Search Results - "Di Giorgio, Eros"

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  1. 1

    Genetic Programs Driving Oncogenic Transformation: Lessons from in Vitro Models by Giorgio, Eros Di, Paluvai, Harikrishnareddy, Picco, Raffaella, Brancolini, Claudio

    “…Cancer complexity relies on the intracellular pleiotropy of oncogenes/tumor suppressors and in the strong interplay between tumors and micro- and…”
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  2. 2

    MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity by Di Giorgio, Eros, Wang, Liqing, Xiong, Yan, Akimova, Tatiana, Christensen, Lanette M, Han, Rongxiang, Samanta, Arabinda, Trevisanut, Matteo, Bhatti, Tricia R, Beier, Ulf H, Hancock, Wayne W

    Published in The Journal of clinical investigation (01-12-2020)
    “…The transcription factor MEF2D is important in the regulation of differentiation and adaptive responses in many cell types. We found that among T cells, MEF2D…”
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  3. 3

    Regulation of class IIa HDAC activities: it is not only matter of subcellular localization by Di Giorgio, Eros, Brancolini, Claudio

    Published in Epigenomics (01-02-2016)
    “…In response to environmental cues, enzymes that influence the functions of proteins, through reversible post-translational modifications supervise the…”
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  4. 4

    Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells by Di Giorgio, Eros, Dalla, Emiliano, Franforte, Elisa, Paluvai, Harikrishnareddy, Minisini, Martina, Trevisanut, Matteo, Picco, Raffaella, Brancolini, Claudio

    Published in Nucleic acids research (24-01-2020)
    “…Abstract Transcriptional networks supervising class IIa HDAC expression are poorly defined. Here we demonstrate that MEF2D is the key factor controlling HDAC9…”
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  5. 5

    MEF2 and the tumorigenic process, hic sunt leones by Di Giorgio, Eros, Hancock, Wayne W., Brancolini, Claudio

    “…While MEF2 transcription factors are well known to cooperate in orchestrating cell fate and adaptive responses during development and adult life, additional…”
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  6. 6

    Endogenous Retroviruses (ERVs): Does RLR (RIG-I-Like Receptors)-MAVS Pathway Directly Control Senescence and Aging as a Consequence of ERV De-Repression? by Di Giorgio, Eros, Xodo, Luigi E.

    Published in Frontiers in immunology (09-06-2022)
    “…Bi-directional transcription of Human Endogenous Retroviruses (hERVs) is a common feature of autoimmunity, neurodegeneration and cancer. Higher rates of cancer…”
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  7. 7

    HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair by Di Giorgio, Eros, Dalla, Emiliano, Tolotto, Vanessa, D’Este, Francesca, Paluvai, Harikrishnareddy, Ranzino, Liliana, Brancolini, Claudio

    Published in Nucleic acids research (12-08-2024)
    “…Abstract Access to DNA is the first level of control in regulating gene transcription, a control that is also critical for maintaining DNA integrity. Cellular…”
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  8. 8

    The Control Operated by the Cell Cycle Machinery on MEF2 Stability Contributes to the Downregulation of CDKN1A and Entry into S Phase by Di Giorgio, Eros, Gagliostro, Enrico, Clocchiatti, Andrea, Brancolini, Claudio

    Published in Molecular and cellular biology (01-05-2015)
    “…MEF2s are pleiotropic transcription factors (TFs) which supervise multiple cellular activities. During the cell cycle, MEF2s are activated at the G 0 /G 1…”
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  9. 9

    HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers by Di Giorgio, Eros, Paluvai, Harikrishnareddy, Dalla, Emiliano, Ranzino, Liliana, Renzini, Alessandra, Moresi, Viviana, Minisini, Martina, Picco, Raffaella, Brancolini, Claudio

    Published in Genome Biology (10-05-2021)
    “…Cellular senescence is a permanent state of replicative arrest defined by a specific pattern of gene expression. The epigenome in senescent cells is sculptured…”
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  10. 10

    Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity by Xiong, Yan, Wang, Liqing, Di Giorgio, Eros, Akimova, Tatiana, Beier, Ulf H, Han, Rongxiang, Trevisanut, Matteo, Kalin, Jay H, Cole, Philip A, Hancock, Wayne W

    Published in The Journal of clinical investigation (01-04-2020)
    “…Foxp3+ Tregs are key to immune homeostasis, but the contributions of various large, multiprotein complexes that regulate gene expression remain unexplored. We…”
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  11. 11

    The Histone Code of Senescence by Paluvai, Harikrishnareddy, Di Giorgio, Eros, Brancolini, Claudio

    Published in Cells (Basel, Switzerland) (18-02-2020)
    “…Senescence is the end point of a complex cellular response that proceeds through a set of highly regulated steps. Initially, the permanent cell-cycle arrest…”
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  12. 12
  13. 13

    Unscheduled HDAC4 repressive activity in human fibroblasts triggers TP53‐dependent senescence and favors cell transformation by Paluvai, Harikrishnareddy, Di Giorgio, Eros, Brancolini, Claudio

    Published in Molecular oncology (01-12-2018)
    “…Expression of the class IIa HDACs is frequently altered in different human cancers. In mouse models these transcriptional repressors can trigger…”
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  14. 14

    HDAC7‐mediated control of tumour microenvironment maintains proliferative and stemness competence of human mammary epithelial cells by Cutano, Valentina, Di Giorgio, Eros, Minisini, Martina, Picco, Raffaella, Dalla, Emiliano, Brancolini, Claudio

    Published in Molecular oncology (01-08-2019)
    “…HDAC7 is a pleiotropic transcriptional coregulator that controls different cellular fates. Here, we demonstrate that in human mammary epithelial cells, HDAC7…”
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  15. 15

    GSK3β is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ by Ciotti, Sonia, Iuliano, Luca, Cefalù, Sebastiano, Comelli, Marina, Mavelli, Irene, Di Giorgio, Eros, Brancolini, Claudio

    Published in Cell death & disease (02-01-2020)
    “…Signaling pathways controlling necrosis are still mysterious and debated. We applied a shRNA-based viability screen to identify critical elements of the…”
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  16. 16

    Unscheduled HDAC 4 repressive activity in human fibroblasts triggers TP 53‐dependent senescence and favors cell transformation by Paluvai, Harikrishnareddy, Di Giorgio, Eros, Brancolini, Claudio

    Published in Molecular oncology (01-12-2018)
    “…Expression of the class II a HDAC s is frequently altered in different human cancers. In mouse models these transcriptional repressors can trigger…”
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  17. 17

    Transcription of endogenous retroviruses in senescent cells contributes to the accumulation of double-stranded RNAs that trigger an anti-viral response that reinforces senescence by Di Giorgio, Eros, Ranzino, Liliana, Tolotto, Vanessa, Dalla, Emiliano, Burelli, Matteo, Gualandi, Nicolò, Brancolini, Claudio

    Published in Cell death & disease (21-02-2024)
    “…An important epigenetic switch marks the onset and maintenance of senescence. This allows transcription of the genetic programs that arrest the cell cycle and…”
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    T-regulatory cells require Sin3a for stable expression of Foxp3 by Christensen, Lanette M, Akimova, Tatiana, Wang, Liqing, Han, Rongxiang, Samanta, Arabinda, Di Giorgio, Eros, Hancock, Wayne W

    Published in Frontiers in immunology (02-08-2024)
    “…Histone deacetylases 1 and 2 play a major role in the transcriptional regulation of T-regulatory (Treg) cells via interactions with a myriad of coregulatory…”
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  20. 20

    Dual-targeting peptides@PMO, a mimetic to the pro-apoptotic protein Smac/DIABLO for selective activation of apoptosis in cancer cells by Di Giorgio, Eros, Ferino, Annalisa, Huang, Weizhe, Simonetti, Sigrid, Xodo, Luigi, De Marco, Rossella

    Published in Frontiers in pharmacology (29-08-2023)
    “…The refractoriness of tumor cells to apoptosis represents the main mechanism of resistance to chemotherapy. Smac/DIABLO mimetics proved to be effective in…”
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