Search Results - "Di Noia, Javier"

Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity by Casellas, Rafael, Basu, Uttiya, Yewdell, William T., Chaudhuri, Jayanta, Robbiani, Davide F., Di Noia, Javier M.

“…Key Points The immunoglobulin gene-modifying enzyme activation-induced cytidine deaminase (AID) promiscuously targets a defined subset of non-immunoglobulin…”
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Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair by Yu, Helen, Pak, Helen, Hammond-Martel, Ian, Ghram, Mehdi, Rodrigue, Amélie, Daou, Salima, Barbour, Haithem, Corbeil, Luc, Hébert, Josée, Drobetsky, Elliot, Masson, Jean Yves, Noia, Javier M. Di, El Bachir Affar

“…The cellular response to highly genotoxic DNA double-strand breaks (DSBs) involves the exquisite coordination of multiple signaling and repair factors. Here,…”
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RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork by Hayran, Abdul B, Liabakk, Nina B, Aas, Per A, Kusnierczyk, Anna, Vågbø, Cathrine B, Sarno, Antonio, Iveland, Tobias S, Chawla, Konika, Zahn, Astrid, Di Noia, Javier M, Slupphaug, Geir, Kavli, Bodil

“…Abstract Activation-induced cytidine deaminase (AID) interacts with replication protein A (RPA), the major ssDNA-binding protein, to promote deamination of…”
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Molecular mechanisms of antibody somatic hypermutation by Di Noia, Javier M, Neuberger, Michael S

“…Functional antibody genes are assembled by V-D-J joining and then diversified by somatic hypermutation. This hypermutation results from stepwise incorporation…”
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Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction by Couturier, Anthony M, Fleury, Hubert, Patenaude, Anne-Marie, Bentley, Victoria L, Rodrigue, Amélie, Coulombe, Yan, Niraj, Joshi, Pauty, Joris, Berman, Jason N, Dellaire, Graham, Di Noia, Javier M, Mes-Masson, Anne-Marie, Masson, Jean-Yves

“…APRIN (PDS5 cohesin associated factor B) interacts with both the cohesin complex and the BRCA2 tumor suppressor. How APRIN influences cohesion and DNA repair…”
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Unequal opportunity during class switching by Di Noia, Javier M.

“…The DNA breakage-and-repair mechanism that generates antibodies of different classes has, in theory, a 50% chance of occurring correctly. But this…”
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Unmutated but T cell dependent IgM antibodies targeting Streptococcus suis play an essential role in bacterial clearance by Dolbec, Dominic, Lehoux, Mélanie, de Beauville, Alexis Asselin, Zahn, Astrid, Di Noia, Javier Marcelo, Segura, Mariela

“…Streptococcus suis serotype 2 is an important encapsulated bacterial swine pathogen and zoonotic agent for which no effective vaccine exists. The interaction…”
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PRMT5 is essential for B cell development and germinal center dynamics by Litzler, Ludivine C., Zahn, Astrid, Meli, Alexandre P., Hébert, Steven, Patenaude, Anne-Marie, Methot, Stephen P., Sprumont, Adrien, Bois, Thérence, Kitamura, Daisuke, Costantino, Santiago, King, Irah L., Kleinman, Claudia L., Richard, Stéphane, Di Noia, Javier M.

“…Mechanisms regulating B cell development, activation, education in the germinal center (GC) and differentiation, underpin the humoral immune response. Protein…”
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Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm by Methot, Stephen P, Litzler, Ludivine C, Trajtenberg, Felipe, Zahn, Astrid, Robert, Francis, Pelletier, Jerry, Buschiazzo, Alejandro, Magor, Brad G, Di Noia, Javier M

“…Activation-induced deaminase (AID) initiates mutagenic pathways to diversify the antibody genes during immune responses. The access of AID to the nucleus is…”
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Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia by Morande, Pablo Elías, Sivina, Mariela, Uriepero, Angimar, Seija, Noé, Berca, Catalina, Fresia, Pablo, Landoni, Ana Inés, Di Noia, Javier M., Burger, Jan A., Oppezzo, Pablo

