Search Results - "Di Pompo, Gemma"

Curcumin-Loaded Nanoparticles Impair the Pro-Tumor Activity of Acid-Stressed MSC in an In Vitro Model of Osteosarcoma by Di Pompo, Gemma Di, Cortini, Margherita, Palomba, Roberto, Di Francesco, Valentina Di, Bellotti, Elena, Decuzzi, Paolo, Baldini, Nicola, Avnet, Sofia

“…In the tumor microenvironment, mesenchymal stromal cells (MSCs) are key modulators of cancer cell behavior in response to several stimuli. Intratumoral…”
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Osteoclast differentiation from human blood precursors on biomimetic calcium-phosphate substrates by Ciapetti, Gabriela, Di Pompo, Gemma, Avnet, Sofia, Martini, Desirée, Diez-Escudero, Anna, Montufar, Edgar B., Ginebra, Maria-Pau, Baldini, Nicola

“…[Display omitted] The design of synthetic bone grafts to foster bone formation is a challenge in regenerative medicine. Understanding the interaction of bone…”
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Pre-clinical Models for Studying the Interaction Between Mesenchymal Stromal Cells and Cancer Cells and the Induction of Stemness by Avnet, Sofia, Lemma, Silvia, Cortini, Margherita, Di Pompo, Gemma, Perut, Francesca, Baldini, Nicola

“…Mesenchymal stromal cells (MSC) have essential functions in building and supporting the tumour microenvironment, providing metastatic niches, and maintaining…”
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Effect of calcium phosphate heparinization on the in vitro inflammatory response and osteoclastogenesis of human blood precursor cells by Diez‐Escudero, Anna, Torreggiani, Elena, Di Pompo, Gemma, Espanol, Montserrat, Persson, Cecilia, Ciapetti, Gabriela, Baldini, Nicola, Ginebra, Maria‐Pau

“…The immobilization of natural molecules on synthetic bone grafts stands as a strategy to enhance their biological interactions. During the early stages of…”
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Energy metabolism in osteoclast formation and activity by Lemma, Silvia, Sboarina, Martina, Porporato, Paolo E., Zini, Nicoletta, Sonveaux, Pierre, Di Pompo, Gemma, Baldini, Nicola, Avnet, Sofia

“…[Display omitted] Osteoclastogenesis and osteolysis are energy-consuming processes supported by high metabolic activities. In human osteoclasts derived from…”
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Cause and effect of microenvironmental acidosis on bone metastases by Avnet, Sofia, Di Pompo, Gemma, Lemma, Silvia, Baldini, Nicola

“…Skeletal involvement is a frequent and troublesome complication in advanced cancers. In the process of tumor cells homing to the skeleton to form bone…”
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3D Printing and Bioprinting to Model Bone Cancer: The Role of Materials and Nanoscale Cues in Directing Cell Behavior by Fischetti, Tiziana, Di Pompo, Gemma, Baldini, Nicola, Avnet, Sofia, Graziani, Gabriela

“…Bone cancer, both primary and metastatic, is characterized by a low survival rate. Currently, available models lack in mimicking the complexity of bone, of…”
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Acid Microenvironment in Bone Sarcomas by Di Pompo, Gemma, Cortini, Margherita, Baldini, Nicola, Avnet, Sofia

“…In bone sarcomas, extracellular proton accumulation is an intrinsic driver of malignancy. Extracellular acidosis increases stemness, invasion, angiogenesis,…”
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Potassium citrate prevents increased osteoclastogenesis resulting from acidic conditions: Implication for the treatment of postmenopausal bone loss by Granchi, Donatella, Torreggiani, Elena, Massa, Annamaria, Caudarella, Renata, Di Pompo, Gemma, Baldini, Nicola

“…The extracellular acidic milieu in bones results in activation of osteoclasts (OC) and inhibition of osteoblasts (OB) causing a net loss of calcium from the…”
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Novel Histone Deacetylase Inhibitors Induce Growth Arrest, Apoptosis, and Differentiation in Sarcoma Cancer Stem Cells by Di Pompo, Gemma, Salerno, Manuela, Rotili, Dante, Valente, Sergio, Zwergel, Clemens, Avnet, Sofia, Lattanzi, Giovanna, Baldini, Nicola, Mai, Antonello

“…Musculoskeletal sarcomas are aggressive malignancies of bone and soft tissues often affecting children and adolescents. Histone deacetylase inhibitors (HDACi)…”
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The Release of Inflammatory Mediators from Acid-Stimulated Mesenchymal Stromal Cells Favours Tumour Invasiveness and Metastasis in Osteosarcoma by Avnet, Sofia, Lemma, Silvia, Cortini, Margherita, Di Pompo, Gemma, Perut, Francesca, Lipreri, Maria Veronica, Roncuzzi, Laura, Columbaro, Marta, Errani, Costantino, Longhi, Alessandra, Zini, Nicoletta, Heymann, Dominique, Dominici, Massimo, Grisendi, Giulia, Golinelli, Giulia, Consolino, Lorena, Longo, Dario Livio, Nanni, Cristina, Righi, Alberto, Baldini, Nicola

