Search Results - "Di Giorgio, Eros"
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Genetic Programs Driving Oncogenic Transformation: Lessons from in Vitro Models
Published in International journal of molecular sciences (12-12-2019)“…Cancer complexity relies on the intracellular pleiotropy of oncogenes/tumor suppressors and in the strong interplay between tumors and micro- and…”
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2
MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity
Published in The Journal of clinical investigation (01-12-2020)“…The transcription factor MEF2D is important in the regulation of differentiation and adaptive responses in many cell types. We found that among T cells, MEF2D…”
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3
Regulation of class IIa HDAC activities: it is not only matter of subcellular localization
Published in Epigenomics (01-02-2016)“…In response to environmental cues, enzymes that influence the functions of proteins, through reversible post-translational modifications supervise the…”
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4
Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells
Published in Nucleic acids research (24-01-2020)“…Abstract Transcriptional networks supervising class IIa HDAC expression are poorly defined. Here we demonstrate that MEF2D is the key factor controlling HDAC9…”
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5
MEF2 and the tumorigenic process, hic sunt leones
Published in Biochimica et biophysica acta. Reviews on cancer (01-12-2018)“…While MEF2 transcription factors are well known to cooperate in orchestrating cell fate and adaptive responses during development and adult life, additional…”
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Endogenous Retroviruses (ERVs): Does RLR (RIG-I-Like Receptors)-MAVS Pathway Directly Control Senescence and Aging as a Consequence of ERV De-Repression?
Published in Frontiers in immunology (09-06-2022)“…Bi-directional transcription of Human Endogenous Retroviruses (hERVs) is a common feature of autoimmunity, neurodegeneration and cancer. Higher rates of cancer…”
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HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair
Published in Nucleic acids research (12-08-2024)“…Abstract Access to DNA is the first level of control in regulating gene transcription, a control that is also critical for maintaining DNA integrity. Cellular…”
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The Control Operated by the Cell Cycle Machinery on MEF2 Stability Contributes to the Downregulation of CDKN1A and Entry into S Phase
Published in Molecular and cellular biology (01-05-2015)“…MEF2s are pleiotropic transcription factors (TFs) which supervise multiple cellular activities. During the cell cycle, MEF2s are activated at the G 0 /G 1…”
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HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers
Published in Genome Biology (10-05-2021)“…Cellular senescence is a permanent state of replicative arrest defined by a specific pattern of gene expression. The epigenome in senescent cells is sculptured…”
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10
Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity
Published in The Journal of clinical investigation (01-04-2020)“…Foxp3+ Tregs are key to immune homeostasis, but the contributions of various large, multiprotein complexes that regulate gene expression remain unexplored. We…”
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11
The Histone Code of Senescence
Published in Cells (Basel, Switzerland) (18-02-2020)“…Senescence is the end point of a complex cellular response that proceeds through a set of highly regulated steps. Initially, the permanent cell-cycle arrest…”
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Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription
Published in Nucleic acids research (21-03-2022)“…Abstract In leiomyosarcoma class IIa HDACs (histone deacetylases) bind MEF2 and convert these transcription factors into repressors to sustain proliferation…”
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13
Unscheduled HDAC4 repressive activity in human fibroblasts triggers TP53‐dependent senescence and favors cell transformation
Published in Molecular oncology (01-12-2018)“…Expression of the class IIa HDACs is frequently altered in different human cancers. In mouse models these transcriptional repressors can trigger…”
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14
HDAC7‐mediated control of tumour microenvironment maintains proliferative and stemness competence of human mammary epithelial cells
Published in Molecular oncology (01-08-2019)“…HDAC7 is a pleiotropic transcriptional coregulator that controls different cellular fates. Here, we demonstrate that in human mammary epithelial cells, HDAC7…”
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15
GSK3β is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ
Published in Cell death & disease (02-01-2020)“…Signaling pathways controlling necrosis are still mysterious and debated. We applied a shRNA-based viability screen to identify critical elements of the…”
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Unscheduled HDAC 4 repressive activity in human fibroblasts triggers TP 53‐dependent senescence and favors cell transformation
Published in Molecular oncology (01-12-2018)“…Expression of the class II a HDAC s is frequently altered in different human cancers. In mouse models these transcriptional repressors can trigger…”
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Transcription of endogenous retroviruses in senescent cells contributes to the accumulation of double-stranded RNAs that trigger an anti-viral response that reinforces senescence
Published in Cell death & disease (21-02-2024)“…An important epigenetic switch marks the onset and maintenance of senescence. This allows transcription of the genetic programs that arrest the cell cycle and…”
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Enhancing Proteotoxic Stress in Leiomyosarcoma Cells Triggers Mitochondrial Dysfunctions, Cell Death, and Antitumor Activity in vivo
Published in Molecular cancer therapeutics (01-06-2021)“…Leiomyosarcomas are rare and aggressive tumors characterized by a complex karyotype. Surgical resection with or without radiotherapy and chemotherapy is the…”
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T-regulatory cells require Sin3a for stable expression of Foxp3
Published in Frontiers in immunology (02-08-2024)“…Histone deacetylases 1 and 2 play a major role in the transcriptional regulation of T-regulatory (Treg) cells via interactions with a myriad of coregulatory…”
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Dual-targeting peptides@PMO, a mimetic to the pro-apoptotic protein Smac/DIABLO for selective activation of apoptosis in cancer cells
Published in Frontiers in pharmacology (29-08-2023)“…The refractoriness of tumor cells to apoptosis represents the main mechanism of resistance to chemotherapy. Smac/DIABLO mimetics proved to be effective in…”
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