Search Results - "Dhillo, W. S"

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans by Salem, V., Izzi-Engbeaya, C., Coello, C., Thomas, D. B., Chambers, E. S., Comninos, A. N., Buckley, A., Win, Z., Al-Nahhas, A., Rabiner, E. A., Gunn, R. N., Budge, H., Symonds, M. E., Bloom, S. R., Tan, T. M., Dhillo, W. S.

“…Aims To investigate, for a given energy expenditure (EE) rise, the differential effects of glucagon infusion and cold exposure on brown adipose tissue (BAT)…”
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Ghrelin enhances appetite and increases food intake in humans by WREN, A. M, SEAL, L. J, COHEN, M. A, BRYNES, A. E, FROST, G. S, MURPHY, K. G, DHILLO, W. S, GHATEI, M. A, BLOOM, S. R

“…Ghrelin is a recently identified endogenous ligand for the growth hormone secretagogue receptor. It is synthesized predominantly in the stomach and found in…”
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The direct and indirect effects of kisspeptin-54 on granulosa lutein cell function by Owens, L A, Abbara, A, Lerner, A, O'floinn, S, Christopoulos, G, Khanjani, S, Islam, R, Hardy, K, Hanyaloglu, A C, Lavery, S A, Dhillo, W S, Franks, S

“…Abstract STUDY QUESTION What are the in vivo and in vitro actions of kisspeptin-54 on the expression of genes involved in ovarian reproductive function,…”
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Central and Peripheral Administration of Kisspeptin-10 Stimulates the Hypothalamic-Pituitary-Gonadal Axis by Thompson, E. L., Patterson, M., Murphy, K. G., Smith, K. L., Dhillo, W. S., Todd, J. F., Ghatei, M. A., Bloom, S. R.

“…Kisspeptin is the peptide product of the KiSS‐1 gene and the endogenous agonist for the GPR54 receptor. Recent evidence suggests the kisspeptin/GPR54 system is…”
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Reduced Levels of Plasma Kisspeptin During the Antenatal Booking Visit Are Associated With Increased Risk of Miscarriage by Jayasena, C. N, Abbara, A, Izzi-Engbeaya, C, Comninos, A. N, Harvey, R. A, Gonzalez Maffe, J, Sarang, Z, Ganiyu-Dada, Z, Padilha, A. I, Dhanjal, M, Williamson, C, Regan, L, Ghatei, M. A, Bloom, S. R, Dhillo, W. S

“…Context: Kisspeptin is a recently identified hormone encoded by the KISS1 gene, playing a critical role in human reproduction. Plasma kisspeptin levels rise…”
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Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing by Moss, C., Dhillo, W. S., Frost, G., Hickson, M.

“…Loss of appetite is frequently observed during ageing, termed the ‘anorexia of ageing’. Ageing is associated with the inability to appropriately increase food…”
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Twice-Weekly Administration of Kisspeptin-54 for 8 Weeks Stimulates Release of Reproductive Hormones in Women With Hypothalamic Amenorrhea by Jayasena, C N, Nijher, G M K, Abbara, A, Murphy, K G, Lim, A, Patel, D, Mehta, A, Todd, C, Donaldson, M, Trew, G H, Ghatei, M A, Bloom, S R, Dhillo, W S

“…Kisspeptin is a novel therapeutic target for infertility. A single kisspeptin‐54 (KP‐54) injection acutely stimulates the release of reproductive hormones in…”
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A single injection of kisspeptin-54 temporarily increases luteinizing hormone pulsatility in healthy women by Jayasena, C. N., Comninos, A. N., Veldhuis, J. D., Misra, S., Abbara, A., Izzi-Engbeaya, C., Donaldson, M., Ghatei, M. A., Bloom, S. R., Dhillo, W. S.

“…Summary Background Kisspeptin is a novel hypothalamic peptide which stimulates endogenous gonadotrophin releasing hormone (GnRH) secretion. A single…”
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Gut hormones and appetite control by Hameed, S, Dhillo, WS, Bloom, SR

“…The gastrointestinal tract is the largest endocrine organ in the body. It secretes more than 20 different peptide hormones, which serve both a local regulatory…”
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The effects of long-term growth hormone and insulin-like growth factor-1 exposure on the development of cardiovascular, cerebrovascular and metabolic co-morbidities in treated patients with acromegaly by Jayasena, C. N., Comninos, A. N., Clarke, H., Donaldson, M., Meeran, K., Dhillo, W. S.

