Hypovitaminosis D: a novel finding in primary ciliary dyskinesia

A relationship between low levels of serum vitamin D and respiratory infections has been established. No study has examined the frequency and clinical relevance of vitamin D deficiency in patients with primary ciliary dyskinesia (PCD). Vitamin D levels were measured in 22 PCD patients (7 females, 10...

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Published in:	Italian journal of pediatrics Vol. 41; no. 1; p. 14
Main Authors:	Mirra, Virginia, Caffarelli, Carlo, Maglione, Marco, Valentino, Rossella, Perruolo, Giuseppe, Mazzarella, Claudia, Di Micco, Laida Lisa, Montella, Silvia, Santamaria, Francesca
Format:	Journal Article
Language:	English
Published:	England BioMed Central 22-02-2015
Subjects:	Adolescent Adult Bronchiectasis - epidemiology Child Child, Preschool Comorbidity Cross-Sectional Studies Female Humans Kartagener Syndrome - blood Kartagener Syndrome - epidemiology Kartagener Syndrome - pathology Male Motor Activity Quality of Life Vitamin D Deficiency - epidemiology Young Adult
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Summary:	A relationship between low levels of serum vitamin D and respiratory infections has been established. No study has examined the frequency and clinical relevance of vitamin D deficiency in patients with primary ciliary dyskinesia (PCD). Vitamin D levels were measured in 22 PCD patients (7 females, 10.5 years, range, 2-34 years). In PCD, pulmonary function tests (PFTs), sputum microbiology, self-reported physical activity (PA) level, and quality of life (QoL) by means of the Saint George's Respiratory Questionnaire (SGRQ), were also assessed. Seventy-two percent of PCD patients were vitamin-D deficient-to-insufficient and 28% were sufficient. No differences in PFTs parameters were found between vitamin D deficiency-to-insufficiency and sufficiency groups. Patients with vitamin D deficiency-to-insufficiency had significantly higher SGRQ total scores, and thus poorer QoL (p = 0.03). Seventy-nine percent of PCD subjects had limitations in performing vigorous activities, and 53% performed less than 3 hours of PA per week. Vitamin D deficiency-to-insufficiency and sufficiency groups did not show any differences in age at PCD diagnosis or at onset of respiratory symptoms, BMI, atopy, current asthma or bronchiectasis. However, 79% of patients with bronchiectasis had vitamin D deficiency-to-insufficiency. No differences were found in the rate of positive sputum cultures and in the number of antibiotic courses between the two groups. Hypovitaminosis D is common in PCD patients, and is associated with poorer QoL. We recommend the assessment and treatment of hypovitaminosis D to be included in the routine management of PCD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1824-7288 1824-7288
DOI:	10.1186/s13052-015-0119-5