Search Results - "Di Giacomo, Filomena"

Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma by Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Ercole, Elisabetta, Todaro, Maria, Boi, Michela, Acquaviva, Andrea, Ficarra, Elisa, Novero, Domenico, Rinaldi, Andrea, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Cerroni, Lorenzo, Tzankov, Alexander, Ponzoni, Maurilio, Paulli, Marco, Weisenburger, Dennis, Chan, Wing C., Iqbal, Javeed, Piris, Miguel A., Zamo’, Alberto, Ciardullo, Carmela, Rossi, Davide, Gaidano, Gianluca, Pileri, Stefano, Tiacci, Enrico, Falini, Brunangelo, Shultz, Leonard D., Mevellec, Laurence, Vialard, Jorge E., Piva, Roberto, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio

“…A systematic characterization of the genetic alterations driving ALCLs has not been performed. By integrating massive sequencing strategies, we provide a…”
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Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms by Circosta, Paola, Elia, Angela Rita, Landra, Indira, Machiorlatti, Rodolfo, Todaro, Maria, Aliberti, Sabrina, Brusa, Davide, Deaglio, Silvia, Chiaretti, Sabina, Bruna, Riccardo, Gottardi, Daniela, Massaia, Massimo, Giacomo, Filomena Di, Guarini, Anna Rita, Foà, Robin, Kyriakides, Peter W., Bareja, Rohan, Elemento, Olivier, Chichili, Gurunadh R., Monteleone, Emanuele, Moore, Paul A., Johnson, Syd, Bonvini, Ezio, Cignetti, Alessandro, Inghirami, Giorgio

“…Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using…”
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Rapid identification of BCR/ABL1‐like acute lymphoblastic leukaemia patients using a predictive statistical model based on quantitative real time‐polymerase chain reaction: clinical, prognostic and therapeutic implications by Chiaretti, Sabina, Messina, Monica, Grammatico, Sara, Piciocchi, Alfonso, Fedullo, Anna L., Di Giacomo, Filomena, Peragine, Nadia, Gianfelici, Valentina, Lauretti, Alessia, Bareja, Rohan, Martelli, Maria P., Vignetti, Marco, Apicella, Valerio, Vitale, Antonella, Li, Loretta S., Salek, Cyril, Elemento, Olivier, Inghirami, Giorgio, Weinstock, David M., Guarini, Anna, Foà, Robin

“…Summary BCR/ABL1‐like acute lymphoblastic leukaemia (ALL) is a subgroup of B‐lineage acute lymphoblastic leukaemia that occurs within cases without recurrent…”
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Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma by Tabbò, Fabrizio, Nottegar, Alessia, Guerrera, Francesco, Migliore, Enrica, Luchini, Claudio, Maletta, Francesca, Veronese, Nicola, Montagna, Licia, Gaudiano, Marcello, Di Giacomo, Filomena, Filosso, Pier Luigi, Delsedime, Luisa, Ciccone, Giovannino, Scarpa, Aldo, Sapino, Anna, Oliaro, Alberto, Ruffini, Enrico, Inghirami, Giorgio, Chilosi, Marco

“…Strong prognostic markers able to stratify lung adenocarcinoma (ADC) patients are lacking. We evaluated whether a six-immunohistochemical markers panel (TTF1,…”
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RNA sequencing unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications by Gianfelici, Valentina, Chiaretti, Sabina, Demeyer, Sofie, Di Giacomo, Filomena, Messina, Monica, La Starza, Roberta, Peragine, Nadia, Paoloni, Francesca, Geerdens, Ellen, Pierini, Valentina, Elia, Loredana, Mancini, Marco, De Propris, Maria Stefania, Apicella, Valerio, Gaidano, Gianluca, Testi, Anna Maria, Vitale, Antonella, Vignetti, Marco, Mecucci, Cristina, Guarini, Anna, Cools, Jan, Foà, Robin

“…Despite therapeutic improvements, a sizable number of patients with T-cell acute lymphoblastic leukemia still have a poor outcome. To unravel the genomic…”
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Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma by Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Ercole, Elisabetta, Todaro, Maria, Boi, Michela, Acquaviva, Andrea, Ficarra, Elisa, Novero, Domenico, Rinaldi, Andrea, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Cerroni, Lorenzo, Tzankov, Alexander, Ponzoni, Maurilio, Paulli, Marco, Weisenburger, Dennis, Chan, Wing C., Iqbal, Javeed, Piris, Miguel A., Zamo’, Alberto, Ciardullo, Carmela, Rossi, Davide, Gaidano, Gianluca, Pileri, Stefano, Tiacci, Enrico, Falini, Brunangelo, Shultz, Leonard D., Mevellec, Laurence, Vialard, Jorge E., Piva, Roberto, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio

