Search Results - "Di Cagno, Massimiliano Pio"

Interpreting permeability as a function of free drug fraction: The case studies of cyclodextrins and liposomes by Tzanova, Martina M., Nguyen, Lisa, Moretti, Federica, Grassi, Mario, Magnano, Greta Camilla, Voinovich, Dario, Stein, Paul C., Hiorth, Marianne, di Cagno, Massimiliano Pio

“…In order to solubilize poorly soluble active pharmaceutical ingredients, various strategies have been implemented over the years, including the use of…”
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Human Lactobacillus Biosurfactants as Natural Excipients for Nasal Drug Delivery of Hydrocortisone by Corazza, Elisa, Abruzzo, Angela, Giordani, Barbara, Cerchiara, Teresa, Bigucci, Federica, Vitali, Beatrice, di Cagno, Massimiliano Pio, Luppi, Barbara

“…The inclusion of a chemical permeation enhancer in a dosage form is considered an effective approach to improve absorption across the nasal mucosa. Herein we…”
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The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview by di Cagno, Massimiliano Pio

“…Cyclodextrins (CDs) are cyclic oligosaccharides of natural origin that were discovered more than 100 years ago. The peculiar cone-like conformation of the…”
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Drug delivery to the brain: In situ gelling formulation enhances carbamazepine diffusion through nasal mucosa models with mucin by Corazza, Elisa, di Cagno, Massimiliano Pio, Bauer-Brandl, Annette, Abruzzo, Angela, Cerchiara, Teresa, Bigucci, Federica, Luppi, Barbara

“…The objective of this work was to optimize a thermosensitive in situ gelling formulation to improve intranasal and nose-to-brain delivery of the antiepileptic…”
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Studying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopy by di Cagno, Massimiliano Pio, Stein, Paul C.

“…[Display omitted] An experimental/computational approach has been successfully applied in order to study the effect of solubilizing vehicles (cyclodextrins and…”
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Experimental Determination of Drug Diffusion Coefficients in Unstirred Aqueous Environments by Temporally Resolved Concentration Measurements by di Cagno, Massimiliano Pio, Clarelli, Fabrizio, Våbenø, Jon, Lesley, Christina, Rahman, Sokar Darsim, Cauzzo, Jennifer, Franceschinis, Erica, Realdon, Nicola, Stein, Paul C

“…The diffusion coefficient (also known as diffusivity) of an active pharmaceutical ingredient (API) is a fundamental physicochemical parameter that affects…”
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Commercially Available Cell-Free Permeability Tests for Industrial Drug Development: Increased Sustainability through Reduction of In Vivo Studies by Jacobsen, Ann-Christin, Visentin, Sonja, Butnarasu, Cosmin, Stein, Paul C, di Cagno, Massimiliano Pio

“…Replacing in vivo with in vitro studies can increase sustainability in the development of medicines. This principle has already been applied in the biowaiver…”
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Impact of Mucin on Drug Diffusion: Development of a Straightforward in Vitro Method for the Determination of Drug Diffusivity in the Presence of Mucin by Falavigna, Margherita, Stein, Paul C, Flaten, Gøril Eide, di Cagno, Massimiliano Pio

“…Mucosal drug delivery accounts for various administration routes (i.e., oral, vaginal, ocular, pulmonary, etc.) and offers a vast surface for the permeation of…”
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Influence of Lactobacillus Biosurfactants on Skin Permeation of Hydrocortisone by Abruzzo, Angela, Parolin, Carola, Corazza, Elisa, Giordani, Barbara, di Cagno, Massimiliano Pio, Cerchiara, Teresa, Bigucci, Federica, Vitali, Beatrice, Luppi, Barbara

“…One of the most widely used strategies to improve drug diffusion through the skin is the use of permeation enhancers. The aim of this work was to investigate…”
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Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract by Sallustio, Valentina, Farruggia, Giovanna, di Cagno, Massimiliano Pio, Tzanova, Martina M, Marto, Joana, Ribeiro, Helena, Goncalves, Lidia Maria, Mandrone, Manuela, Chiocchio, Ilaria, Cerchiara, Teresa, Abruzzo, Angela, Bigucci, Federica, Luppi, Barbara

