Search Results - "Di Modica, Martina"

Predicting the Efficacy of HER2-Targeted Therapies: A Look at the Host by Di Modica, Martina, Triulzi, Tiziana, Tagliabue, E.

“…HER2 is overexpressed in 20% of invasive breast cancers (BCs) and correlates with a more aggressive disease. Until the advent of targeted agents, HER2 was…”
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Breast cancer-secreted miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers by Di Modica, Martina, Regondi, Viola, Sandri, Marco, Iorio, Marilena V, Zanetti, Adriana, Tagliabue, Elda, Dr, Casalini, Patrizia, Triulzi, Tiziana

“…Abstract Exosomes-secreted microRNAs play an important role in metastatic spread. During this process breast cancer cells acquire the ability to transmigrate…”
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Early immune modulation by single-agent trastuzumab as a marker of trastuzumab benefit by Triulzi, Tiziana, Regondi, Viola, De Cecco, Loris, Cappelletti, Maria Rosa, Di Modica, Martina, Paolini, Biagio, Lollini, Pier Luigi, Di Cosimo, Serena, Sfondrini, Lucia, Generali, Daniele, Tagliabue, Elda

“…Background Optimising the selection of HER2-targeted regimens by identifying subsets of HER2-positive breast cancer (BC) patients who need more or less therapy…”
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The Link Between the Microbiota and HER2+ Breast Cancer: The New Challenge of Precision Medicine by Di Modica, Martina, Arlotta, Valeria, Sfondrini, Lucia, Tagliabue, Elda, Triulzi, Tiziana

“…The microbiota is emerging as a key player in cancer due to its involvement in several host physiological functions, including digestion, development of the…”
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HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy by Triulzi, Tiziana, Forte, Luca, Regondi, Viola, Di Modica, Martina, Ghirelli, Cristina, Carcangiu, Maria Luisa, Sfondrini, Lucia, Balsari, Andrea, Tagliabue, Elda

“…Through whole-transcriptome profiling of HER2+ breast carcinomas (BCs), we previously showed that those sensitive to trastuzumab are addicted to this…”
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HER2 mRNA Levels, Estrogen Receptor Activity and Susceptibility to Trastuzumab in Primary Breast Cancer by Triulzi, Tiziana, Regondi, Viola, Venturelli, Elisabetta, Gasparini, Patrizia, Ghirelli, Cristina, Groppelli, Jessica, Di Modica, Martina, Bianchi, Francesca, De Cecco, Loris, Sfondrini, Lucia, Tagliabue, Elda

“…While the results thus far demonstrate the clinical benefit of trastuzumab in breast cancer (BC), some patients do not respond to this drug. HER2 mRNA, alone…”
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The Emerging Role of the Microbiota in Breast Cancer Progression by Bernardo, Giancarla, Le Noci, Valentino, Di Modica, Martina, Montanari, Elena, Triulzi, Tiziana, Pupa, Serenella M, Tagliabue, Elda, Sommariva, Michele, Sfondrini, Lucia

“…Emerging evidence suggests a profound association between the microbiota composition in the gastrointestinal tract and breast cancer progression. The gut…”
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Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumor growth by McKee, Alastair M., Kirkup, Benjamin M., Madgwick, Matthew, Fowler, Wesley J., Price, Christopher A., Dreger, Sally A., Ansorge, Rebecca, Makin, Kate A., Caim, Shabhonam, Le Gall, Gwenaelle, Paveley, Jack, Leclaire, Charlotte, Dalby, Matthew, Alcon-Giner, Cristina, Andrusaite, Anna, Feng, Tzu-Yu, Di Modica, Martina, Triulzi, Tiziana, Tagliabue, Elda, Milling, Simon W.F., Weilbaecher, Katherine N., Rutkowski, Melanie R., Korcsmáros, Tamás, Hall, Lindsay J., Robinson, Stephen D.

“…The gut microbiota’s function in regulating health has seen it linked to disease progression in several cancers. However, there is limited research detailing…”
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Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment by Lam, Khiem C., Araya, Romina E., Huang, April, Chen, Quanyi, Di Modica, Martina, Rodrigues, Richard R., Lopès, Amélie, Johnson, Sarah B., Schwarz, Benjamin, Bohrnsen, Eric, Cogdill, Alexandria P., Bosio, Catharine M., Wargo, Jennifer A., Lee, Maxwell P., Goldszmid, Romina S.

