Search Results - "Dhayalan, Balamurugan"

‘Smart’ insulin-delivery technologies and intrinsic glucose-responsive insulin analogues by Jarosinski, Mark A., Dhayalan, Balamurugan, Rege, Nischay, Chatterjee, Deepak, Weiss, Michael A.

“…Insulin replacement therapy for diabetes mellitus seeks to minimise excursions in blood glucose concentration above or below the therapeutic range (hyper- or…”
Get full text

Diabetes-Associated Mutations in Proinsulin Provide a “Molecular Rheostat” of Nascent Foldability by Dhayalan, Balamurugan, Weiss, Michael A.

“…Purpose of Review Diabetes mellitus (DM) due to toxic misfolding of proinsulin variants provides a monogenic model of endoplasmic reticulum (ER) stress. The…”
Get full text

Distinct states of proinsulin misfolding in MIDY by Haataja, Leena, Arunagiri, Anoop, Hassan, Anis, Regan, Kaitlin, Tsai, Billy, Dhayalan, Balamurugan, Weiss, Michael A., Liu, Ming, Arvan, Peter

“…A precondition for efficient proinsulin export from the endoplasmic reticulum (ER) is that proinsulin meets ER quality control folding requirements, including…”
Get full text

Se‐Glargine: Chemical Synthesis of a Basal Insulin Analogue Stabilized by an Internal Diselenide Bridge by Weil‐Ktorza, Orit, Dhayalan, Balamurugan, Chen, Yen‐Shan, Weiss, Michael A., Metanis, Norman

“…Insulin has long provided a model for studies of protein folding and stability, enabling enhanced treatment of diabetes mellitus via analogue design. We…”
Get full text

Structural Lessons From the Mutant Proinsulin Syndrome by Dhayalan, Balamurugan, Chatterjee, Deepak, Chen, Yen-Shan, Weiss, Michael A

“…Insight into folding mechanisms of proinsulin has been provided by analysis of dominant diabetes-associated mutations in the human insulin gene ( ). Such…”
Get full text

Reassessment of an Innovative Insulin Analogue Excludes Protracted Action yet Highlights the Distinction between External and Internal Diselenide Bridges by Dhayalan, Balamurugan, Chen, Yen‐Shan, Phillips, Nelson B., Swain, Mamuni, Rege, Nischay K., Mirsalehi, Ali, Jarosinski, Mark, Ismail‐Beigi, Faramarz, Metanis, Norman, Weiss, Michael A.

“…Long‐acting insulin analogues represent the most prescribed class of therapeutic proteins. An innovative design strategy was recently proposed: diselenide…”
Get full text

Structural principles of insulin formulation and analog design: A century of innovation by Jarosinski, Mark A., Dhayalan, Balamurugan, Chen, Yen-Shan, Chatterjee, Deepak, Varas, Nicolás, Weiss, Michael A.

“…The discovery of insulin in 1921 and its near-immediate clinical use initiated a century of innovation. Advances extended across a broad front, from the…”
Get full text

Scope and Limitations of Fmoc Chemistry SPPS‐Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin by Dhayalan, Balamurugan, Mandal, Kalyaneswar, Rege, Nischay, Weiss, Michael A., Eitel, Simon H., Meier, Thomas, Schoenleber, Ralph O., Kent, Stephen B. H.

“…We have systematically explored three approaches based on 9‐fluorenylmethoxycarbonyl (Fmoc) chemistry solid phase peptide synthesis (SPPS) for the total…”
Get full text

Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications by Yang, Yanwu, Glidden, Michael D, Dhayalan, Balamurugan, Zaykov, Alexander N, Chen, Yen-Shan, Wickramasinghe, Nalinda P, DiMarchi, Richard D, Weiss, Michael A

“…Toxic misfolding of proinsulin variants in β-cells defines a monogenic diabetes syndrome, designated (MIDY). In our first study (previous article in this…”
Get full text

Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation by Dhayalan, Balamurugan, Glidden, Michael D, Zaykov, Alexander N, Chen, Yen-Shan, Yang, Yanwu, Phillips, Nelson B, Ismail-Beigi, Faramarz, Jarosinski, Mark A, DiMarchi, Richard D, Weiss, Michael A

