Search Results - "Di Maso, Michael J."

Design of a Kilogram Scale, Plug Flow Photoreactor Enabled by High Power LEDs by Lévesque, François, Di Maso, Michael J, Narsimhan, Karthik, Wismer, Michael K, Naber, John R

“…A simple and inexpensive photoreactor with a throughput of kilograms of material per day has been developed. This achievement was enabled by using high-power…”
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Diastereoselective Synthesis of and Mechanistic Understanding for the Formation of 2-Piperidinones from Imines and Cyano-Substituted Anhydrides by Di Maso, Michael J., Snyder, Kevin M., De Souza Fernandes, Fábio, Pattawong, Ommidala, Tan, Darlene Q., Fettinger, James C., Cheong, Paul Ha-Yeon, Shaw, Jared T.

“…2‐Piperidinones are synthesized in a single step from imines and 2‐cyano glutaric anhydrides. The reaction provides the products in good diastereoselectivity…”
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Synthesis of (±)-Bisavenanthramide B‑6 by an Anionic Anhydride Mannich Reaction by Di Maso, Michael J, Nepomuceno, Gabriella M, St. Peter, Michael A, Gitre, Haley H, Martin, Kevin S, Shaw, Jared T

“…Bisavenanthramide B-6 (2) is a highly substituted γ-lactam derived from oat leaves. Development of a new base-promoted anhydride Mannich reaction with…”
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Synthesis of 6,6′-Binaphthopyran-2-one Natural Products: Pigmentosin A, Talaroderxines A and B by Grove, Charles I, Di Maso, Michael J, Jaipuri, Firoz A, Kim, Michelle B, Shaw, Jared T

“…Efficient and stereoselective syntheses of pigmentosin A, talaroderxine A, and its diastereomer talaroderxine B are reported. The binaphthyl ring system is…”
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Enantioselective Intramolecular C–H Insertion Reactions of Donor–Donor Metal Carbenoids by Soldi, Cristian, Lamb, Kellan N, Squitieri, Richard A, González-López, Marcos, Di Maso, Michael J, Shaw, Jared T

“…The first asymmetric insertion reactions of donor–donor carbenoids, i.e., those with no pendant electron-withdrawing groups, are reported. This process enables…”
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Desymmetrization of Cyclic Sulfonimidamides by Asymmetric Allylation by Gutierrez, David A., Toth‐Williams, Garrett, Laconsay, Croix J., Yasuda, Michael, Fettinger, James C., Di Maso, Michael J., Shaw, Jared T.

“…Herein we report the first transition metal‐catalyzed approach to the enantioenriched synthesis of cyclic sulfonimidamides relying on commercially available…”
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Mechanistic Investigation of Castagnoli–Cushman Multicomponent Reactions Leading to a Three-Component Synthesis of Dihydroisoquinolones by Howard, Sara Y, Di Maso, Michael J, Shimabukuro, Kristin, Burlow, Noah P, Tan, Darlene Q, Fettinger, James C, Malig, Thomas C, Hein, Jason E, Shaw, Jared T

“…The mechanisms for the three- and four-component variants of the Castagnoli–Cushman reaction (CCR) have been investigated. A series of crossover experiments…”
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Dynamic sampling in autonomous process optimization by Christensen, Melodie, Xu, Yuting, Kwan, Eugene E, Di Maso, Michael J, Ji, Yining, Reibarkh, Mikhail, Sun, Alexandra C, Liaw, Andy, Fier, Patrick S, Grosser, Shane, Hein, Jason E

“…Autonomous process optimization (APO) is a technology that has recently found utility in a multitude of process optimization challenges. In contrast to most…”
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A Holistic Strategy for Cyanide Control and Safety for Pharmaceutical Manufacturing by Zompa, Michael A, Di Maso, Michael J, Guzman, Francisco, Zhao, Ralph, Jellett, Lisa, Arvary, Rebecca, Song, Siqing, Chang, Darryl, Ren, Hong, Lohani, Sachin

“…The manufacturing route toward gefapixant citrate generates a trace amount of cyanide as a byproduct of a reaction employing the reagent chloroacetonitrile. In…”
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Synthesis of Spirobicyclic Pyrazoles by Intramolecular Dipolar Cycloadditions/[1s, 5s] Sigmatropic Rearrangements by Dimirjian, Christine A, Castiñeira Reis, Marta, Balmond, Edward I, Turman, Nolan C, Rodriguez, Elys P, Di Maso, Michael J, Fettinger, James C, Tantillo, Dean J, Shaw, Jared T

“…The formation of fused pyrazoles via intramolecular 1,3-dipolar cycloadditions of diazo intermediates with pendant alkynes is described. A subsequent thermal…”
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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 5: Completion of the API Free Base via a Direct Chlorosulfonylation Process by Di Maso, Michael J, Ren, Hong, Zhang, Si-Wei, Liu, Wenjun, Desmond, Richard, Alwedi, Embarek, Narsimhan, Karthik, Kalinin, Alexei, Larpent, Patrick, Lee, Alfred Y, Ren, Sumei, Maloney, Kevin M

