Search Results - "Di Castro, Silvio"

Challenges and opportunities of next generation therapeutics: A compound management perspective by Di Castro, Silvio, Svensson, Martin L.

“…In recent years, pharmaceutical research has increased its interest in novel drug modalities beyond small molecules to overcome therapeutic limitations and…”
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Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing by Wimberger, Sandra, Akrap, Nina, Firth, Mike, Brengdahl, Johan, Engberg, Susanna, Schwinn, Marie K., Slater, Michael R., Lundin, Anders, Hsieh, Pei-Pei, Li, Songyuan, Cerboni, Silvia, Sumner, Jonathan, Bestas, Burcu, Schiffthaler, Bastian, Magnusson, Björn, Di Castro, Silvio, Iyer, Preeti, Bohlooly-Y, Mohammad, Machleidt, Thomas, Rees, Steve, Engkvist, Ola, Norris, Tyrell, Cadogan, Elaine B., Forment, Josep V., Šviković, Saša, Akcakaya, Pinar, Taheri-Ghahfarokhi, Amir, Maresca, Marcello

“…Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid…”
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Closing the Design–Make–Test–Analyze Loop: Interplay between Experiments and Predictions Drives PROTACs Bioavailability by Santisteban Valencia, Zulma, Kingston, Jennifer, Miljković, Filip, Rowbottom, Hannah, Mann, Nadia, Davies, Sophie, Ekblad, Martin, Di Castro, Silvio, Kwapień, Karolina, Malmerberg, Erik, Friis, Stig D., Lundbäck, Thomas, Leek, Tomas, Wernevik, Johan

“…The drug development landscape is expanding to include drug modalities such as PROteolysis-TArgeting Chimeras (PROTACs) and peptides, offering possibilities…”
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Letter to the Editor : Implementation of Acoustic Dispensing and 384-Well Based Workflows to Improve Assay Capacity and Reduce Compound and Solvent Use in Early Drug Metabolism and Pharmacokinetics Profiling by Wernevik, Johan, Hulthe, Johan, McPheat, Cameron, Di Castro, Silvio, Lundbäck, Thomas

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