“…The tumor microenvironment (TME) influences cancer progression and therapy response. Therefore, understanding what regulates the TME immune compartment is…”
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Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer by Di Modica, Martina, Gargari, Giorgio, Regondi, Viola, Bonizzi, Arianna, Arioli, Stefania, Belmonte, Beatrice, De Cecco, Loris, Fasano, Elena, Bianchi, Francesca, Bertolotti, Alessia, Tripodo, Claudio, Villani, Laura, Corsi, Fabio, Guglielmetti, Simone, Balsari, Andrea, Triulzi, Tiziana, Tagliabue, Elda

“…Emerging evidence indicates that gut microbiota affect the response to anticancer therapies by modulating the host immune system. In this study, we…”
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Reduction of Staphylococcus epidermidis in the mammary tumor microbiota induces antitumor immunity and decreases breast cancer aggressiveness by Bernardo, Giancarla, Le Noci, Valentino, Ottaviano, Emerenziana, De Cecco, Loris, Camisaschi, Chiara, Guglielmetti, Simone, Di Modica, Martina, Gargari, Giorgio, Bianchi, Francesca, Indino, Serena, Sartori, Patrizia, Borghi, Elisa, Sommariva, Michele, Tagliabue, Elda, Triulzi, Tiziana, Sfondrini, Lucia

“…The mammary gland hosts a microbiota, which differs between malignant versus normal tissue. We found that aerosolized antibiotics decrease murine mammary tumor…”
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Neutrophil dynamics in the tumor microenvironment determines therapy efficacy and is regulated by microbiota by Araya, Romina E, Lam, Khiem C, Huang, April, Chen, Quanyi, Di Modica, Martina, Lopes, Amelie, Yang, Howard, Liu, Huaitian, Lee, Maxwell P., Goldszmid, Romina S.

“…Abstract Neutrophils play an important role in cancer progression and both pro- and antitumorigenic functions have been described. However, their role in…”
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Abstract P4-10-32: Commensal gut microbiota influences efficacy of trastuzumab in patients with HER2-positive breast carcinoma by Tagliabue, Elda, Modica, Martina Di, Gargari, Giorgio, Regondi, Viola, Bonizzi, Arianna, Arioli, Stefania, Corsi, Fabio, Guglielmetti, Simone, Triulzi, Tiziana

“…Abstract Although the clinical benefit of trastuzumab for the management of HER2-positive breast carcinomas (BCs) has been largely demonstrated, many women,…”
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Taxanes enhance trastuzumab-mediated ADCC on tumor cells through NKG2D-mediated NK cell recognition by Di Modica, Martina, Sfondrini, Lucia, Regondi, Viola, Varchetta, Stefania, Oliviero, Barbara, Mariani, Gabriella, Bianchi, Giulia Valeria, Generali, Daniele, Balsari, Andrea, Triulzi, Tiziana, Tagliabue, Elda

“…Recent clinical data indicate a synergistic therapeutic effect between trastuzumab and taxanes in neoadjuvantly treated HER2-positive breast cancer (BC)…”
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Abstract 4959: The gut microbiota contributes to the effectiveness of HER2-targeted therapy by Modica, Martina Di, Regondi, Viola, Gargari, Giorgio, Bonizzi, Arianna, Arioli, Stefania, Belmonte, Beatrice, Tripodo, Claudio, Guglielmetti, Simone, Corsi, Fabio, Triulzi, Tiziana, Tagliabue, Elda

“…Abstract Recently, the composition of the gut microbiota, due to its influence on host immune system, has been linked to the effectiveness of chemotherapy and…”
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Abstract 748: Targeting the crosstalk between tumor cells and adipocytes to block breast cancer progression by Triulzi, Tiziana, Ciravolo, Valentina, Regondi, Viola, Di Modica, Martina, Chiodoni, Claudia, Tagliabue, Elda

“…Abstract It is now well-established that the local microenvironment of an emerging tumor plays a vital role in various steps of tumorigenesis. Stromal cells,…”
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Gut Microbiota and Trastuzumab Response in HER2-Positive Breast Cancer by Di Modica, Martina

“…The use of trastuzumab as standard treatment for HER2-positive breast carcinomas (BCs) had largely improved the clinical outcome of BCs patients…”
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Maspin influences response to doxorubicin by changing the tumor microenvironment organization by Triulzi, Tiziana, Ratti, Manuela, Tortoreto, Monica, Ghirelli, Cristina, Aiello, Piera, Regondi, Viola, Di Modica, Martina, Cominetti, Denis, Carcangiu, Maria L., Moliterni, Angela, Balsari, Andrea, Casalini, Patrizia, Tagliabue, Elda

“…Altered degradation and deposition of extracellular matrix are hallmarks of tumor progression and response to therapy. From a microarray supervised analysis on…”
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