Peter

“…Q203 (telacebec) is an imidazopyridine amide (IPA) targeting the respiratory CIII2CIV2 supercomplex of the mycobacterial electron transport chain (ETC). Aiming…”
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Structure of the bc1–cbb3 respiratory supercomplex from Pseudomonas aeruginosa by Di Trani, Justin M, Gheorghita, Andreea A, Turner, Madison, Brzezinski, Peter, Ädelroth, Pia, Vahidi, Siavash, Howell, P Lynne, Rubinstein, John L

“…Energy conversion by electron transport chains occurs through the sequential transfer of electrons between protein complexes and intermediate electron…”
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Structure of mycobacterial CIII.sub.2CIV.sub.2 respiratory supercomplex bound to the tuberculosis drug candidate telacebec by Yanofsky, David J, Di Trani, Justin M, Król, Sylwia, Abdelaziz, Rana, Bueler, Stephanie A, Imming, Peter, Brzezinski, Peter, Rubinstein, John L

“…The imidazopyridine telacebec, also known as Q203, is one of only a few new classes of compounds in more than 50 years with demonstrated antituberculosis…”
Get full text

Imidazopyridine Amides: Synthesis, Mycobacterium smegmatis CIII 2 CIV 2 Supercomplex Binding, and In Vitro Antimycobacterial Activity by Abdelaziz, Rana, Di Trani, Justin M, Sahile, Henok, Mann, Lea, Richter, Adrian, Liu, Zhongle, Bueler, Stephanie A, Cowen, Leah E, Rubinstein, John L, Imming, Peter

“…Q203 (telacebec) is an imidazopyridine amide (IPA) targeting the respiratory CIII CIV supercomplex of the mycobacterial electron transport chain (ETC). Aiming…”
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Measuring Enzyme Kinetics Using Isothermal Titration Calorimetry by Di Trani, Justin M

“…Enzymes play a central role in virtually all biological processes. Consequently, mutations that lead to alterations in enzyme activity can result in diseased…”
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