“…Osteosarcoma is the most frequent primary malignant bone tumour with an impressive tendency to metastasise. Highly proliferative tumour cells release a…”
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Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma by Di Pompo, Gemma, Lemma, Silvia, Canti, Lorenzo, Rucci, Nadia, Ponzetti, Marco, Errani, Costantino, Donati, Davide Maria, Russell, Shonagh, Gillies, Robert, Chano, Tokuhiro, Baldini, Nicola, Avnet, Sofia

“…Cancer-induced bone pain (CIBP) is common in patients with bone metastases (BM), significantly impairing quality of life. The current treatments for CIBP are…”
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Comparative “in vitro” evaluation of the antiresorptive activity residing in four Ayurvedic medicinal plants. Hemidesmus indicus emerges for its potential in the treatment of bone loss diseases by Di Pompo, Gemma, Poli, Ferruccio, Mandrone, Manuela, Lorenzi, Beatrice, Roncuzzi, Laura, Baldini, Nicola, Granchi, Donatella

“…Four Indian plants, traditionally used in Ayurvedic medicine: Asparagus racemosus Willd., Emblica officinalis Gaertn., Hemidesmus indicus R. Br., and Rubia…”
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Behavioral Voluntary and Social Bioassays Enabling Identification of Complex and Sex-Dependent Pain-(-Related) Phenotypes in Rats with Bone Cancer by Segelcke, Daniel, Linnemann, Jan, Pradier, Bruno, Kronenberg, Daniel, Stange, Richard, Richter, S Helene, Görlich, Dennis, Baldini, Nicola, Di Pompo, Gemma, Verri, Jr, Waldiceu A, Avnet, Sofia, Pogatzki-Zahn, Esther M

“…Cancer-induced bone pain (CIBP) is a common and devastating symptom with limited treatment options in patients, significantly affecting their quality of life…”
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Radiodynamic Therapy with Acridine Orange Is an Effective Treatment for Bone Metastases by Di Pompo, Gemma, Kusuzaki, Katsuyuki, Ponzetti, Marco, Leone, Vito Ferdinando, Baldini, Nicola, Avnet, Sofia

“…Current multimodal treatment of bone metastases is partially effective and often associated with side effects, and novel therapeutic options are needed…”
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Acid-Induced Inflammatory Cytokines in Osteoblasts: A Guided Path to Osteolysis in Bone Metastasis by Di Pompo, Gemma, Errani, Costantino, Gillies, Robert, Mercatali, Laura, Ibrahim, Toni, Tamanti, Jacopo, Baldini, Nicola, Avnet, Sofia

“…Bone metastasis (BM) is a dismal complication of cancer that frequently occurs in patients with advanced carcinomas and that often manifests as an osteolytic…”
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Focus Ion Beam/Scanning Electron Microscopy Characterization of Osteoclastic Resorption of Calcium Phosphate Substrates by Diez-Escudero, Anna, Espanol, Montserrat, Montufar, Edgar B, Di Pompo, Gemma, Ciapetti, Gabriela, Baldini, Nicola, Ginebra, Maria-Pau

“…This article presents the application of dual focused ion beam/scanning electron microscopy (FIB-SEM) imaging for preclinical testing of calcium phosphates…”
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Synthesis, characterization and biological activity of hydroxyl-bisphosphonic analogs of bile acids by Bortolini, Olga, Fantin, Giancarlo, Fogagnolo, Marco, Rossetti, Stefano, Maiuolo, Loredana, Di Pompo, Gemma, Avnet, Sofia, Granchi, Donatella

“…Bisphosphonates (BPs) are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis, and tumor bone diseases…”
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Cancer‐associated mesenchymal stroma fosters the stemness of osteosarcoma cells in response to intratumoral acidosis via NF‐κB activation by Avnet, Sofia, Di Pompo, Gemma, Chano, Tokuhiro, Errani, Costantino, Ibrahim‐Hashim, Arig, Gillies, Robert J., Donati, Davide Maria, Baldini, Nicola

“…The role of mesenchymal stem cells (MSC) in osteosarcoma (OS), the most common primary tumor of bone, has not been extensively elucidated. We have recently…”
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Sarcoma treatment in the era of molecular medicine by Grünewald, Thomas GP, Alonso, Marta, Avnet, Sofia, Banito, Ana, Burdach, Stefan, Cidre‐Aranaz, Florencia, Di Pompo, Gemma, Distel, Martin, Dorado‐Garcia, Heathcliff, Garcia‐Castro, Javier, González‐González, Laura, Grigoriadis, Agamemnon E, Kasan, Merve, Koelsche, Christian, Krumbholz, Manuela, Lecanda, Fernando, Lemma, Silvia, Longo, Dario L, Madrigal‐Esquivel, Claudia, Morales‐Molina, Álvaro, Musa, Julian, Ohmura, Shunya, Ory, Benjamin, Pereira‐Silva, Miguel, Perut, Francesca, Rodriguez, Rene, Seeling, Carolin, Al Shaaili, Nada, Shaabani, Shabnam, Shiavone, Kristina, Sinha, Snehadri, Tomazou, Eleni M, Trautmann, Marcel, Vela, Maria, Versleijen‐Jonkers, Yvonne MH, Visgauss, Julia, Zalacain, Marta, Schober, Sebastian J, Lissat, Andrej, English, William R, Baldini, Nicola, Heymann, Dominique

“…Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent…”
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