“…Activation-induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination of the immunoglobulin genes. As a trade-off for its…”
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Activation-induced cytidine deaminase expression by thymic B cells promotes T-cell tolerance and limits autoimmunity by Lombard-Vadnais, Félix, Chabot-Roy, Geneviève, Zahn, Astrid, Rodriguez Torres, Sahily, Di Noia, Javier M., Melichar, Heather J., Lesage, Sylvie

“…Elimination of self-reactive T cells in the thymus is critical to establish T-cell tolerance. A growing body of evidence suggests a role for thymic B cells in…”
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B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1 by Liang, Yue, Wang, HanChen, Seija, Noé, Lin, Yun Hsiao, Tung, Lin Tze, Di Noia, Javier M, Langlais, David, Nijnik, Anastasia

“…BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, through its…”
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A licensing step links AID to transcription elongation for mutagenesis in B cells by Methot, Stephen P., Litzler, Ludivine C., Subramani, Poorani Ganesh, Eranki, Anil K., Fifield, Heather, Patenaude, Anne-Marie, Gilmore, Julian C., Santiago, Gabriel E., Bagci, Halil, Côté, Jean-François, Larijani, Mani, Verdun, Ramiro E., Di Noia, Javier M.

“…Activation-induced deaminase (AID) mutates the immunoglobulin ( Ig ) genes to initiate somatic hypermutation (SHM) and class switch recombination (CSR) in B…”
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Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1 by Lin, Yun Hsiao, Liang, Yue, Wang, HanChen, Tung, Lin Tze, Förster, Michael, Subramani, Poorani Ganesh, Di Noia, Javier M, Clare, Simon, Langlais, David, Nijnik, Anastasia

“…BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, deubiquitination…”
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Activation-induced cytidine deaminase (AID) is necessary for the epithelial–mesenchymal transition in mammary epithelial cells by Muñoz, Denise P, Lee, Elbert L, Takayama, Sachiko, Coppé, Jean-Philippe, Heo, Seok-Jin, Boffelli, Dario, Di Noia, Javier M, Martin, David I K

“…Activation-induced cytidine deaminase (AID), which functions in antibody diversification, is also expressed in a variety of germ and somatic cells. Evidence…”
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Active nuclear import and cytoplasmic retention of activation-induced deaminase by Orthwein, Alexandre, Campo, Vanina A, Di Noia, Javier M, Hu, Yi, Kavli, Bodil, Buschiazzo, Alejandro, Patenaude, Anne-Marie

“…The enzyme activation-induced deaminase (AID) promotes antibody diversification after B-cell activation, by causing mutagenic lesions on DNA. Hence, AID's…”
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Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90 by Orthwein, Alexandre, Patenaude, Anne-Marie, Affar, El Bachir, Lamarre, Alain, Young, Jason C, Di Noia, Javier M

“…Activation-induced deaminase (AID) is the mutator enzyme that initiates somatic hypermutation and isotype switching of the antibody genes in B lymphocytes…”
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AID in Antibody Diversification: There and Back Again by Feng, Yuqing, Seija, Noé, Di Noia, Javier M., Martin, Alberto

“…Activation-Induced cytidine Deaminase (AID) initiates affinity maturation and isotype switching by deaminating deoxycytidines within immunoglobulin genes,…”
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Alternative end-joining and classical nonhomologous end-joining pathways repair different types of double-strand breaks during class-switch recombination by Cortizas, Elena M, Zahn, Astrid, Hajjar, Maurice E, Patenaude, Anne-Marie, Di Noia, Javier M, Verdun, Ramiro E

“…Classical nonhomologous end-joining (C-NHEJ) and alternative end-joining (A-EJ) are the main DNA double-strand break (DSB) repair pathways when a sister…”
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Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination by Zahn, Astrid, Eranki, Anil K., Patenaude, Anne-Marie, Methot, Stephen P., Fifield, Heather, Cortizas, Elena M., Foster, Paul, Imai, Kohsuke, Durandy, Anne, Larijani, Mani, Verdun, Ramiro E., Di Noia, Javier M.

“…Activation-induced deaminase (AID) triggers antibody class switch recombination (CSR) in B cells by initiating DNA double strand breaks that are repaired by…”
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