Search Results - "Dhopeshwarkar, Amey"

Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal by Li, Ai-Ling, Lin, Xiaoyan, Dhopeshwarkar, Amey S, Thomaz, Ana Carla, Carey, Lawrence M, Liu, Yingpeng, Nikas, Spyros P, Makriyannis, Alexandros, Mackie, Ken, Hohmann, Andrea G

“…AM1710 (3-(1,1-dimethyl-heptyl)-1-hydroxy-9-methoxy-benzo(c) chromen-6-one), a cannabilactone cannabinoid receptor 2 (CB2) agonist, suppresses…”
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Slowly Signaling G Protein-Biased CB 2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence by Lin, Xiaoyan, Dhopeshwarkar, Amey S, Huibregtse, Megan, Mackie, Ken, Hohmann, Andrea G

“…The CB cannabinoid agonist LY2828360 lacked both toxicity and efficacy in a clinical trial for osteoarthritis. Whether LY2828360 suppresses neuropathic pain…”
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Where’s my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol by Murataeva, Natalia, Dhopeshwarkar, Amey, Yin, Danielle, Mitjavila, José, Bradshaw, Heather, Straiker, Alex, Mackie, Ken

“…[Display omitted] 2-Arachidonoylglycerol (2-AG) is the most abundant endogenous cannabinoid in the brain and an agonist at two cannabinoid receptors (CB1 and…”
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Microbiome variations induced by delta9-tetrahydrocannabinol predict weight reduction in obese mice by Kaye, Avi, Rusling, Matthew, Dhopeshwarkar, Amey, Kumar, Parhesh, Wagment-Points, Lauren, Mackie, Kenneth, Yuan, Li-Lian

“…Introduction Obesity and high-fat diets induce consistent alterations in gut microbiota composition. Observations from epidemiological reviews and experiments…”
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CB2 Cannabinoid receptors as a therapeutic target-what does the future hold? by Dhopeshwarkar, Amey, Mackie, Ken

“…The past decades have seen an exponential rise in our understanding of the endocannabinoid system, comprising CB1 and CB2 cannabinoid receptors, endogenous…”
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The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: Inhibition by phthalate esters in vitro by Bisset, Kathleen M., Dhopeshwarkar, Amey S., Liao, Chengyong, Nicholson, Russell A.

“…► Phthalate diesters inhibit [3H]CP-55940 and [3H]SR141716A binding to brain CB1-Rs. ► Phthalate monoesters are less effective inhibitors of [3H]radioligand…”
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The actions of benzophenanthridine alkaloids, piperonyl butoxide and (S)-methoprene at the G-protein coupled cannabinoid CB1 receptor in vitro by Dhopeshwarkar, Amey S., Jain, Saurabh, Liao, Chengyong, Ghose, Sudip K., Bisset, Kathleen M., Nicholson, Russell A.

“…This investigation focused primarily on the interaction of two benzophenanthridine alkaloids (chelerythrine and sanguinarine), piperonyl butoxide and…”
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Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway by Dhopeshwarkar, Amey, Mackie, Ken

“…The CB2 cannabinoid receptor (CB2) remains a tantalizing, but unrealized therapeutic target. CB2 receptor ligands belong to varied structural classes and…”
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Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists by Dhopeshwarkar, Amey, Murataeva, Natalia, Makriyannis, Alex, Straiker, Alex, Mackie, Ken

“…The cannabinoid signaling system includes two G protein-coupled receptors, CB and CB These receptors are widely distributed throughout the body and have each…”
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A. Muciniphila; a Microbiome Mediator of Tetrahydrocannabinol Induced Weight Loss? by Rusling, Matthew, Lampeter, Thomas, Fung, Calvin, Love, Charles, Dhopeshwarkar, Amey, Mackie, Ken, Yuan, Li‐Lian

