Search Results - "Dhudashiya, Amit A."

A Rationally Designed Peptide Antagonist of the PD-1 Signaling Pathway as an Immunomodulatory Agent for Cancer Therapy by Sasikumar, Pottayil G, Ramachandra, Raghuveer K, Adurthi, Srinivas, Dhudashiya, Amit A, Vadlamani, Sureshkumar, Vemula, Koteswararao, Vunnum, Sriharibabu, Satyam, Leena K, Samiulla, Dodderi S, Subbarao, Krishnaprasad, Nair, Rashmi, Shrimali, Rajeev, Gowda, Nagaraj, Ramachandra, Murali

“…Pioneering success of antibodies targeting immune checkpoints such as PD-1 and CTLA4 has opened novel avenues for cancer immunotherapy. Along with impressive…”
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PD-1 derived CA-170 is an oral immune checkpoint inhibitor that exhibits preclinical anti-tumor efficacy by Sasikumar, Pottayil G., Sudarshan, Naremaddepalli S., Adurthi, Srinivas, Ramachandra, Raghuveer K., Samiulla, Dodderi S., Lakshminarasimhan, Anirudha, Ramanathan, Anuradha, Chandrasekhar, Talapaneni, Dhudashiya, Amit A., Talapati, Sumalatha R., Gowda, Nagesh, Palakolanu, Sreenivasulareddy, Mani, Jiju, Srinivasrao, Bandi, Joseph, David, Kumar, Nigam, Nair, Rashmi, Atreya, Hanudatta S., Gowda, Nagaraj, Ramachandra, Murali

“…Small molecule immune checkpoint inhibitors targeting PD-1 and other pathways may offer advantages including ease of dosing, ability to manage immune-related…”
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Abstract 4148: An orally bioavailable small molecule antagonist of TIM-3 signaling pathway shows potent anti-tumor activity by Sasikumar, Pottayil G., Naremaddepalli, Sudarshan S., Ramachandra, Raghuveer K., Gowda, Nagesh, Devarapalli, Srinivaskumar, Adurthi, Sreenivas, Mani, Jiju, Nair, Rashmi, Dhudashiya, Amit A., Samiulla, Dodheri S., Gowda, Nagaraj M., Ramachandra, Murali

“…Abstract Activation of anti-tumor immune response by specific inhibition of PD1 pathway using monoclonal antibodies has now become of the mainstay in cancer…”
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Abstract 4418: Pharmacological characterization of a preclinical candidate covalently inhibiting CDK12 by Poddutoori, Ramulu, Rajagopalan, Sujatha, Mukherjee, Subhendu, Marappan, Sivapriya, D. S., Samiulla, Sivakumar, Sasirekha, Nayak, Shilpa S, M V, Ravindra, TS, Devaraja, Kondela, Srinivas, Tgore, Suraj, Dhudashiya, Amit A, K. B, Charamanna, A B, Aravind, A, Amith, S, Pavithra, Pathange, Hema Sankar, Antony, Thomas, Jaleel, Mahaboobi, Giri, Sanjeev, Daginakatte, Girish, Nellore, Kavitha, Chelur, Shekar, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Cyclin-dependent kinase 12 (CDK12) is a transcription-associated protein that plays a critical role in DNA damage response, splicing, pre-mRNA…”
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Abstract 6537: A novel CCR4 antagonist induces potent anti-tumor response through inhibition of Treg migration into the tumor microenvironment by Nair, Rashmi, Abbineni, Chandrasekhar, Talluri, Krishna Chaitanya, Dhudashiya, Amit A, AB, Aravind, R, Naveen Kumar, R, Ramya, Balasubramanyam, D, Obanna, Pathur, Madhaiyan, Rabin, Samiulla, DS, Daginakatte, Girish, Narayanan, Kishore, Nellore, Kavitha, Chelur, Shekar, Samajdar, Susanta, Ramachandra, Murali

