Search Results - "Dharia, Neekesh V."

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells by Meyers, Robin M, Bryan, Jordan G, McFarland, James M, Weir, Barbara A, Sizemore, Ann E, Xu, Han, Dharia, Neekesh V, Montgomery, Phillip G, Cowley, Glenn S, Pantel, Sasha, Goodale, Amy, Lee, Yenarae, Ali, Levi D, Jiang, Guozhi, Lubonja, Rakela, Harrington, William F, Strickland, Matthew, Wu, Ting, Hawes, Derek C, Zhivich, Victor A, Wyatt, Meghan R, Kalani, Zohra, Chang, Jaime J, Okamoto, Michael, Stegmaier, Kimberly, Golub, Todd R, Boehm, Jesse S, Vazquez, Francisca, Root, David E, Hahn, William C, Tsherniak, Aviad

“…CERES is a new computational method to estimate gene-dependency levels from CRISPR–Cas9 essentiality screens while accounting for copy number effects and…”
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Spiroindolones, a Potent Compound Class for the Treatment of Malaria by Rottmann, Matthias, McNamara, Case, Yeung, Bryan K.S, Lee, Marcus C.S, Zou, Bin, Russell, Bruce, Seitz, Patrick, Plouffe, David M, Dharia, Neekesh V, Tan, Jocelyn, Cohen, Steven B, Spencer, Kathryn R, González-Páez, Gonzalo E, Lakshminarayana, Suresh B, Goh, Anne, Suwanarusk, Rossarin, Jegla, Timothy, Schmitt, Esther K, Beck, Hans-Peter, Brun, Reto, Nosten, Francois, Renia, Laurent, Dartois, Veronique, Keller, Thomas H, Fidock, David A, Winzeler, Elizabeth A, Diagana, Thierry T

“…Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments…”
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Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families by Bopp, Selina E R, Manary, Micah J, Bright, A Taylor, Johnston, Geoffrey L, Dharia, Neekesh V, Luna, Fabio L, McCormack, Susan, Plouffe, David, McNamara, Case W, Walker, John R, Fidock, David A, Denchi, Eros Lazzerini, Winzeler, Elizabeth A

“…Malaria parasites elude eradication attempts both within the human host and across nations. At the individual level, parasites evade the host immune responses…”
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Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models by Ng, Samuel Y., Yoshida, Noriaki, Christie, Amanda L., Ghandi, Mahmoud, Dharia, Neekesh V., Dempster, Joshua, Murakami, Mark, Shigemori, Kay, Morrow, Sara N., Van Scoyk, Alexandria, Cordero, Nicolas A., Stevenson, Kristen E., Puligandla, Maneka, Haas, Brian, Lo, Christopher, Meyers, Robin, Gao, Galen, Cherniack, Andrew, Louissaint, Abner, Nardi, Valentina, Thorner, Aaron R., Long, Henry, Qiu, Xintao, Morgan, Elizabeth A., Dorfman, David M., Fiore, Danilo, Jang, Julie, Epstein, Alan L., Dogan, Ahmet, Zhang, Yanming, Horwitz, Steven M., Jacobsen, Eric D., Santiago, Solimar, Ren, Jian-Guo, Guerlavais, Vincent, Annis, D. Allen, Aivado, Manuel, Saleh, Mansoor N., Mehta, Amitkumar, Tsherniak, Aviad, Root, David, Vazquez, Francisca, Hahn, William C., Inghirami, Giorgio, Aster, Jon C., Weinstock, David M., Koch, Raphael

“…T- and NK-cell lymphomas (TCL) are a heterogenous group of lymphoid malignancies with poor prognosis. In contrast to B-cell and myeloid malignancies, there are…”
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An In Vivo CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML by Lin, Shan, Larrue, Clément, Scheidegger, Nastassja K, Seong, Bo Kyung A, Dharia, Neekesh V, Kuljanin, Miljan, Wechsler, Caroline S, Kugener, Guillaume, Robichaud, Amanda L, Conway, Amy Saur, Mashaka, Thelma, Mouche, Sarah, Adane, Biniam, Ryan, Jeremy A, Mancias, Joseph D, Younger, Scott T, Piccioni, Federica, Lee, Lynn H, Wunderlich, Mark, Letai, Anthony, Tamburini, Jérôme, Stegmaier, Kimberly

“…CRISPR-Cas9-based genetic screens have successfully identified cell type-dependent liabilities in cancer, including acute myeloid leukemia (AML), a devastating…”
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Esterase mutation is a mechanism of resistance to antimalarial compounds by Istvan, Eva S., Mallari, Jeremy P., Corey, Victoria C., Dharia, Neekesh V., Marshall, Garland R., Winzeler, Elizabeth A., Goldberg, Daniel E.

