Search Results - "Di Giuseppe, Gianfranco"

Why do some glucose-lowering agents improve non-alcoholic fatty liver disease whereas others do not? A narrative review in search of a unifying hypothesis by Ciccarelli, Gea, Di Giuseppe, Gianfranco, Cinti, Francesca, Moffa, Simona, Mezza, Teresa, Giaccari, Andrea

“…Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) are metabolic disorders connected by common pathophysiological mechanisms. Since insulin…”
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Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional β cells in predicting diabetes by Mezza, Teresa, Ferraro, Pietro Manuel, Di Giuseppe, Gianfranco, Moffa, Simona, Cefalo, Chiara M.A., Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Quero, Giuseppe, Pontecorvi, Alfredo, Mari, Andrea, Alfieri, Sergio, Giaccari, Andrea

“…BACKGROUND. The appearance of hyperglycemia is due to insulin resistance, functional deficits in the secretion of insulin, and a reduction of ß cell mass…”
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Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes by Di Giuseppe, Gianfranco, Soldovieri, Laura, Ciccarelli, Gea, Ferraro, Pietro Manuel, Quero, Giuseppe, Cinti, Francesca, Capece, Umberto, Moffa, Simona, Nista, Enrico Celestino, Gasbarrini, Antonio, Mari, Andrea, Alfieri, Sergio, Tondolo, Vincenzo, Pontecorvi, Alfredo, Holst, Jens Juul, Giaccari, Andrea, Mezza, Teresa

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Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features by Capece, Umberto, Moffa, Simona, Improta, Ilaria, Di Giuseppe, Gianfranco, Nista, Enrico Celestino, Cefalo, Chiara M A, Cinti, Francesca, Pontecorvi, Alfredo, Gasbarrini, Antonio, Giaccari, Andrea, Mezza, Teresa

“…Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and…”
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Advancing Diabetes Research: A Novel Islet Isolation Method from Living Donors by Di Piazza, Eleonora, Todi, Laura, Di Giuseppe, Gianfranco, Soldovieri, Laura, Ciccarelli, Gea, Brunetti, Michela, Quero, Giuseppe, Alfieri, Sergio, Tondolo, Vincenzo, Pontecorvi, Alfredo, Gasbarrini, Antonio, Nista, Enrico Celestino, Giaccari, Andrea, Pani, Giovambattista, Mezza, Teresa

“…Pancreatic islet isolation is critical for type 2 diabetes research. Although -omics approaches have shed light on islet molecular profiles, inconsistencies…”
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Physical Activity and Type 2 Diabetes: In Search of a Personalized Approach to Improving β-Cell Function by Di Murro, Emanuela, Di Giuseppe, Gianfranco, Soldovieri, Laura, Moffa, Simona, Improta, Ilaria, Capece, Umberto, Nista, Enrico Celestino, Cinti, Francesca, Ciccarelli, Gea, Brunetti, Michela, Gasbarrini, Antonio, Pontecorvi, Alfredo, Giaccari, Andrea, Mezza, Teresa

“…Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases worldwide. Lifestyle interventions, including diet and physical activity (PA), are…”
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2295-PUB: Impaired First-Phase Insulin Secretion Predicts the Development of Hyperglycemia in a Human Model of Acute Beta-Cell Mass Reduction by MEZZA, TERESA, FERRARO, PIETRO MANUEL, GIUSEPPE, GIANFRANCO DI, ASSUNTA CEFALO, CHIARA MARIA, MOFFA, SIMONA, QUERO, GIUSEPPE, CINTI, FRANCESCA, IMPRONTA, FLAVIA, CAPECE, UMBERTO, ALFIERI, SERGIO, MARI, ANDREA, GIACCARI, ANDREA

“…β-cell functional defects temporally anticipate (and eventually cause) the subsequent development of hyperglycemia, whereas a significant reduction (∼50%) of…”
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The Interplay between Immune System and Microbiota in Diabetes by Giaccari, Andrea, Pontecorvi, Alfredo, Santoro, Antonio, Sorice, Gian Pio, Impronta, Flavia, Cinti, Francesca, Cefalo, Chiara M. A., Mezza, Teresa, Moffa, Simona, Di Giuseppe, Gianfranco

“…Diabetes is not a single and homogeneous disease, but a cluster of metabolic diseases characterized by the common feature of hyperglycemia. The pathogenesis of…”
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Lynch Syndrome and Thyroid Nodules: A Single Center Experience by Spinelli, Irene, Moffa, Simona, Fianchi, Francesca, Mezza, Teresa, Cinti, Francesca, Di Giuseppe, Gianfranco, Marmo, Clelia, Ianiro, Gianluca, Ponziani, Francesca Romana, Tortora, Annalisa, Riccioni, Maria Elena, Giaccari, Andrea, Gasbarrini, Antonio

“…Lynch syndrome (LS) is a genetic disease with increased risk of colorectal cancer and other malignancies. There are few reported cases of thyroid cancer in LS…”
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An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes by Soldovieri, Laura, Di Giuseppe, Gianfranco, Ciccarelli, Gea, Quero, Giuseppe, Cinti, Francesca, Brunetti, Michela, Nista, Enrico C., Gasbarrini, Antonio, Alfieri, Sergio, Pontecorvi, Alfredo, Giaccari, Andrea, Mezza, Teresa