“…A scalable two-pot sulfonamidation through the process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under…”
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Diastereoselective Base-Catalyzed Formal [4 + 2] Cycloadditions of N‑Sulfonyl Imines and Cyclic Anhydrides by Laws, Stephen W, Moore, Lucas C, Di Maso, Michael J, Nguyen, Q. Nhu N, Tantillo, Dean J, Shaw, Jared T

“…A diastereoselective base-catalyzed Mannich reaction of cyclic, enolizable anhydrides and N-sulfonyl imines for the synthesis of δ-lactams is reported. This…”
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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview by Ren, Hong, Maloney, Kevin M, Basu, Kallol, Di Maso, Michael J, Humphrey, Guy R, Peng, Feng, Desmond, Richard, Otte, Douglas A. L, Alwedi, Embarek, Liu, Wenjun, Zhang, Si-Wei, Song, Siqing, Arvary, Rebecca A, Zompa, Michael A, Lehnherr, Dan, Martin, Gary E, Chang, Hsieh Yao D, Mohan, Anne E, Guzman, Francisco J, Jellett, Lisa, Lee, Alfred Y, Spencer, Glenn, Fisher, Elizabeth S, Naber, John R, Gao, Hong, Lohani, Sachin, Ruck, Rebecca T, Campeau, Louis-Charles

“…A robust, green, and sustainable manufacturing process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under…”
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Desymmetrization of Cyclic Sulfonimidamides by Asymmetric Allylation by Gutierrez, David A., Toth‐Williams, Garrett, Laconsay, Croix J., Yasuda, Michael, Fettinger, James C., Di Maso, Michael J., Shaw, Jared T.

“…Herein we report the first transition metal‐catalyzed approach to the enantioenriched synthesis of cyclic sulfonimidamides relying on commercially available…”
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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process by Maloney, Kevin M, Zhang, Si-Wei, Mohan, Anne E, Lee, Alfred Y, Larpent, Patrick, Ren, Hong, Humphrey, Guy R, Desmond, Richard, DiBenedetto, Michael, Liu, Wenjun, Lee, Ivan H, Sirota, Eric, Di Maso, Michael J, Alwedi, Embarek, Song, Siqing, Chang, Hsieh Yao D

“…The development of a sustainable commercial salt formation process for gefapixant citrate (MK-7264), an investigational new P2X3 antagonist for the treatment…”
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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation–Cyclization Sequence to the Diaminopyrimidine Core by Basu, Kallol, Lehnherr, Dan, Martin, Gary E, Desmond, Richard A, Lam, Yu-hong, Peng, Feng, Chung, John Y. L, Arvary, Rebecca A, Zompa, Michael A, Zhang, Si-Wei, Liu, Jinchu, Dance, Zachary E. X, Larpent, Patrick, Cohen, Ryan D, Guzman, Francisco J, Rogus, Nicholas J, Di Maso, Michael J, Ren, Hong, Maloney, Kevin M

“…The development of a safe, robust, and efficient manufacturing route for the synthesis of diaminopyrimidine 1, a key intermediate to gefapixant citrate…”
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Diastereoselective Synthesis of γ- and δ‑Lactams from Imines and Sulfone-Substituted Anhydrides by Sorto, Nohemy A, Di Maso, Michael J, Muñoz, Manuel A, Dougherty, Ryan J, Fettinger, James C, Shaw, Jared T

“…Sulfone-substituted γ- and δ-lactams have been prepared in a single step with high diastereoselectivity. Sulfonylglutaric anhydrides produce intermediates that…”
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Synthesis of a Library of “Lead-Like” γ‑Lactams by a One Pot, Four-Component Reaction by Martin, Kevin S, Di Maso, Michael J, Fettinger, James C, Shaw, Jared T

“…The synthesis of a pilot scale library of 116 structurally diverse γ-lactams is reported. The library core structure emanates from a γ-lactam forming one-pot,…”
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Continuous-Flow Solid-Phase Peptide Synthesis to Enable Rapid, Multigram Deliveries of Peptides by Ruhl, Kyle E., Di Maso, Michael J., Rose, Harrison B., Schultz, Danielle M., Lévesque, François, Grosser, Shane T., Silverman, Steven M., Li, Shasha, Sciammetta, Nunzio, Mansoor, Umar Faruk

“…Peptides may revolutionize the treatment of disease by combining the pharmacological benefits found in both large and small molecules into once-daily oral…”
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Use of a Dynamic Flow Platform To Translate a Batch Immobilized Transaminase Process to a Packed Bed Reactor for the Synthesis of an Intermediate of Nemtabrutinib by Di Maso, Michael J., Kuethe, Jeffrey T., Narsimhan, Karthik, Burris, Matthew, Chung, Cheol K., DiBenedetto, Michael, Forstater, Jacob H., Grosser, Shane T., Kuhl, Nadine, Lévesque, François, Maguire, Anne, Maloney, Kevin M., McMullen, Jonathan P., Prier, Christopher K., Qi, Ji, Rivera, Nelo R., Wang, Zhixun, Wyvratt, Brian M., Zewge, Daniel

“…Herein we describe the translation of an immobilized transaminase process in batch to a packed bed reactor for the synthesis of cyrene amine, an intermediate…”
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