Gender differences of at risk patients with overt heart failure in the real world of general practice. Data from the GIPSI (Gestione Integrata Progetto Scompenso in Italia) registry

Gender differences of at risk patients with overt heart failure in the real world of general practice. Data from the GIPSI (Gestione Integrata Progetto Scompenso in Italia) registry

Controlled clinical trials have defined the characteristics of specialized world populations, different from the real world population. On this basis, the GIPSI registry was created, aiming to collect data from heart failure populations managed by general practitioners, focusing on gender difference...

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Bibliographic Details
Published in:Giornale italiano di cardiologia (2006) Vol. 11; no. 3; p. 233
Main Authors: Gronda, Edoardo, Aronica, Alberto, Visconti, Marco, Di Malta, Antonio, Pini, Daniela, Mangiavacchi, Maurizio, Andreuzzi, Bruno, Municinò, Annamaria, Genovese, Stefano, Morenghi, Emanuela
Format: Journal Article
Language:Italian
Published: Italy 01-03-2010
Subjects:
Aged
Aged, 80 and over
Blood Pressure
Comorbidity
Diabetes Mellitus, Type 2 - epidemiology
Family Practice
Female
Glomerular Filtration Rate
Heart Failure - diagnostic imaging
Heart Failure - drug therapy
Heart Failure - epidemiology
Heart Failure - physiopathology
Heart Rate
Humans
Hypercholesterolemia - epidemiology
Hyperlipidemias - epidemiology
Incidence
Italy - epidemiology
Male
Middle Aged
Myocardial Ischemia - blood
Myocardial Ischemia - epidemiology
Radiography, Thoracic
Registries
Risk Factors
Sex Factors
Smoking - adverse effects
Triglycerides - blood
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Summary:Controlled clinical trials have defined the characteristics of specialized world populations, different from the real world population. On this basis, the GIPSI registry was created, aiming to collect data from heart failure populations managed by general practitioners, focusing on gender differences. The registry was based on family history, clinical and laboratory data collection from general practitioners. Patients were considered as being at risk for heart failure if data applied to stage A/B, or presenting overt heart failure if data applied to stage C/D of the American College of Cardiology/American Heart Association classification. From June 2006 to October 2007, 757 consecutive patients (475 male, 62.7%) were enrolled from 260 general practitioner's practices; 227 patients (143 male, 63.0%) had overt heart failure. In the female population at risk, higher systolic and diastolic blood pressure values were observed, whereas males showed more frequently ischemic heart disease, hypercholesterolemia and hypertriglyceridemia, and were more often prescribed with statins and antiplatelet drugs. There were more heart failure females with diabetes and of advanced age. Moreover, females showed a higher pulse pressure and a significantly lower estimated glomerular filtration rate (by simplified MDRD equation) than males. The data collected in a real world population show that heart failure has significantly different gender characteristics, especially for risk factors, age, blood pressure and renal function. This kind of investigation should be extended to larger patient populations for a better understanding of the disease.
ISSN:1827-6806