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Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes by Messina, Monica, Chiaretti, Sabina, Wang, Jiguang, Fedullo, Anna Lucia, Peragine, Nadia, Gianfelici, Valentina, Piciocchi, Alfonso, Brugnoletti, Fulvia, Di Giacomo, Filomena, Pauselli, Simona, Holmes, Antony B, Puzzolo, Maria Cristina, Ceglie, Giulia, Apicella, Valerio, Mancini, Marco, Te Kronnie, Geertruy, Testi, Anna Maria, Vitale, Antonella, Vignetti, Marco, Guarini, Anna, Rabadan, Raul, Foà, Robin

“…To shed light into the molecular bases of B-lineage acute lymphoblastic leukemia lacking known fusion transcripts, i.e. BCR-ABL1, ETV6-RUNX1, E2A-PBX1, and MLL…”
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Endothelial cell–leukemia interactions remodel drug responses, uncovering T-ALL vulnerabilities by Cappelli, Luca Vincenzo, Fiore, Danilo, Phillip, Jude M., Yoffe, Liron, Di Giacomo, Filomena, Chiu, William, Hu, Yang, Kayembe, Clarisse, Ginsberg, Michael, Consolino, Lorena, Barcia Duran, Jose Gabriel, Zamponi, Nahuel, Melnick, Ari M., Boccalatte, Francesco, Tam, Wayne, Elemento, Olivier, Chiaretti, Sabina, Guarini, Anna, Foà, Robin, Cerchietti, Leandro, Rafii, Shahin, Inghirami, Giorgio

“…•We identified active compounds in a library of 22 T-ALL PDX and discovered public and private vulnerabilities•Interacting ECs and T-ALL underwent reciprocal…”
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A Predictive Endothelial-Leukemia Pre-Clinical Platform to Uncover Drug Vulnerabilities for Personalized Treatments by Cappelli, Luca Vincenzo, Fiore, Danilo, Phillip, Jude M, Yoffe, Liron, Di Giacomo, Filomena, Hu, Yang, Kayembe, Clarisse, Ginsberg, Michael, Consolino, Lorena, Barcia Durán, José Gabriel, Zamponi, Nahuel, Melnick, Ari, Boccalatte, Francesco, Tam, Wayne, Elemento, Olivier, Chiaretti, Sabina, Guarini, Anna, Foa, Robin, Cerchietti, Leandro, Rafii, Shahin, Inghirami, Giorgio

“…Background. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with few innovative treatment options. This is also contributed by the lack of…”
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IL7R overexpression in adult acute lymphoblastic leukemia is associated to JAK/STAT pathway mutations and identifies patients who could benefit from targeted therapies by Gianfelici, Valentina, Messina, Monica, Paoloni, Francesca, Peragine, Nadia, Lauretti, Alessia, Fedullo, Anna Lucia, Di Giacomo, Filomena, Vignetti, Marco, Vitale, Antonella, Guarini, Anna, Chiaretti, Sabina, Foà, Robin

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Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency by Ceccon, M, Merlo, M E Boggio, Mologni, L, Poggio, T, Varesio, L M, Menotti, M, Bombelli, S, Rigolio, R, Manazza, A D, Di Giacomo, F, Ambrogio, C, Giudici, G, Casati, C, Mastini, C, Compagno, M, Turner, S D, Gambacorti-Passerini, C, Chiarle, R, Voena, C

“…Most of the anaplastic large-cell lymphoma (ALCL) cases carry the t(2;5; p23;q35) that produces the fusion protein NPM-ALK (nucleophosmin-anaplastic lymphoma…”
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Rapid identification of BCR / ABL 1 ‐like acute lymphoblastic leukaemia patients using a predictive statistical model based on quantitative real time‐polymerase chain reaction: clinical, prognostic and therapeutic implications by Chiaretti, Sabina, Messina, Monica, Grammatico, Sara, Piciocchi, Alfonso, Fedullo, Anna L., Di Giacomo, Filomena, Peragine, Nadia, Gianfelici, Valentina, Lauretti, Alessia, Bareja, Rohan, Martelli, Maria P., Vignetti, Marco, Apicella, Valerio, Vitale, Antonella, Li, Loretta S., Salek, Cyril, Elemento, Olivier, Inghirami, Giorgio, Weinstock, David M., Guarini, Anna, Foà, Robin