“…Summary Background  Acromegaly is characterized by the hypersecretion of growth hormone (GH) and insulin‐like growth factor‐1 (IGF‐1). This leads to an…”
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Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem by Beale, KEL, Gardiner, JV, Bewick, GA, Hostomska, K, Patel, NA, Hussain, SS, Jayasena, CN, Ebling, FJP, Jethwa, PH, Prosser, HM, Lattanzi, R, Negri, L, Ghatei, MA, Bloom, SR, Dhillo, WS

“…Background and Purpose Prokineticin 2 (PK2) has recently been shown to acutely reduce food intake in rodents. We aimed to determine the CNS sites and receptors…”
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Twice-Daily Subcutaneous Injection of Kisspeptin-54 Does Not Abolish Menstrual Cyclicity in Healthy Female Volunteers by Jayasena, C. N, Comninos, A. N, Nijher, G. M. K, Abbara, A, De Silva, A, Veldhuis, J. D, Ratnasabapathy, R, Izzi-Engbeaya, C, Lim, A, Patel, D. A, Ghatei, M. A, Bloom, S. R, Dhillo, W. S

“…Background: Kisspeptin is a critical hypothalamic regulator of reproductive function. Chronic kisspeptin administration causes profound tachyphylaxis in male…”
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Kisspeptin‐54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms by Thompson, EL, Amber, V, Stamp, GWH, Patterson, M, Curtis, AE, Cooke, JH, Appleby, GF, Dhillo, WS, Ghatei, MA, Bloom, SR, Murphy, KG

“…Background and purpose:  The kisspeptins are critical regulators of reproduction and a therapeutic target for reproductive disease. Intracerebroventricular…”
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Free Cortisol Index Is Better Than Serum Total Cortisol in Determining Hypothalamic-Pituitary-Adrenal Status in Patients Undergoing Surgery by le Roux, C. W., Chapman, G. A., Kong, W. M., Dhillo, W. S., Jones, J., Alaghband-Zadeh, J.

“…Serum total cortisol has traditionally been used for the interpretation of tests of the hypothalamic-pituitary-adrenal axis. Approximately 80% of total…”
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The Effects of Neurokinin B upon Gonadotrophin Release in Male Rodents by Corander, M. P., Challis, B. G., Thompson, E. L., Jovanovic, Z., Loraine Tung, Y. C., Rimmington, D., Huhtaniemi, I. T., Murphy, K. G., Topaloglu, A. K., Yeo, G. S. H., O'Rahilly, S., Dhillo, W. S., Semple, R. K., Coll, A. P.

“…Growing evidence suggests the tachykinin neurokinin B (NKB) may modulate gonadotrophin secretion and play a role in sex‐steroid feedback within the…”
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Kisspeptin: A Novel Regulator of Reproductive Function by Dhillo, W. S.

“…Young Neuroendocrinologists Prize Reviews Michael Harbuz Young Investigator Prize Lecture The UK and international neuroendocrine community was deeply shocked…”
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The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal by FROST, G. S, BRYNES, A. E, DHILLO, W. S, BLOOM, S. R, MCBURNEY, M. I

“…To assess whether the addition of viscous fiber at an amount recommended by the US FDA to allow a 'low saturated fat, cholesterol, soluble fiber and coronary…”
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Serum phosphate predicts temporary hypocalcaemia following thyroidectomy by Sam, Amir H., Dhillo, W. S., Donaldson, M., Moolla, A., Meeran, K., Tolley, N. S., Palazzo, F. F.

“…Summary Background  Temporary hypocalcaemia occurs in up to 40% of patients following a total thyroidectomy. Serum calcium and parathyroid hormone (PTH)…”
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Comparison of the Dexamethasone-Suppressed Corticotropin-Releasing Hormone Test and Low-Dose Dexamethasone Suppression Test in the Diagnosis of Cushing’s Syndrome by Martin, N. M., Dhillo, W. S., Banerjee, A., Abdulali, A., Jayasena, C. N., Donaldson, M., Todd, J. F., Meeran, K.

“…Context: The low-dose dexamethasone suppression test (LDDST) is widely used in confirming a diagnosis of Cushing’s syndrome. CRH administration at the end of…”
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Testosterone therapy for sexual dysfunction in men with Type 2 diabetes: a systematic review and meta‐analysis of randomized controlled trials by Algeffari, M., Jayasena, C. N., MacKeith, P., Thapar, A., Dhillo, W. S., Oliver, N.

“…Aim To evaluate the effectiveness of testosterone therapy on a range of sexual function domains in men with Type 2 diabetes. Method Electronic databases were…”
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