Search Results - "Di Guilmi, A M"
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Identification of a Structural Determinant for Resistance to β -lactam Antibiotics in Gram-Positive Bacteria
Published in Proceedings of the National Academy of Sciences - PNAS (10-11-1998)“…Streptococcus pneumoniae is the main causal agent of pathologies that are increasingly resistant to antibiotic treatment. Clinical resistance of S. pneumoniae…”
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2
Association of RrgA and RrgC into the Streptococcus pneumoniae Pilus by Sortases C-2 and C-3
Published in Biochemistry (Easton) (10-01-2012)“…Pili are surface-exposed virulence factors involved in the adhesion of bacteria to host cells. The human pathogen Streptococcus pneumoniae expresses a pilus…”
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3
Interaction of Penicillin‐Binding Protein 2x and Ser/Thr protein kinase StkP, two key players in Streptococcus pneumoniae R6 morphogenesis
Published in Molecular microbiology (01-10-2013)“…Summary Bacterial cell growth and division require the co‐ordinated action of peptidoglycan biosynthetic enzymes and cell morphogenesis proteins. However, the…”
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4
Autocatalytic association of proteins by covalent bond formation: a Bio Molecular Welding toolbox derived from a bacterial adhesin
Published in Scientific reports (02-03-2017)“…Unusual intramolecular cross-links present in adhesins from Gram-positive bacteria have been used to develop a generic process amenable to biotechnology…”
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5
Nascent teichoic acids insertion into the cell wall directs the localization and activity of the major pneumococcal autolysin LytA
Published in Cell surface (Amsterdam) (01-06-2018)“…[Display omitted] •Peptidoglycan which sustains bacterial growth is targeted by b-lactam antibiotics.•Spread of antibiotic resistance requires the development…”
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6
Mutations in the active site of penicillin-binding protein PBP2x from Streptococcus pneumoniae. Role in the specificity for beta-lactam antibiotics
Published in The Journal of biological chemistry (02-07-1999)“…Penicillin-binding protein 2x (PBP2x) isolated from clinical beta-lactam-resistant strains of Streptococcus pneumoniae (R-PBP2x) have a reduced affinity for…”
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7
Identification, Purification, and Characterization of Transpeptidase and Glycosyltransferase Domains of Streptococcus pneumoniae Penicillin-Binding Protein 1a
Published in Journal of Bacteriology (01-11-1998)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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8
Deacylation Kinetics Analysis of Streptococcus pneumoniae Penicillin-Binding Protein 2x Mutants Resistant to β-Lactam Antibiotics Using Electrospray Ionization– Mass Spectrometry
Published in Analytical biochemistry (10-09-2000)“…Penicillin-binding proteins (PBPs) catalyze the transpeptidase reaction involved in peptidoglycan synthesis and are covalently inhibited by the β-lactam…”
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9
Glycosyltransferase Domain of Penicillin-Binding Protein 2a from Streptococcus pneumoniae Is Membrane Associated
Published in Journal of Bacteriology (01-05-1999)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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10
Interaction of P enicillin‐ B inding P rotein 2x and Ser / Thr protein kinase StkP , two key players in S treptococcus pneumoniae R 6 morphogenesis
Published in Molecular microbiology (01-10-2013)“…Summary Bacterial cell growth and division require the co‐ordinated action of peptidoglycan biosynthetic enzymes and cell morphogenesis proteins. However, the…”
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11
Human adenovirus serotype 3 (Ad3) and the Ad3 fiber protein bind to a 130-kDa membrane protein on HeLa cells
Published in Virus research (01-09-1995)“…The fiber protein of adenovirus mediates the interaction of adenovirus with cell membrane receptors. We have produced the Ad3 fiber protein in the baculovirus…”
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12
Peptidoglycan O‐acetylation is functionally related to cell wall biosynthesis and cell division in Streptococcus pneumoniae
Published in Molecular microbiology (01-12-2017)“…Summary The peptidoglycan is a rigid matrix required to resist turgor pressure and to maintain the cellular shape. It is formed by linear glycan chains…”
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13
Molecular mechanisms of antibiotic resistance in gram-positive pathogens
Published in Current drug targets. Infectious disorders (01-05-2001)“…The widespread and uncontrolled use of antibiotics, both for human consumption and animal feed, has encouraged the development of drug resistance in a variety…”
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14
AdcAII, A New Pneumococcal Zn-Binding Protein Homologous with ABC Transporters: Biochemical and Structural Analysis
Published in Journal of molecular biology (05-09-2008)“…Regulation of metal homeostasis is vital for pathogenic bacteria facing drastic metal concentration changes in various locations within the host during…”
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15
Oligomerization of type III secretion proteins PopB and PopD precedes pore formation in Pseudomonas
Published in The EMBO journal (01-10-2003)“…Pseudomonas aeruginosa is the agent of opportunistic infections in immunocompromised individuals and chronic respiratory illnesses in cystic fibrosis patients…”
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16
Interaction of Penicillin-Binding Protein 2x and Ser/Thr protein kinase StkP, two key players in Streptococcus pneumoniaeR6 morphogenesis
Published in Molecular microbiology (01-10-2013)“…Bacterial cell growth and division require the co-ordinated action of peptidoglycan biosynthetic enzymes and cell morphogenesis proteins. However, the…”
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17
Crystal Structure of Penicillin-binding Protein 1a (PBP1a) Reveals a Mutational Hotspot Implicated in β-Lactam Resistance in Streptococcus pneumoniae
Published in Journal of molecular biology (27-01-2006)“…Streptococcus pneumoniae is a major human pathogen whose infections have been treated with β-lactam antibiotics for over 60 years, but the proliferation of…”
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18
Structure-Based Phylogeny of the Metallo-β-Lactamases
Published in Antimicrobial Agents and Chemotherapy (01-07-2005)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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19
Active Site Restructuring Regulates Ligand Recognition in Class A Penicillin-Binding Proteins
Published in Proceedings of the National Academy of Sciences - PNAS (18-01-2005)“…Bacterial cell division is a complex, multimolecular process that requires biosynthesis of new peptidoglycan by penicillin-binding proteins (PBPs) during cell…”
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20
Crystal structure of phosphorylcholine esterase domain of the virulence factor choline-binding protein e from streptococcus pneumoniae: new structural features among the metallo-beta-lactamase superfamily
Published in The Journal of biological chemistry (05-08-2005)“…Streptococcus pneumoniae is the worldwide leading cause of deaths from invasive infections such as pneumoniae, sepsis, and meningitidis in children and the…”
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