“…BCR / ABL 1 ‐like acute lymphoblastic leukaemia ( ALL ) is a subgroup of B‐lineage acute lymphoblastic leukaemia that occurs within cases without recurrent…”
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Generation and Application of T-Cell Lymphoma Patient Derived Tumor Xenograft Models by Fiore, Danilo, Wang, Xujun, Khodos, Inna, Di Giacomo, Filomena, Gaudiano, Marcello, Phillip, Jude M, Wang, Rui, Yang, Zhiwei, Ginsberg, Michael, Intlekofer, Andrew M, Thompson, Craig B., Aster, Jon C., Ruan, Jia, Ng, Samuel Y., Jacobsen, Eric, Dogan, Ahmet, de Stanchina, Elisa, Mattar, Marissa, Cerchietti, Leandro, Bareja, Rohan, Elemento, Olivier, Tam, Wayne, Weinstock, David M., Rafii, Shahin, Horwitz, Steven M., Inghirami, Giorgio

“…Introduction: Although pivotal “driver mutations” have been described in T-cell lymphomas (T-NHL), targetable dependences are lacking for many entities. As…”
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Abstract 131: ALK oncogene regulates epithelial-mesenchymal transition (EMT) in ALK-rearranged non-small cell lung carcinoma through repression of the epithelial splicing regulatory proteins 1 and 2 (ESRP1 and ESRP2) by Voena, Claudia, Varesio, Lydia, Zhang, Liye, Menotti, Matteo, Poggio, Teresa, Di Giacomo, Filomena, Panizza, Elena, Mastini, Cristina, Compagno, Mara, Monti, Stefano, Chiarle, Roberto

“…A subset of Non-Small Cell Lung Carcinoma (NSCLC) carries chromosomal rearrangements involving the Anaplastic Lymphoma Kinase (ALK) gene. More frequently ALK…”
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Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors by Voena, Claudia, Menotti, Matteo, Mastini, Cristina, Di Giacomo, Filomena, Longo, Dario Livio, Castella, Barbara, Merlo, Maria Elena Boggio, Ambrogio, Chiara, Wang, Qi, Minero, Valerio Giacomo, Poggio, Teresa, Martinengo, Cinzia, D'Amico, Lucia, Panizza, Elena, Mologni, Luca, Cavallo, Federica, Altruda, Fiorella, Butaney, Mohit, Capelletti, Marzia, Inghirami, Giorgio, Jänne, Pasi A, Chiarle, Roberto

“…Non-small cell lung cancer (NSCLC) harboring chromosomal rearrangements of the anaplastic lymphoma kinase (ALK) gene is treated with ALK tyrosine kinase…”
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The Pro-Tumorigenic Vascular Niche Sustains the T-Cell Acute Lymphoblastic Leukemia Phenotype and Fosters Resistance to Therapy by Di Giacomo, Filomena, Wang, Xujun, Fiore, Danilo, Consolino, Lorena, Phillip, Jude, Gaudiano, Marcello, Roman-Gonzalez, Lydia, Crescenzo, Ramona, Chiaretti, Sabina, Gianfelici, Valentina, Michael, Ginsberg, Duran, Jose Gabriel Barcia, Salinero, Jesus Maria Gomez, Bareja, Rohan, Elemento, Olivier, Guarini, Anna, Foà, Robin, Cerchietti, Leandro, Rafii, Shahin, Inghirami, Giorgio

“…Introduction. T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous malignancy associated with a high risk of treatment failure. Efforts…”
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Convergent Mutations and New Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma by Crescenzo, Ramona, Abate, Francesco, Lasorsa, Elena, Tabbo’, Fabrizio, Gaudiano, Marcello, Chiesa, Nicoletta, Di Giacomo, Filomena, Spaccarotella, Elisa, Barbarossa, Luigi, Todaro, Maria, Boi, Michela, Tousseyn, Thomas, Rosenwald, Andreas, Kenner, Lukas, Rossi, Davide, Mevellec, Laurence, Vialard, Jorge, Bertoni, Francesco, Rabadan, Raul, Inghirami, Giorgio

“…Introduction. If the role of ALK chimeras is well known in the pathogenesis of ALK+ Anaplastic Large Cell Lymphoma (ALCL), the mechanisms leading to the…”
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ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma by Tabbó, Fabrizio, Barreca, Antonella, Piva, Roberto, Inghirami, Giorgio

“…The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition…”
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