Search Results - "Dhayagude, Usha"
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Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate
Published in Journal of medicinal chemistry (12-12-2019)“…The identification of a novel class of potent pan-genotypic NS5A inhibitors with good pharmacokinetic profile suitable for potential use in treating HCV…”
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Journal Article -
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Discovery of Potent, Selective, and State-Dependent Na V 1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure-Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides
Published in Journal of medicinal chemistry (11-06-2020)“…Voltage-gated sodium channel Na 1.7 is a genetically validated target for pain. Identification of Na 1.7 inhibitors with all of the desired properties to…”
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Journal Article