Search Results - "Di Croce, Luciano"

Engaging chromatin: PRC2 structure meets function by Chammas, Paul, Mocavini, Ivano, Di Croce, Luciano

“…Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex involved in the regulation of gene expression in metazoans. PRC2 is formed by a…”
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The Dynamic Regulatory Genome of Capsaspora and the Origin of Animal Multicellularity by Sebé-Pedrós, Arnau, Ballaré, Cecilia, Parra-Acero, Helena, Chiva, Cristina, Tena, Juan J., Sabidó, Eduard, Gómez-Skarmeta, José Luis, Di Croce, Luciano, Ruiz-Trillo, Iñaki

“…The unicellular ancestor of animals had a complex repertoire of genes linked to multicellular processes. This suggests that changes in the regulatory genome,…”
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Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells by Morey, Lluis, Pascual, Gloria, Cozzuto, Luca, Roma, Guglielmo, Wutz, Anton, Benitah, Salvador Aznar, Di Croce, Luciano

“…Polycomb group proteins are essential regulators of cell fate decisions during embryogenesis. In mammals, at least five different Cbx proteins (Cbx2, Cbx4,…”
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DNA methylation of the gonadal aromatase (cyp19a) promoter is involved in temperature-dependent sex ratio shifts in the European sea bass by Navarro-Martín, Laia, Viñas, Jordi, Ribas, Laia, Díaz, Noelia, Gutiérrez, Arantxa, Di Croce, Luciano, Piferrer, Francesc

“…Sex ratio shifts in response to temperature are common in fish and reptiles. However, the mechanism linking temperature during early development and sex ratios…”
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The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation by Kloet, Susan L, Makowski, Matthew M, Baymaz, H Irem, van Voorthuijsen, Lisa, Karemaker, Ino D, Santanach, Alexandra, Jansen, Pascal W T C, Di Croce, Luciano, Vermeulen, Michiel

“…Proteomic and genomic analysis of Polycomb group complexes in embryonic stem cells and neural progenitor cells identifies new PRC1 and PRC2 interaction…”
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Productive visualization of high-throughput sequencing data using the SeqCode open portable platform by Blanco, Enrique, González-Ramírez, Mar, Di Croce, Luciano

“…Large-scale sequencing techniques to chart genomes are entirely consolidated. Stable computational methods to perform primary tasks such as quality control,…”
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RYBP and Cbx7 Define Specific Biological Functions of Polycomb Complexes in Mouse Embryonic Stem Cells by Morey, Lluis, Aloia, Luigi, Cozzuto, Luca, Benitah, Salvador Aznar, Di Croce, Luciano

“…The Polycomb repressive complex 1 (PRC1) is required for decisions of stem cell fate. In mouse embryonic stem cells (ESCs), two major variations of PRC1…”
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Regulation of Human Epidermal Stem Cell Proliferation and Senescence Requires Polycomb- Dependent and -Independent Functions of Cbx4 by Luis, Nuno Miguel, Morey, Lluis, Mejetta, Stefania, Pascual, Gloria, Janich, Peggy, Kuebler, Bernd, Roma, Guglielmo, Nascimento, Elisabete, Frye, Michaela, Di Croce, Luciano, Benitah, Salvador Aznar

“…Human epidermal stem cells transit from a slow cycling to an actively proliferating state to contribute to homeostasis. Both stem cell states differ in their…”
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Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination by Lee, Min Gyu, Villa, Raffaella, Trojer, Patrick, Norman, Jessica, Yan, Kai-Ping, Reinberg, Danny, Croce, Luciano Di, Shiekhattar, Ramin

“…Methylation of histone H3 lysine 27 (H3K27) is a posttranslational modification that is highly correlated with genomic silencing. Here we show that human UTX,…”
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miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate by Ji, Yun, Fioravanti, Jessica, Zhu, Wei, Wang, Hongjun, Wu, Tuoqi, Hu, Jinhui, Lacey, Neal E., Gautam, Sanjivan, Le Gall, John B., Yang, Xia, Hocker, James D., Escobar, Thelma M., He, Shan, Dell’Orso, Stefania, Hawk, Nga V., Kapoor, Veena, Telford, William G., Di Croce, Luciano, Muljo, Stefan A., Zhang, Yi, Sartorelli, Vittorio, Gattinoni, Luca