“…The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin's biosynthetic precursor. Also designated (MIDY),…”
Get full text

Refinement of Peptide Conformational Ensembles by 2D IR Spectroscopy: Application to Ala‒Ala‒Ala by Feng, Chi-Jui, Dhayalan, Balamurugan, Tokmakoff, Andrei

“…Characterizing ensembles of intrinsically disordered proteins is experimentally challenging because of the ill-conditioned nature of ensemble determination…”
Get full text

A Chemical Counterpart to the Resolution Step of Nature’s Intein-Mediated Protein Splicing by Dhayalan, Balamurugan, Kent, Stephen B. H., Fetter-Pruneda, Ingrid

“…In the course of an attempted total chemical synthesis of the ant insulin-like peptide-2 (ILP2) protein molecule, specific cleavage of a backbone peptide bond…”
Get full text

Can Helical Peptides Unwind One Turn at a Time? ‐ Controlled Conformational Transitions in α,β 2,3 ‐Hybrid Peptides by Balamurugan, Dhayalan, Muraleedharan, Kannoth M.

“…Abstract Unfolding of helical trans ‐β 2,3 ‐hybrid peptides with (α–β) n α composition, when executed by increasing solvent polarity or temperature, proceeded…”
Get full text

Can Helical Peptides Unwind One Turn at a Time? - Controlled Conformational Transitions in [alpha],[beta]2,3-Hybrid Peptides by Balamurugan, Dhayalan, Muraleedharan, Kannoth M

“…Unfolding of helical trans-[beta]2,3-hybrid peptides with ([alpha]-[beta])n[alpha] composition, when executed by increasing solvent polarity or temperature,…”
Get full text

Can Helical Peptides Unwind One Turn at a Time? - Controlled Conformational Transitions in α,β2,3-Hybrid Peptides by Balamurugan, Dhayalan, Muraleedharan, Kannoth M.

“…Unfolding of helical trans‐β2,3‐hybrid peptides with (α–β)nα composition, when executed by increasing solvent polarity or temperature, proceeded in a…”
Get full text

Can Helical Peptides Unwind One Turn at a Time? - Controlled Conformational Transitions in alpha , beta super(2,3)-Hybrid Peptides by Balamurugan, Dhayalan, Muraleedharan, Kannoth M

“…Unfolding of helical trans- beta super(2,3)-hybrid peptides with ( alpha - beta ) sub(n) alpha composition, when executed by increasing solvent polarity or…”
Get full text

Conformational Switching in Heterochiral α,β 2,3 ‐Hybrid Peptides in Response to Solvent Polarity by Balamurugan, Dhayalan, Muraleedharan, Kannoth M.

“…Abstract The ability of α,β 2,3 ‐hybrid peptides with a heterochiral backbone to exist in a helical, extended, or partially folded state depending on the…”
Get full text

Conformational Switching in Heterochiral α,β2,3-Hybrid Peptides in Response to Solvent Polarity by Balamurugan, Dhayalan, Muraleedharan, Kannoth M.

“…The ability of α,β2,3‐hybrid peptides with a heterochiral backbone to exist in a helical, extended, or partially folded state depending on the solvation…”
Get full text

Conformational Switching in Heterochiral [alpha],[beta]2,3-Hybrid Peptides in Response to Solvent Polarity by Balamurugan, Dhayalan, Muraleedharan, Kannoth M

“…The ability of [alpha],[beta]2,3-hybrid peptides with a heterochiral backbone to exist in a helical, extended, or partially folded state depending on the…”
Get full text

New Horizons: Next-Generation Insulin Analogues: Structural Principles and Clinical Goals by Jarosinski, Mark A, Chen, Yen-Shan, Varas, Nicolás, Dhayalan, Balamurugan, Chatterjee, Deepak, Weiss, Michael A

“…Design of "first-generation" insulin analogues over the past 3 decades has provided pharmaceutical formulations with tailored pharmacokinetic (PK) and…”
Get full text