Search Results - "Di Nucci, Flavia"

Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade by Khan, Zia, Hammer, Christian, Carroll, Jonathan, Di Nucci, Flavia, Acosta, Sergio Ley, Maiya, Vidya, Bhangale, Tushar, Hunkapiller, Julie, Mellman, Ira, Albert, Matthew L., McCarthy, Mark I., Chandler, G. Scott

“…Activation of systemic immune responses using PD-1 checkpoint inhibitors is an essential approach to cancer therapy. Yet, the extent of benefit relative to…”
Get full text

A phase I, randomized, ascending‐dose study to assess safety, pharmacokinetics, and activity of GDC‐8264, a RIP1 inhibitor, in healthy volunteers by Jones, Nicholas S., Kshirsagar, Smita, Mohanan, Vishnu, Ramakrishnan, Vidya, Di Nucci, Flavia, Ma, Ling, Mao, Jialin, Ding, Hao, Klabunde, Sha, Vucic, Domagoj, Pan, Lin, Lekkerkerker, Annemarie N., Chen, Yuan, Rothenberg, Michael E.

“…Abstract Receptor‐interacting protein 1 (RIP1) is a key regulator of multiple signaling pathways that mediate inflammatory responses and cell death. RIP1…”
Get full text

Polygenic risk for skin autoimmunity impacts immune checkpoint blockade in bladder cancer by Khan, Zia, Di Nucci, Flavia, Kwan, Antonia, Hammer, Christian, Mariathasan, Sanjeev, Rouilly, Vincent, Carroll, Jonathan, Fontes, Magnus, Acosta, Sergio Ley, Guardino, Ellie, Chen-Harris, Haiyin, Bhangale, Tushar, Mellman, Ira, Rosenberg, Jonathan, Powles, Thomas, Hunkapiller, Julie, Chandler, G. Scott, Albert, Matthew L.

“…PD-1 and PD-L1 act to restrict T cell responses in cancer and contribute to self-tolerance. Consistent with this role, PD-1 checkpoint inhibitors have been…”
Get full text

Safety and efficacy of atezolizumab in patients with autoimmune disease: Subgroup analysis of the SAUL study in locally advanced/metastatic urinary tract carcinoma by Loriot, Yohann, Sternberg, Cora N., Castellano, Daniel, Oosting, Sjoukje F., Dumez, Herlinde, Huddart, Robert, Vianna, Karina, Alonso Gordoa, Teresa, Skoneczna, Iwona, Fay, Andre P., Nolè, Franco, Massari, Francesco, Brasiuniene, Birute, Maroto, Pablo, Fear, Simon, Di Nucci, Flavia, de Ducla, Sabine, Choy, Ernest

“…Patients with pre-existing autoimmune disease (AID) are typically excluded from clinical trials of immune checkpoint inhibitors, and there are limited data on…”
Get full text

Cerebrovascular accidents in patients treated for choroidal neovascularization with ranibizumab in randomized controlled trials by Bressler, Neil M, Boyer, David S, Williams, David F, Butler, Steven, Francom, Steven F, Brown, Benton, Di Nucci, Flavia, Cramm, Timothy, Tuomi, Lisa L, Ianchulev, Tsontcho, Rubio, Roman G

“…To analyze cerebrovascular accidents (CVAs) pooled from large, randomized, controlled clinical trials of ranibizumab treatment for neovascular age-related…”
Get full text