“…Intro The gut microbiome is increasingly known to play a role in obesity; a major health concern globally. It has been noted that cannabis users tend to have…”
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Benzophenanthridine alkaloid, piperonyl butoxide and (S)-methoprene action at the cannabinoid-1 receptor (CB1-receptor) pathway of mouse brain: Interference with [3H]CP55940 and [3H]SR141716A binding and modification of WIN55212-2-dependent inhibition of synaptosomal l-glutamate release by Dhopeshwarkar, Amey Sadashiv, Nicholson, Russell Alfred

“…Benzophenanthridine alkaloids (chelerythrine and sanguinarine) inhibited binding of [3H]SR141716A to mouse brain membranes (IC50s: <1µM). Piperonyl butoxide…”
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Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing by Murataeva, Natalia, Miller, Sally, Dhopeshwarkar, Amey, Leishman, Emma, Daily, Laura, Taylor, Xavier, Morton, Brian, Lashmet, Matthew, Bradshaw, Heather, Hillard, Cecilia J., Romero, Julian, Straiker, Alex

“…CB2R receptors have demonstrated beneficial effects in wound healing in several models. We therefore investigated a potential role of CB2R receptors in corneal…”
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Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea by Murataeva, Natalia, Daily, Laura, Taylor, Xavier, Dhopeshwarkar, Amey, Hu, Sherry Shu-Jung, Miller, Sally, McHugh, Douglas, Oehler, Olivia, Li, Shimin, Bonanno, Joseph A, Mackie, Ken, Straiker, Alex

“…PURPOSE:We previously showed that cannabinoid-related GPR18 receptors are present in the murine corneal epithelium, but their function remains unknown. The…”
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Cannabinoid-induced chemotaxis in bovine corneal epithelial cells by Murataeva, Natalia, Li, Shimin, Oehler, Olivia, Miller, Sally, Dhopeshwarkar, Amey, Hu, Sherry Shu-Jung, Bonanno, Joseph A, Bradshaw, Heather, Mackie, Ken, McHugh, Douglas, Straiker, Alex

“…Cannabinoid CB1 receptors are found in abundance in the vertebrate eye, with most tissue types expressing this receptor. However, the function of CB1 receptors…”
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Synthesis of Photoswitchable Δ9‑Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling by Westphal, Matthias V, Schafroth, Michael A, Sarott, Roman C, Imhof, Michael A, Bold, Christian P, Leippe, Philipp, Dhopeshwarkar, Amey, Grandner, Jessica M, Katritch, Vsevolod, Mackie, Ken, Trauner, Dirk, Carreira, Erick M, Frank, James A

“…The cannabinoid receptor 1 (CB1) is an inhibitory G protein-coupled receptor abundantly expressed in the central nervous system. It has rich pharmacology and…”
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Synthesis of Photoswitchable Δ 9 -Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling by Westphal, Matthias V, Schafroth, Michael A, Sarott, Roman C, Imhof, Michael A, Bold, Christian P, Leippe, Philipp, Dhopeshwarkar, Amey, Grandner, Jessica M, Katritch, Vsevolod, Mackie, Ken, Trauner, Dirk, Carreira, Erick M, Frank, James A

“…The cannabinoid receptor 1 (CB1) is an inhibitory G protein-coupled receptor abundantly expressed in the central nervous system. It has rich pharmacology and…”
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Actions of benzophenanthridine alkaloids and various synthetic compounds on the cannabinoid-1 (CB1) receptor pathway of mouse brain with particular reference to the effects on [3H]CP55940 and [3H]SR141716A binding, interference with basal and CP55940-stimulated [35S]GTPγS binding, and modification of WIN55212-2-dependent inhibition of L-glutamate release from synaptosomes by Dhopeshwarkar, Amey S

“…Benzophenanthridine alkaloids (chelerythrine and sanguinarine) inhibited the binding of [3H]CP55940 and [3H]SR141716A to mouse brain membranes (IC50is approx…”
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