Search Results - "Di Bari, Michele"
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Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway
Published in Emerging infectious diseases (01-12-2018)“…Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in…”
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Cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation
Published in PLoS pathogens (15-04-2020)“…Prion diseases are caused by the misfolding of a host-encoded glycoprotein, PrPC, into a pathogenic conformer, PrPSc. Infectious prions can exist as different…”
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Sensitive protein misfolding cyclic amplification of sporadic Creutzfeldt–Jakob disease prions is strongly seed and substrate dependent
Published in Scientific reports (18-02-2021)“…Unlike variant Creutzfeldt–Jakob disease prions, sporadic Creutzfeldt–Jakob disease prions have been shown to be difficult to amplify in vitro by protein…”
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Full restoration of specific infectivity and strain properties from pure mammalian prion protein
Published in PLoS pathogens (01-03-2019)“…The protein-only hypothesis predicts that infectious mammalian prions are composed solely of PrPSc, a misfolded conformer of the normal prion protein, PrPC…”
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Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains
Published in Scientific reports (08-01-2020)“…Bovine Spongiform Encephalopathy (BSE) is the only animal prion which has been recognized as a zoonotic agent so far. The identification of BSE in two goats…”
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Prion Disease in Dromedary Camels, Algeria
Published in Emerging infectious diseases (01-06-2018)“…Prions cause fatal and transmissible neurodegenerative diseases, including Creutzfeldt-Jakob disease in humans, scrapie in small ruminants, and bovine…”
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Efficient transmission and characterization of Creutzfeldt-Jakob disease strains in bank voles
Published in PLoS pathogens (01-02-2006)“…Transmission of prions between species is limited by the "species barrier," which hampers a full characterization of human prion strains in the mouse model. We…”
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A single amino acid residue in bank vole prion protein drives permissiveness to Nor98/atypical scrapie and the emergence of multiple strain variants
Published in PLoS pathogens (01-06-2022)“…Prions are infectious agents that replicate through the autocatalytic misfolding of the cellular prion protein (PrP C ) into infectious aggregates (PrP Sc )…”
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Gerstmann-Sträussler-Scheinker disease subtypes efficiently transmit in bank voles as genuine prion diseases
Published in Scientific reports (04-02-2016)“…Gerstmann-Sträussler-Scheinker disease (GSS) is an inherited neurodegenerative disorder associated with mutations in the prion protein gene and accumulation of…”
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Cofactors influence the biological properties of infectious recombinant prions
Published in Acta neuropathologica (01-02-2018)“…Prion diseases are caused by a misfolding of the cellular prion protein (PrP) to a pathogenic isoform named PrP Sc . Prions exist as strains, which are…”
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Prion disease tempo determined by host-dependent substrate reduction
Published in The Journal of clinical investigation (01-02-2014)“…The symptoms of prion infection can take years or decades to manifest following the initial exposure. Molecular markers of prion disease include accumulation…”
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Stability of BSE infectivity towards heat treatment even after proteolytic removal of prion protein
Published in Veterinary research (Paris) (16-04-2021)“…The unconventional infectious agents of transmissible spongiform encephalopathies (TSEs) are prions. Their infectivity co-appears with PrP , aberrant…”
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Identification of an allelic variant of the goat PrP gene associated with resistance to scrapie
Published in Journal of general virology (01-05-2006)“…1 Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy 2 Istituto Zooprofilattico…”
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14
A tetracationic porphyrin with dual anti-prion activity
Published in iScience (15-09-2023)“…Prions are deadly infectious agents made of PrPSc, a misfolded variant of the cellular prion protein (PrPC) which self-propagates by inducing misfolding of…”
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Correlation between infectivity and disease associated prion protein in the nervous system and selected edible tissues of naturally affected scrapie sheep
Published in PloS one (25-03-2015)“…The transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of a…”
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Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America
Published in Proceedings of the National Academy of Sciences - PNAS (08-12-2020)“…Chronic wasting disease (CWD) is a relentless epidemic disorder caused by infectious prions that threatens the survival of cervid populations and raises…”
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Accumulation and aberrant composition of cholesteryl esters in Scrapie-infected N2a cells and C57BL/6 mouse brains
Published in Lipids in health and disease (04-08-2011)“…Cholesterol changes have been described in prion-cell models and in experimental rodent scrapie; yet, the pattern of this association is still controversial…”
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Molecular discrimination of sheep bovine spongiform encephalopathy from scrapie
Published in Emerging infectious diseases (01-04-2011)“…Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We…”
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Transmissibility of Gerstmann-Sträussler-Scheinker syndrome in rodent models: New insights into the molecular underpinnings of prion infectivity
Published in Prion (01-11-2016)“…Prion diseases, or transmissible spongiform encephalopathies, have revealed the bewildering phenomenon of transmissibility in neurodegenerative diseases…”
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Biochemical characterization of prion strains in bank voles
Published in Pathogens (Basel) (02-07-2013)“…Prions exist as different strains exhibiting distinct disease phenotypes. Currently, the identification of prion strains is still based on biological strain…”
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