“…Over the last decades, various approaches have been explored to restore sufficient β-cell mass in diabetic patients. Stem cells are certainly an attractive…”
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Effects of PCSK9 inhibition on glucose metabolism and β-cell function in humans: a pilot study by Moffa, Simona, Mezza, Teresa, Ferraro, Pietro Manuel, Di Giuseppe, Gianfranco, Cefalo, Chiara M A, Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Ciccarelli, Gea, Mari, Andrea, Pontecorvi, Alfredo, Giaccari, Andrea

“…Anti-PCSK9 monoclonal antibodies are effective in reducing LDL-C and cardiovascular events by neutralizing circulating PCSK9. PCSK9, however, is also expressed…”
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Anode-supported planar solid oxide fuel cells by plasma-enhanced metalorganic chemical vapor deposition (PE-MOCVD) and electrostatic spray deposition (ESD): Fabrication of dense thin layers of yttria-stabilized zirconia by PE-MOCVD by Giuseppe, Gianfranco Di, Selman, J. Robert

“…This paper reports a study of plasma-enhanced metalorganic chemical vapor deposition (PE-MOCVD) as a suitable technique for depositing dense, crack-free thin…”
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1795-P: Proinsulin-Insulin Pancreatic Islets In-situ Expression Mirrors Metabolic Defects Observed in Type 2 Diabetic and Glucose Intolerant Living Donors by BRUSCO, NOEMI, SEBASTIANI, GUIDO, LICATA, GIADA, GRIECO, GIUSEPPINA E., NIGI, LAURA, FIGNANI, DANIELA, MOFFA, SIMONA, SORICE, GIAN PIO, DI GIUSEPPE, GIANFRANCO, ASSUNTA CEFALO, CHIARA MARIA, MARI, ANDREA, DOTTA, FRANCESCO, GIACCARI, ANDREA, MEZZA, TERESA

“…Increased circulating levels of proinsulin (PI) and proinsulin-to-insulin ratio (PI/INS) is a well-known abnormality in type 2 diabetes (T2D). The exact…”
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The influence of insulin and incretin-based therapies on renal tubular transport by Rosati, Erica, Di Giuseppe, Gianfranco, Mezza, Teresa, Ferraro, Pietro Manuel

“…The tubular function of the kidney is very complex and is finely regulated by many factors. These include a variety of hormonal signaling pathways which are…”
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376-OR: Chronic Pancreatitis Does Not Induce Specific Alterations in Beta-Cell Function by CICCARELLI, GEA, DI GIUSEPPE, GIANFRANCO, CINTI, FRANCESCA, MARI, ANDREA, MEZZA, TERESA, GIACCARI, ANDREA

“…Chronic pancreatitis (CP) is the most frequent cause of diabetes due to pancreatic diseases, known as type 3c diabetes mellitus (T3cDM). Although the specific…”
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108-OR: Insulin Resistance Is Associated with Alterations in the Dynamics of Incretin Secretion by Di Giuseppe, Gianfranco, Soldovieri, Laura, Ciccarelli, Gea, Brunetti, Michela, Cinti, Francesca, Moffa, Simona, Holst, Jens J, Giaccari, Andrea, Mezza, Teresa

“…GIP and GLP-1 exert a fundamental role in glucose homeostasis, but it is still debated if modifications in GIP and GLP-1 secretion can affect the metabolic…”
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1619-P: Insulin Resistance Stimulates Intraislet GLP-1 Secretion from a-Cells in Diet-Induced Obese Mice by Di Giuseppe, Gianfranco, Jepsen, Sara L, Ucin, Jon Vergara, Hartmann, Bolette, Giaccari, Andrea, Holst, Jens J, Mezza, Teresa

“…It has been recently hypothesized that alpha α-cells are a potential source of intraislet GLP-1, eventually exerting paracrine effects on islet function…”
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1535-P: Type 2 Diabetes Remission after Roux-en-Y Gastric Bypass Is Related to a Reduction of Pancreatic Noradrenergic Innervation and Beta-Cell Redifferentiation by Cinti, Francesca, Avolio, Adriana, Morciano, Cassandra, Gugliandolo, Shawn, Capece, Umberto, Mezza, Teresa, Soldovieri, Laura, Ciccarelli, Gea, Di Giuseppe, Gianfranco, Moffa, Simona, Giaccari, Andrea

“…Background: β cell dedifferentiation has been identified as the process responsible for the functional "disappearance" of β cells from the islets of diabetic…”
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140-OR: The Coronary Flow Reserve Increase after Dapagliflozin Treatment in Patients with Type 2 Diabetes Is Maintained after Four Years-A Four-Year DAPAHEART Follow-up Study by Morciano, Cassandra, Cinti, Francesca, Sorice, Gian Pio, Leccisotti, Lucia, Gugliandolo, Shawn, Capece, Umberto, Cappannoli, Luigi, D'Amario, Domenico, Mezza, Teresa, Di Giuseppe, Gianfranco, Ciccarelli, Gea, Soldovieri, Laura, Giaccari, Andrea

“…Introduction & Objective: Cardiovascular (CV) outcome trials have shown that in patients with type 2 diabetes (T2D), treatment with sodium-glucose…”
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First-phase insulin secretion: can its evaluation direct therapeutic approaches? by Di Giuseppe, Gianfranco, Ciccarelli, Gea, Soldovieri, Laura, Capece, Umberto, Cefalo, Chiara M.A., Moffa, Simona, Nista, Enrico C., Brunetti, Michela, Cinti, Francesca, Gasbarrini, Antonio, Pontecorvi, Alfredo, Giaccari, Andrea, Mezza, Teresa

“…β Cells can adapt to pathological metabolic conditions by implementing plasticity mechanisms to increase their mass and enhance insulin secretion, thus…”
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