Search Results - "Díaz‐Orejas, Ramón"

RNase/Anti-RNase Activities of the Bacterial parD Toxin-Antitoxin System by MUNOZ-GOMEZ, Ana J, LEMONNIER, Marc, SANTOS-SIERRA, Sandra, BERZAL-HERRANZ, Alfredo, DIAZ-OREJAS, Ramon

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Interactions between the toxin Kid of the bacterial parD system and the antitoxins Kis and MazE by Kamphuis, Monique B., Monti, Maria Chiara, van den Heuvel, Robert H. H., Santos-Sierra, Sandra, Folkers, Gert E., Lemonnier, Marc, Díaz-Orejas, Ramón, Heck, Albert J. R., Boelens, Rolf

“…The proteins Kid and Kis are the toxin and antitoxin, respectively, encoded by the parD operon of Escherichia coli plasmid R1. Kis prevents the inhibition of…”
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Identification of Residues of the Kid Toxin Involved in Autoregulation of the parD System by Marc Lemonnier, Sandra Santos-Sierra, Consolación Pardo-Abarrio, Ramón Díaz-Orejas

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Modulation of pPS10 host range by DnaA by Maestro, Beatriz, Sanz, Jesús M., Faelen, Michel, Couturier, Martine, Díaz‐Orejas, Ramón, Fernández‐Tresguerres, Elena

“…Summary Narrow‐host‐range plasmid pPS10, originally found in Pseudomonas savastanoi, is unable to replicate in other strains such as Escherichia coli. Here, we…”
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From the Chief Editor by Orejas, Ramón Díaz

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Stabilization of the Virulence Plasmid pSLT of Salmonella Typhimurium by Three Maintenance Systems and Its Evaluation by Using a New Stability Test by Lobato-Márquez, Damián, Molina-García, Laura, Moreno-Córdoba, Inma, García-Del Portillo, Francisco, Díaz-Orejas, Ramón

“…Certain serovars belonging to subspecies I carry low-copy-number virulence plasmids of variable size (50-90 kb). All of these plasmids share the operon, which…”
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A conformational switch between transcriptional repression and replication initiation in the RepA dimerization domain by Giraldo, Rafael, Fernández-Tornero, Carlos, Evans, Philip R, Díaz-Orejas, Ramón, Romero, Antonio

“…Plasmids are natural vectors for gene transfer. In Gram-negative bacteria, plasmid DNA replication is triggered when monomers of an initiator protein (Rep)…”
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The Importance of the Expendable: Toxin-Antitoxin Genes in Plasmids and Chromosomes by Díaz-Orejas, Ramón, Espinosa, Manuel, Yeo, Chew Chieng

“…Toxin-antitoxin (TA) genes were first reported in plasmids and were considered expendable genetic cassettes involved in the stable maintenance of the plasmid…”
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Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells by Lobato-Márquez, Damián, Moreno-Córdoba, Inmaculada, Figueroa, Virginia, Díaz-Orejas, Ramón, García-del Portillo, Francisco

“…Toxin-antitoxin (TA) modules contribute to the generation of non-growing cells in response to stress. These modules abound in bacterial pathogens although the…”
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Protein domains and conformational changes in the activation of RepA, a DNA replication initiator by Giraldo, Rafael, Andreu, José M., Díaz-Orejas, Ramón

“…RepA is the DNA replication initiator protein of the Pseudomonas plasmid pPS10. RepA has a dual function: as a dimer, it binds to an inversely‐repeated…”
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Replication and Control of Circular Bacterial Plasmids by del Solar, G, Giraldo, R, Ruiz-Echevarría, M J, Espinosa, M, Díaz-Orejas, R

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Comparison of ccd of F, parDE of RP4, and parD of R1 using a novel conditional replication control system of plasmid R1 by Jensen, R B, Grohmann, E, Schwab, H, Díaz-Orejas, R, Gerdes, K

“…A number of plasmid-encoded gene systems are thought to stabilize plasmids by killing plasmid-free cells (also termed post-segregational killing or plasmid…”
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Successful Establishment of Plasmids R1 and pMV158 in a New Host Requires the Relief of the Transcriptional Repression of Their Essential rep Genes by Ruiz-Masó, José Á, Luengo, Luis M, Moreno-Córdoba, Inmaculada, Díaz-Orejas, Ramón, Del Solar, Gloria

“…Although differing in size, encoded traits, host range, and replication mechanism, both narrow-host-range theta-type conjugative enterobacterial plasmid R1 and…”
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Toxin-antitoxins and bacterial virulence by Lobato-Márquez, Damián, Díaz-Orejas, Ramón, García-del Portillo, Francisco

“…Bacterial virulence relies on a delicate balance of signals interchanged between the invading microbe and the host. This communication has been extensively…”
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Broad-host-range plasmid replication: an open question by del Solar, G, Alonso, J C, Espinosa, M, Díaz-Orejas, R

“…Many factors can influence the ability of plasmids to colonize different hosts, efficient replication probably being the most critical one. Two major…”
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The toxin-antitoxin proteins relBE2Spn of Streptococcus pneumoniae: Characterization and association to their DNA target by Moreno-Córdoba, Inma, Diago-Navarro, Elizabeth, Barendregt, Arjan, Heck, Albert J. R., Alfonso, Carlos, Díaz-Orejas, Ramón, Nieto, Concha, Espinosa, Manuel

“…The chromosome of the pathogenic Gram‐positive bacterium Streptococcus pneumoniae contains between six to 10 operons encoding toxin–antitoxin systems (TAS)…”
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Genetic identification of two functional regions in the antitoxin of the parD killer system of plasmid R1 by Santos-Sierra, Sandra, Pardo-Abarrio, Consolación, Giraldo, Rafael, Dı́az-Orejas, Ramón

“…Abstract We report the identification and genetic analysis of mutants in the antitoxin of the parD (kis, kid) killer system of plasmid R1. Missense mutants…”
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Coupling between the basic replicon and the Kis-Kid maintenance system of plasmid R1: modulation by Kis antitoxin levels and involvement in control of plasmid replication by López-Villarejo, Juan, Lobato-Márquez, Damián, Díaz-Orejas, Ramón

“…kis-kid, the auxiliary maintenance system of plasmid R1 and copB, the auxiliary copy number control gene of this plasmid, contribute to increase plasmid…”
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parD toxin-antitoxin system of plasmid R1 - basic contributions, biotechnological applications and relationships with closely-related toxin-antitoxin systems by Diago-Navarro, Elizabeth, Hernandez-Arriaga, Ana M, López-Villarejo, Juan, Muñoz-Gómez, Ana J, Kamphuis, Monique B, Boelens, Rolf, Lemonnier, Marc, Díaz-Orejas, Ramón

“…Toxin-antitoxin systems, as found in bacterial plasmids and their host chromosomes, play a role in the maintenance of genetic information, as well as in the…”
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A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions by Smith, Andrew B, López-Villarejo, Juan, Diago-Navarro, Elizabeth, Mitchenall, Lesley A, Barendregt, Arjan, Heck, Albert J, Lemonnier, Marc, Maxwell, Anthony, Díaz-Orejas, Ramón

“…Bacterial toxin-antitoxin (TA) systems encode two proteins, a potent inhibitor of cell proliferation (toxin) and its specific antidote (antitoxin). Structural…”
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