“…Rising environmental awareness drives green consumers to purchase sustainable cosmetics based on natural bioactive compounds. The aim of this study was to…”
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Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes by Wu, Iren Yeeling, Bala, Sonali, Škalko-Basnet, Nataša, di Cagno, Massimiliano Pio

“…The aim of this work was to clarify the dynamics behind the influence of ionic strength on the changes in drug release from large unilamellar vesicles (LUVs)…”
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Studying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopy by Di Cagno, Massimiliano Pio, Stein, Paul C

“…An experimental/computational approach has been successfully applied in order to study the effect of solubilizing vehicles (cyclodextrins and liposomes) on the…”
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Towards a better mechanistic comprehension of drug permeation and absorption: Introducing the diffusion-partitioning interplay by Tzanova, Martina M., Randelov, Elizabeta, Stein, Paul C., Hiorth, Marianne, di Cagno, Massimiliano Pio

“…[Display omitted] •UWL represents an additional barrier to permeation in in vitro experiments.•Contribution from UWL can be quantified with the help of…”
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Validation and testing of a new artificial biomimetic barrier for estimation of transdermal drug absorption by Magnano, Greta Camilla, Sut, Stefania, Dall'Acqua, Stefano, Di Cagno, Massimiliano Pio, Lee, Luke, Lee, Ming, Larese Filon, Francesca, Perissutti, Beatrice, Hasa, Dritan, Voinovich, Dario

“…[Display omitted] Human skin remains the most reliable model for studying the transdermal permeation of active compounds. Due to the limited source, porcine…”
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Modelling drug diffusion through unstirred water layers allows real-time quantification of free/loaded drug fractions and release kinetics from colloidal-based formulations by Tzanova, Martina Martin, Moretti, Federica, Grassi, Gabriele, Stein, Paul, Hiorth, Marianne, Abrami, Michela, Grassi, Mario, Di Cagno, Massimiliano Pio

“…The correlation between in vivo and in vitro data is yet not sufficiently optimized to allow a significant reduction and replacement of animal testing in…”
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Shifting the Focus from Dissolution to Permeation: Introducing the Meso-fluidic Chip for Permeability Assessment (MCPA) by Tzanova, Martina M, Larsen, Bjarke Strøm, Birolo, Rebecca, Cignolini, Sara, Tho, Ingunn, Chierotti, Michele R, Perissutti, Beatrice, Scaglione, Silvia, Stein, Paul C, Hiorth, Marianne, Di Cagno, Massimiliano Pio

“…In response to the growing ethical and environmental concerns associated with animal testing, numerous in vitro tools of varying complexity and biorelevance…”
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Modelling drug diffusion through unstirred water layers allows real-time quantification of free/loaded drug fractions and release kinetics from colloidal-based formulations by Tzanova, Martina M., Moretti, Federica, Grassi, Gabriele, Stein, Paul C., Hiorth, Marianne, Abrami, Michela, Grassi, Mario, di Cagno, Massimiliano Pio

“…[Display omitted] The correlation between in vivo and in vitro data is yet not sufficiently optimized to allow a significant reduction and replacement of…”
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Lactobacilli cell-free supernatants: Potential green and natural enhancers for nose-to-brain delivery of small hydrophilic molecules by Corazza, Elisa, Martin, Janik, Giordani, Barbara, Vitali, Beatrice, Rossi, Martina, Abruzzo, Angela, Bigucci, Federica, Cerchiara, Teresa, di Cagno, Massimiliano Pio, Luppi, Barbara, Schindowski, Katharina

“…Concerns about environmental health are driving pharmaceutical industries towards more eco-friendly and biocompatible products. Lactobacilli cell-free…”
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Influence of the environmental tonicity perturbations on the release of model compounds from large unilamellar vesicles (LUVs): A mechanistic investigation by Wu, Iren Yeeling, Škalko-Basnet, Nataša, di Cagno, Massimiliano Pio

“…Schematic representation of the diffusion process of hydrophilic (yellow dots) and lipophilic (violet triangles) molecules across phospholipid membranes under…”
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Interpreting non-linear drug diffusion data: Utilizing Korsmeyer-Peppas model to study drug release from liposomes by Wu, Iren Yeeling, Bala, Sonali, Skalko-Basnet, Natasa, Di Cagno, Massimiliano Pio

“…The aim of this work was to clarify the dynamics behind the influence of ionic strength on the changes in drug release from large unilamellar vesicles (LUVs)…”
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