Search Results - "Di Nardo, Giovanna"

Optimization of the bacterial cytochrome P450 BM3 system for the production of human drug metabolites by Di Nardo, Giovanna, Gilardi, Gianfranco

“…Drug metabolism in human liver is a process involving many different enzymes. Among them, a number of cytochromes P450 isoforms catalyze the oxidation of most…”
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Natural Compounds as Pharmaceuticals: The Key Role of Cytochromes P450 Reactivity by Di Nardo, Giovanna, Gilardi, Gianfranco

“…The design of drugs from natural products is a re-emerging area due to the need for bioactive compounds. The exploitation of natural products and their…”
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Self-Sufficient Class VII Cytochromes P450: From Full-Length Structure to Synthetic Biology Applications by Correddu, Danilo, Di Nardo, Giovanna, Gilardi, Gianfranco

“…Members of class VII cytochromes P450 are catalytically self-sufficient enzymes containing a phthalate dioxygenase reductase-like domain fused to the P450…”
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CYP116B5hd, a self-sufficient P450 cytochrome: A dataset of its electronic and geometrical properties by Famulari, Antonino, Correddu, Danilo, Nardo, Giovanna Di, Gilardi, Gianfranco, Chiesa, Mario, García-Rubio, Inés

“…This paper documents the dataset obtained from the Electron Paramagnetic Resonance (EPR) study of the electronic properties of a self-sufficient cytochrome…”
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Identification of Mutant Asp251Gly/Gln307His of Cytochrome P450 BM3 for the Generation of Metabolites of Diclofenac, Ibuprofen and Tolbutamide by Tsotsou, Georgia E., Sideri, Anastasia, Goyal, Abhineet, Di Nardo, Giovanna, Gilardi, Gianfranco

“…The soluble, catalytically self‐sufficient cytochrome P450 BM3 from Bacillus megaterium is a good candidate as biocatalyst for the synthesis of drug…”
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Modulating the coupling efficiency of human cytochrome P450 CYP3A4 at electrode surfaces through protein engineering by Dodhia, Vikash R., Sassone, Carlo, Fantuzzi, Andrea, Nardo, Giovanna Di, Sadeghi, Sheila J., Gilardi, Gianfranco

“…This study shows that regulating the electron flow to the heme of human cytochrome P450 CYP3A4, using artificial redox chains, can significantly enhance its…”
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Depicting the proton relay network in human aromatase: New insights into the role of the alcohol‐acid pair by Zhang, Chao, Gilardi, Gianfranco, Di Nardo, Giovanna

“…Human aromatase is the cytochrome P450 catalyzing the conversion of androgens into estrogens in a three steps reaction essential to maintain steroid hormones…”
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Design of a H2O2‐generating P450SPα fusion protein for high yield fatty acid conversion by Giuriato, Daniele, Correddu, Danilo, Catucci, Gianluca, Di Nardo, Giovanna, Bolchi, Cristiano, Pallavicini, Marco, Gilardi, Gianfranco

“…Sphingomonas paucimobilis' P450SPα (CYP152B1) is a good candidate as industrial biocatalyst. This enzyme is able to use hydrogen peroxide as unique cofactor to…”
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Multi‐Enzymatic Cascade Reactions for the Synthesis of cis,cis‐Muconic Acid by Vignali, Elisa, Pollegioni, Loredano, Di Nardo, Giovanna, Valetti, Francesca, Gazzola, Silvia, Gilardi, Gianfranco, Rosini, Elena

“…Lignin valorization allows the generation of a number of value‐added products such as cis,cis‐muconic acid (ccMA), which is widely used for the synthesis of…”
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Human cytomegalovirus US21 protein is a viroporin that modulates calcium homeostasis and protects cells against apoptosis by Luganini, Anna, Di Nardo, Giovanna, Munaron, Luca, Gilardi, Gianfranco, Pla, Alessandra Fiorio, Gribaudo, Giorgio

“…The human cytomegalovirus (HCMV) US12 gene family comprises a set of 10 contiguous genes (US12 to US21) with emerging roles in the regulation of virus cell…”
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Engineered human CYP2C9 and its main polymorphic variants for bioelectrochemical measurements of catalytic response by Panicco, Paola, Castrignanò, Silvia, Sadeghi, Sheila J., Nardo, Giovanna Di, Gilardi, Gianfranco

