Search Results - "Di Luca, Andrea"
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Redox-coupled quinone dynamics in the respiratory complex I
Published in Proceedings of the National Academy of Sciences - PNAS (04-09-2018)“…Complex I couples the free energy released from quinone (Q) reduction to pump protons across the biological membrane in the respiratory chains of mitochondria…”
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How inter-subunit contacts in the membrane domain of complex I affect proton transfer energetics
Published in Biochimica et biophysica acta. Bioenergetics (01-09-2018)“…The respiratory complex I is a redox-driven proton pump that employs the free energy released from quinone reduction to pump protons across its complete ca…”
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In situ architecture of the ER–mitochondria encounter structure
Published in Nature (London) (01-06-2023)“…The endoplasmic reticulum and mitochondria are main hubs of eukaryotic membrane biogenesis that rely on lipid exchange via membrane contact sites 1 – 3 , but…”
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Symmetry-related proton transfer pathways in respiratory complex I
Published in Proceedings of the National Academy of Sciences - PNAS (01-08-2017)“…Complex I functions as the initial electron acceptor in aerobic respiratory chains of most organisms. This gigantic redox-driven enzyme employs the energy from…”
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Correlating kinetic and structural data on ubiquinone binding and reduction by respiratory complex I
Published in Proceedings of the National Academy of Sciences - PNAS (28-11-2017)“…Respiratory complex I (NADH:ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in mammalian cells, powers ATP synthesis by using the energy…”
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6
Automated feature selection procedure for particle jet classification
Published in Nuclear physics. B (01-05-2023)“…The high dimensionality of the data produced in high-energy physics experiments makes the use of machine learning algorithms, such as neural networks,…”
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7
Structure of inhibitor-bound mammalian complex I
Published in Nature communications (16-10-2020)“…Respiratory complex I (NADH:ubiquinone oxidoreductase) captures the free energy from oxidising NADH and reducing ubiquinone to drive protons across the…”
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8
Deactivation blocks proton pathways in the mitochondrial complex I
Published in Proceedings of the National Academy of Sciences - PNAS (20-07-2021)“…Cellular respiration is powered by membrane-bound redox enzymes that convert chemical energy into an electrochemical proton gradient and drive the energy…”
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9
Structural studies on choline-carboxylate bio-ionic liquids by x-ray scattering and molecular dynamics
Published in The Journal of chemical physics (21-09-2015)“…We report a X-ray diffraction and molecular dynamics study on three choline-based bio-ionic liquids, choline formate, [Ch] [For], choline propanoate,…”
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10
Tuning Cell Differentiation into a 3D Scaffold Presenting a Pore Shape Gradient for Osteochondral Regeneration
Published in Advanced healthcare materials (01-07-2016)“…Osteochondral regeneration remains nowadays a major problem since the outcome of current techniques is not satisfactory in terms of functional tissue formation…”
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Hybrid Polycaprolactone/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans
Published in Advanced healthcare materials (01-07-2016)“…Although regarded as a promising treatment for type 1 diabetes, clinical islet transplantation in the portal vein is still hindered by a low transplantation…”
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12
Amphiphilic beads as depots for sustained drug release integrated into fibrillar scaffolds
Published in Journal of controlled release (10-08-2014)“…Native extracellular matrix (ECM) is a complex fibrous structure loaded with bioactive cues that affects the surrounding cells. A promising strategy to…”
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13
3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering
Published in Regenerative biomaterials (01-02-2019)“…Abstract Additive manufacturing (AM) has shown promise in designing 3D scaffold for regenerative medicine. However, many synthetic biomaterials used for AM are…”
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14
The Scintillation Counters of the High-Energy Particle Detector of the China Seismo-Electromagnetic (CSES-02) Satellite
Published in Remote sensing (Basel, Switzerland) (01-11-2024)“…The High-Energy Particle Detector (HEPD-02) is one of the scientific payloads of the China Seismo-Electromagnetic Satellite (CSES-02). The HEPD-02’s main…”
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Tailorable Surface Morphology of 3D Scaffolds by Combining Additive Manufacturing with Thermally Induced Phase Separation
Published in Macromolecular rapid communications. (01-08-2017)“…The functionalization of biomaterials substrates used for cell culture is gearing towards an increasing control over cell activity. Although a number of…”
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Creeping Proteins in Microporous Structures: Polymer Brush-Assisted Fabrication of 3D Gradients for Tissue Engineering
Published in Advanced healthcare materials (03-06-2015)“…Coupling of rapid prototyping techniques and surface‐confined polymerizations allows the fabrication of 3D multidirectional gradients of biomolecules within…”
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Dual Electrospun Supramolecular Polymer Systems for Selective Cell Migration
Published in Macromolecular bioscience (01-07-2018)“…Dual electrospinning can be used to make multifunctional scaffolds for regenerative medicine applications. Here, two supramolecular polymers with different…”
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Stem-Cell Clinging by a Thread: AFM Measure of Polymer-Brush Lateral Deformation
Published in Advanced materials interfaces (01-02-2016)“…If the binding strength of adhesive cues to the extracellular matrix (ECM) and the mechanisms involved in cell adhesion are synergistically correlated via a…”
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PEOT/PBT Polymeric Pastes to Fabricate Additive Manufactured Scaffolds for Tissue Engineering
Published in Frontiers in bioengineering and biotechnology (14-09-2021)“…The advantages of additive manufactured scaffolds, as custom-shaped structures with a completely interconnected and accessible pore network from the micro- to…”
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Controlled Surface Initiated Polymerization of N-Isopropylacrylamide from Polycaprolactone Substrates for Regulating Cell Attachment and Detachment
Published in Israel journal of chemistry (01-04-2012)“…Poly(ε‐caprolactone) (PCL) substrates were modified with thermoresponsive poly(N‐isopropylacrylamide) (PNIPAM) brushes to direct and control cellular…”
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