“…Abstract Regulatory T cells (Tregs), an immunosuppressive subset of CD4+ T cells, play a vital role in maintaining immune homeostasis by regulating response to…”
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Abstract B007: Potent antitumor activity of a novel and orally available small-molecule antagonist targeting the CD47/SIRPα pathway by Sasikumar, Pottayil G., Gundala, Chennakrishnareddy, Balasubramanian, Wesley R., Naremaddepalli, Sudarshan S., Bhumireddy, Archana, Patil, Sandeep S., Dhudashiya, Amit A., Rayavarapu, Vijaysai, Lakshminarasimhan, Anirudha, Samiulla, Dodheri S., Aithal, Kiran, Daginakatte, Girish, Ramachandra, Murali

“…Abstract Antibodies targeting PD-1 and PD-L1 towards stimulation of T cells have revolutionized cancer therapy because of the highly durable response in…”
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Abstract 2384: Preclinical evaluation of PD and efficacy of novel potent selective and orally bioavailable CDK12 covalent inhibitors in TNBC model by Poddutoori, Ramulu, Rajagopalan, Sujatha, Mukherjee, Subhendu, Marappan, Sivapriya, S, Samiulla D, Sivakumar, Sasirekha, Nayak, Shilpa S., V, Ravindra M., Murtuza, Hadianawala, S, Devaraja T., Kondela, Srinivas, Tgore, Suraj, Dhudashiya, Amit A., B, Charamanna K., Antony, Thomas, Daginakatte, Girish, Giri, Sanjeev, Chelur, Shekar, Ramachandra, Murali, Pandit, Chetan, Samajdar, Susanta

“…Abstract Cyclin-dependent kinase 12 (CDK12) is a transcription-associated kinase that participates in various cellular processes such as DNA damage response,…”
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Abstract 3729: Discovery of orally bioavailable SMARCA2/4 dual degraders for treatment of acute myeloid leukemia by Abbineni, Chandrasekhar, Khare, Leena, Kuila, Bilash, Khaji, Abdul Rawoof, Mahadeo, Dhaytadak Bhagwan, Dukare, Sandeep Vitthal, Kumar, Bhagya M S, Gore, Suraj T, Ahuja, Vijay Kamal, Dhudashiya, Amit A, N R, Raghavendra, Gowda, Nagesh, K B, Charamanna, Aithal B, Kiran, D S, Samiulla, Mukherjee, Subhendu, Antony, Thomas, Giri, Sanjeev, Chelur, Shekar, Nellore, Kavitha, Daginakatte, Girish, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: The BAF (SWI/SNF) chromatin remodeling complex comprises of two mutually exclusive ATPases, SMARCA2 (BRM) and SMARCA4 (BRG1), that affect…”
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Abstract 4114: Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers by Abbineni, Chandrasekhar, Thiyagarajan, Saravanan, A B, Aravind, Dhudashiya, Amit A, Marappan, Sivapriya, Kumar R, Naveen, N R, Raghavendra, Dey, Mamon, Kumar, Avinash, B V, Uma Bharathi, Renukappa, Girish Aggunda, Reddy, N Venkata Siva, Babu, Asha, Shetty, Aakanksha J, A, Amith, Rao K, Narasimha, Gore, Suraj T, Jaleel, Mahaboobi, Senaiar, Ramesh S, Nataraj, Vijaya Shankar, Mukherjee, Subhendu, D S, Samiulla, Antony, Thomas, Daginakatte, Girish, Eswarappa, Rajesh, Nellore, Kavitha, Chelur, Shekar, Ramachandra, Murali, Samajdar, Susanta

“…Abstract Background: E1A binding protein (p300) and its paralog CREB binding protein (CBP or CREBBP) are ubiquitously expressed acetyl transferases (HAT) that…”
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Abstract B294: Antitumor efficacy of AUR-012, a peptide antagonist of the PD1 immune checkpoint pathway, correlates well with the modulation of specific T-cell populations by Ramachandra, Murali, Sasikumar, Pottayil G., Shrimali, Rajeev K., Adurthi, Sreenivas, Ramachandra, Raghuveer, Satyam, Leena K., Dhudashiya, Amit A., Samiulla, Dodheri S., Sunilkumar, K B

“…Abstract Recent breakthroughs in achieving highly durable clinical responses via immunotherapy to inhibit immune checkpoint proteins including CTLA4 and PD1…”
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