Search Results - "Dharmawardhane, Surangani"

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells by Baugher, Paige J, Krishnamoorthy, Lakshmi, Price, Janet E, Dharmawardhane, Surangani F

“…The metastatic progression of cancer is a direct result of the disregulation of numerous cellular signaling pathways, including those associated with adhesion,…”
Get full text

Estrogen and Resveratrol Regulate Rac and Cdc42 Signaling to the Actin Cytoskeleton of Metastatic Breast Cancer Cells by Azios, Nicolas G., Krishnamoorthy, Lakshmi, Harris, Micheleen, Cubano, Luis A., Cammer, Michael, Dharmawardhane, Surangani F.

“…Estrogen and structurally related molecules play critical roles in breast cancer. We reported that resveratrol (50 µM), an estrogen-like phytosterol from…”
Get full text

Combined Resveratrol, Quercetin, and Catechin Treatment Reduces Breast Tumor Growth in a Nude Mouse Model by Schlachterman, Alexander, Valle, Felix, Wall, Kristin M., Azios, Nicolas G., Castillo, Linette, Morell, Lymar, Washington, A. Valance, Cubano, Luis A., Dharmawardhane, Surangani F.

“…Grape polyphenols can act as antioxidants, antiangiogenics, and selective estrogen receptor (ER) modifiers and are therefore especially relevant for…”
Get full text

Abstract P2-01-05: MBQ-167 chemosensitizes triple-negative breast cancer cells to current chemotherapies and reduces paclitaxel-induced metastasis by Grafals-Ruiz, Nilmary, Cruz-Collazo, Ailed M., Torres-Sánchez, Anamaris, Dharmawardhane, Surangani

“…Triple-negative breast cancer (TNBC) is an aggressive and recurrent type of breast cancer that accounts for over 15% of new diagnoses yearly. Patients with…”
Get full text

Abstract 1678: Docetaxel induces Rac1 and Cdc42 Rho GTPase activation in prostate cancer cells by González, Andrea Paola López, González, Jessica Colón, Fuentes, María C. Santa María, Dharmawardhane, Surangani, Osterman, Carlos J. Diaz

“…Prostate cancer (PCa) is a major health burden that affects the quality of life of men worldwide. In the United States, PCa is the second leading cause of…”
Get full text

Adipocyte‐Breast Cancer Cell Interactions: Preventive Effects of Omega‐3 Fatty Acids by Aljawadi, Arwa, Ouertani, Meriam, Siriwardhana, Nalin, Scoggin, Shane, Gollahon, Lauren, Dharmawardhane, Surangani, Moustaid‐Moussa, Naima

“…Abstract only According to the American Cancer Society, breast cancer is the most common type of cancer and the second leading cause of death among women in…”
Get full text

Abstract 3076: Characterization of an improved derivative of the Rac/PAK inhibitor EHop-016 in breast cancer by Castillo-Pichardo, Linette, Humphries-Bickley, Tessa, Forrestier-Roman, Ingrid, Borrero-Garcia, Luis, Pagan Melendez, Fabiola, Hernandez, Eliud, Vlaar, Cornelis, Cubano, Luis A., Dharmawardhane, Surangani

“…The expression and activities of the Rho GTPases Rac and Cdc42, and their downstream effector P21-activated kinase (PAK), have been correlated with metastatic…”
Get full text

Abstract 3251: Characterization of a novel Rac inhibitor as an anti cancer metastasis compound by Ortiz, Brendaliz Montalvo, Ofarrill, Eliud Hernandez, Hernandez, Jonibeth, Vlaar, Cornelis, Flanagan, Surangani Dharmawardhane

“…The objective of this project is to design novel therapeutics targeting cancer metastasis, the most deadly aspect of epithelial cancers. Our previous studies…”
Get full text

The addition of a pregnenolone pendant group enhances the anticancer properties of titanocene dichloride in a mcf-7 xenograft model by Ramos, Gladiany, Loperena, Yaliz, Ortiz, Giovanni, Reyes, Fiorella, Szeto, Ada, Vera, Jose, Velez, Javier, Morales, Jessica, Morrero, Deborah, Castillo, Linnette, Dharmawardhane, Surangani, Melendez, Enrique, Washington, A Valance

“…Titanocene dichloride held great promise as a chemotherapeutic compound in pre-clinical studies. However, subsequent clinical trials revealed hepatoxicity and…”
Get full text

Novel inhibitors of Rac1 in metastatic breast cancer by Hernández, Eliud, De La Mota-Peynado, Alina, Dharmawardhane, Surangani, Vlaar, Cornelis P

“…Rho family GTPases are molecular switches that control signaling pathways regulating a myriad of cellular functions. Rac1, a Rho family member, plays a…”
Get full text

Abstract 623: Investigating potential off-target effects of the dual Rac and Cdc42 inhibitor MBQ-167 by Picon, Hector M., Maldonado, Maria Del Mar, Flanagan, Surangani F. Dharmawardhane

“…Metastasis is a major cause of death in epithelial cancers, largely because of a lack of effective treatments. The metastatic inhibitor MBQ-167 was developed…”
Get full text

Estrogen and Resveratrol Regulate Rac and Cdc42 Signaling to the Actin Cytoskeleton of Metastatic Breast Cancer Cells1 by Azios, Nicolas G, Krishnamoorthy, Lakshmi, Harris, Micheleen, Cubano, Luis A, Cammer, Michael, Dharmawardhane, Surangani F

“…Estrogen and structurally related molecules play critical roles in breast cancer. We reported that resveratrol (50 µM), an estrogen-like phytosterol from…”
Get full text

Abstract B094: The dual Rac/Cdc42 inhibitor MBQ-167 and derivatives as anticancer compounds by Castillo-PIchardo, Linette, Del Mar Maldonado, Maria, Ruiz-Calderon, Jean, Rodriguez-Orengo, Jose F., Hernandez, Eliud, Vlaar, Cornelis, Dharmawardhane Flanagan, Surangani F.

“…Metastatic disease lacks effective treatments, and remains the primary cause of mortality from epithelial cancers. The Rho family GTPases Rac and Cdc42 and…”
Get full text

Abstract A155: The Rac and PAK inhibitor EHop-016 inhibits mammary tumor growth and metastasis in a nude mouse model by Castillo-Pichardo, Linette, Humphries-Bickley, Tessa, Hernandez, Eliud, de la Parra, Columba, Cubano, Luis, Vlaar, Cornelis, Dharmawardhane Flanagan, Surangani F.

“…The Rho GTPase Rac is a central regulator of cancer cell migration/invasion that has been implicated with cancer metastasis. Therefore, we designed and…”
Get full text

Combined Resveratrol, Quercetin, and Catechin Treatment Reduces Breast Tumor Growth in a Nude Mouse Model1 by Schlachterman, Alexander, Valle, Felix, Wall, Kristin M, Azios, Nicolas G, Castillo, Linette, Morell, Lymar, Washington, A. Valance, Cubano, Luis A, Dharmawardhane, Surangani F

“…Grape polyphenols can act as antioxidants, antiangiogenics, and selective estrogen receptor (ER) modifiers and are therefore especially relevant for…”
Get full text