“…T cell senescence and exhaustion are major barriers to successful cancer immunotherapy. Here we show that miR-155 increases CD8 + T cell antitumor function by…”
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Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures by García-Pérez, Raquel, Esteller-Cucala, Paula, Mas, Glòria, Lobón, Irene, Di Carlo, Valerio, Riera, Meritxell, Kuhlwilm, Martin, Navarro, Arcadi, Blancher, Antoine, Di Croce, Luciano, Gómez-Skarmeta, José Luis, Juan, David, Marquès-Bonet, Tomàs

“…Changes in the epigenetic regulation of gene expression have a central role in evolution. Here, we extensively profiled a panel of human, chimpanzee, gorilla,…”
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PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells by Jain, Payal, Ballare, Cecilia, Blanco, Enrique, Vizan, Pedro, Di Croce, Luciano

“…The Polycomb-like protein PHF19/PCL3 associates with PRC2 and mediates its recruitment to chromatin in embryonic stem cells. PHF19 is also overexpressed in…”
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SpikChIP: a novel computational methodology to compare multiple ChIP-seq using spike-in chromatin by Blanco, Enrique, Di Croce, Luciano, Aranda, Sergi

“…Abstract In order to evaluate cell- and disease-specific changes in the interacting strength of chromatin targets, ChIP-seq signal across multiple conditions…”
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Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer by Rondinelli, Beatrice, Rosano, Dalia, Antonini, Elena, Frenquelli, Michela, Montanini, Laura, Huang, DaChuan, Segalla, Simona, Yoshihara, Kosuke, Amin, Samir B, Lazarevic, Dejan, The, Bin Tean, Verhaak, Roel G W, Futreal, P Andrew, Di Croce, Luciano, Chin, Lynda, Cittaro, Davide, Tonon, Giovanni

“…Mutations in genes encoding chromatin-remodeling proteins are often identified in a variety of cancers. For example, the histone demethylase JARID1C is…”
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PLK1 Signaling in Breast Cancer Cells Cooperates with Estrogen Receptor-Dependent Gene Transcription by Wierer, Michael, Verde, Gaetano, Pisano, Paola, Molina, Henrik, Font-Mateu, Jofre, Di Croce, Luciano, Beato, Miguel

“…Polo-like kinase 1 (PLK1) is a key regulator of cell division and is overexpressed in many types of human cancers. Compared to its well-characterized role in…”
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Chromatin capture links the metabolic enzyme AHCY to stem cell proliferation by Aranda, Sergi, Alcaine-Colet, Anna, Blanco, Enrique, Borràs, Eva, Caillot, Claire, Sabidó, Eduard, Di Croce, Luciano

“…Profiling the chromatin-bound proteome (chromatome) in a simple, direct, and reliable manner might be key to uncovering the role of yet uncharacterized…”
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Genome Regulation by Polycomb and Trithorax: 70 Years and Counting by Schuettengruber, Bernd, Bourbon, Henri-Marc, Di Croce, Luciano, Cavalli, Giacomo

“…Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic…”
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Polycomb complexes in stem cells and embryonic development by Aloia, Luigi, Di Stefano, Bruno, Di Croce, Luciano

“…Polycomb group (PcG) proteins are epigenetic modifiers involved in controlling gene repression. Organized within multiprotein complexes, they regulate…”
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Chromatin modifying activity of leukaemia associated fusion proteins by Di Croce, Luciano

“…The leukaemias, which are divided into chronic and acute forms, are malignant diseases of haematopoietic cells in which the proper balance between…”
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RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis by Sánchez-Molina, Sara, Figuerola-Bou, Elisabet, Blanco, Enrique, Sánchez-Jiménez, María, Táboas, Pablo, Gómez, Soledad, Ballaré, Cecilia, García-Domínguez, Daniel J, Prada, Estela, Hontecillas-Prieto, Lourdes, M Carcaboso, Ángel, Tirado, Óscar M, Hernández-Muñoz, Inmaculada, de Álava, Enrique, Lavarino, Cinzia, Di Croce, Luciano, Mora, Jaume

“…Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal translocation, EWSR1-FLI1 being the most…”
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