“…[Display omitted] •CYP2C9 and CYP2C9*2 CYP2C9*3 allelic variants are electrochemically characterised.•Enzymes were engineered linking P450 gene to flavodoxin…”
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Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor by Zhang, Chao, Schilirò, Tiziana, Gea, Marta, Bianchi, Silvia, Spinello, Angelo, Magistrato, Alessandra, Gilardi, Gianfranco, Di Nardo, Giovanna

“…The intensive use of pesticides has led to their increasing presence in water, soil, and agricultural products. Mounting evidence indicates that some…”
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Molecular and Structural Evolution of Cytochrome P450 Aromatase by Di Nardo, Giovanna, Zhang, Chao, Marcelli, Anna Giulia, Gilardi, Gianfranco

“…Aromatase is the cytochrome P450 enzyme converting androgens into estrogen in the last phase of steroidogenesis. As estrogens are crucial in reproductive…”
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Assessment of Five Pesticides as Endocrine-Disrupting Chemicals: Effects on Estrogen Receptors and Aromatase by Gea, Marta, Zhang, Chao, Tota, Roberta, Gilardi, Gianfranco, Di Nardo, Giovanna, Schilirò, Tiziana

“…Pesticides are widely applied all over the world, and pesticide exposure can induce different biological effects posing a possible threat to human health. Due…”
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Molecular Lego of Human Cytochrome P450: The Key Role of Heme Domain Flexibility for the Activity of the Chimeric Proteins by Catucci, Gianluca, Ciaramella, Alberto, Di Nardo, Giovanna, Zhang, Chao, Castrignanò, Silvia, Gilardi, Gianfranco

“…The cytochrome P450 superfamily are heme-thiolate enzymes able to carry out monooxygenase reactions. Several studies have demonstrated the feasibility of using…”
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Ultrasound–Driven Deposition of Au and Ag Nanoparticles on Citrus Pectin: Preparation and Characterisation of Antimicrobial Composites by Bucciol, Fabio, Manzoli, Maela, Zhang, Chao, Di Nardo, Giovanna, Gilardi, Gianfranco, Calcio Gaudino, Emanuela, Cravotto, Giancarlo

“…Pectin is a renewable, non–toxic and biodegradable polymer made of galacturonic acid units. Its polar groups make it suitable for complexing and supporting…”
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Heme Spin Distribution in the Substrate-Free and Inhibited Novel CYP116B5hd: A Multifrequency Hyperfine Sublevel Correlation (HYSCORE) Study by Famulari, Antonino, Correddu, Danilo, Di Nardo, Giovanna, Gilardi, Gianfranco, Mitrikas, George, Chiesa, Mario, García-Rubio, Inés

“…The cytochrome P450 family consists of ubiquitous monooxygenases with the potential to perform a wide variety of catalytic applications. Among the members of…”
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Posttranslational Modification of Human Cytochrome CYP4F11 by 4-Hydroxynonenal Impairs ω-Hydroxylation in Malaria Pigment Hemozoin-Fed Monocytes: The Role in Malaria Immunosuppression by Skorokhod, Oleksii, Triglione, Vincenzo, Barrera, Valentina, Di Nardo, Giovanna, Valente, Elena, Ulliers, Daniela, Schwarzer, Evelin, Gilardi, Gianfranco

“…Malaria is a frequent parasitic infection becomes life threatening due to the disequilibrated immune responses of the host. Avid phagocytosis of malarial…”
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Enhanced and specific epoxidation activity of P450 BM3 mutants for the production of high value terpene derivatives by Correddu, Danilo, Helmy Aly, Sabrina, Di Nardo, Giovanna, Catucci, Gianluca, Prandi, Cristina, Blangetti, Marco, Bellomo, Chiara, Bonometti, Elisabetta, Viscardi, Guido, Gilardi, Gianfranco

“…Terpenes are natural molecules of valuable interest for different industrial applications. Cytochromes P450 enzymes can functionalize terpenoids to form high…”
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Chimeric cytochrome P450 3A4 used for in vitro prediction of food–drug interactions by Sadeghi, Sheila J., Di Nardo, Giovanna, Gilardi, Gianfranco

“…Inhibition of cytochrome P450 (CYP)‐mediated drug metabolism by dietary substances is the main cause of drug–food interactions in humans. The present study…”
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