“…Pepstatin is a potent peptidyl inhibitor of various malarial aspartic proteases, and also has parasiticidal activity. Activity of pepstatin against cultured…”
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Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-Pressured Plasmodium falciparum Parasites by EASTMAN, Richard T, DHARIA, Neekesh V, WINZELER, Elizabeth A, FIDOCK, David A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors by Howard, Thomas P, Arnoff, Taylor E, Song, Melinda R, Giacomelli, Andrew O, Wang, Xiaofeng, Hong, Andrew L, Dharia, Neekesh V, Wang, Su, Vazquez, Francisca, Pham, Minh-Tam, Morgan, Ann M, Wachter, Franziska, Bird, Gregory H, Kugener, Guillaume, Oberlick, Elaine M, Rees, Matthew G, Tiv, Hong L, Hwang, Justin H, Walsh, Katherine H, Cook, April, Krill-Burger, John M, Tsherniak, Aviad, Gokhale, Prafulla C, Park, Peter J, Stegmaier, Kimberly, Walensky, Loren D, Hahn, William C, Roberts, Charles W M

“…Malignant rhabdoid tumors (MRT) are highly aggressive pediatric cancers that respond poorly to current therapies. In this study, we screened several MRT cell…”
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Validation of isoleucine utilization targets in Plasmodium falciparum by Istvan, Eva S., Dharia, Neekesh V., Bopp, Selina E., Gluzman, Ilya, Winzeler, Elizabeth A., Goldberg, Daniel E., Wellems, Thomas E.

“…Intraerythrocytic malaria parasites can obtain nearly their entire amino acid requirement by degrading host cell hemoglobin. The sole exception is isoleucine,…”
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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma by Bandopadhayay, Pratiti, Piccioni, Federica, O’Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth M., Buchan, Graham, Qian, Kenin, Gionet, Gabrielle, Girard, Emily, Coxon, Margo, Rees, Matthew G., Brenan, Lisa, Dubois, Frank, Shapira, Ofer, Greenwald, Noah F., Pages, Melanie, Balboni Iniguez, Amanda, Paolella, Brenton R., Meng, Alice, Sinai, Claire, Roti, Giovanni, Dharia, Neekesh V., Creech, Amanda, Tanenbaum, Benjamin, Khadka, Prasidda, Tracy, Adam, Tiv, Hong L., Hong, Andrew L., Coy, Shannon, Rashid, Rumana, Lin, Jia-Ren, Cowley, Glenn S., Lam, Fred C., Goodale, Amy, Lee, Yenarae, Schoolcraft, Kathleen, Vazquez, Francisca, Hahn, William C., Tsherniak, Aviad, Bradner, James E., Yaffe, Michael B., Milde, Till, Pfister, Stefan M., Qi, Jun, Schenone, Monica, Carr, Steven A., Ligon, Keith L., Kieran, Mark W., Santagata, Sandro, Olson, James M., Gokhale, Prafulla C., Jaffe, Jacob D., Root, David E., Stegmaier, Kimberly, Johannessen, Cory M., Beroukhim, Rameen

“…BET-bromodomain inhibition (BETi) has shown pre-clinical promise for MYC-amplified medulloblastoma. However, the mechanisms for its action, and ultimately for…”
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Comparative proteomics reveals a diagnostic signature for pulmonary head‐and‐neck cancer metastasis by Bohnenberger, Hanibal, Kaderali, Lars, Ströbel, Philipp, Yepes, Diego, Plessmann, Uwe, Dharia, Neekesh V, Yao, Sha, Heydt, Carina, Merkelbach‐Bruse, Sabine, Emmert, Alexander, Hoffmann, Jonatan, Bodemeyer, Julius, Reuter‐Jessen, Kirsten, Lois, Anna‐Maria, Dröge, Leif Hendrik, Baumeister, Philipp, Walz, Christoph, Biggemann, Lorenz, Walter, Roland, Häupl, Björn, Comoglio, Federico, Pan, Kuan‐Ting, Scheich, Sebastian, Lenz, Christof, Küffer, Stefan, Bremmer, Felix, Kitz, Julia, Sitte, Maren, Beißbarth, Tim, Hinterthaner, Marc, Sebastian, Martin, Lotz, Joachim, Schildhaus, Hans‐Ulrich, Wolff, Hendrik, Danner, Bernhard C, Brandts, Christian, Büttner, Reinhard, Canis, Martin, Stegmaier, Kimberly, Serve, Hubert, Urlaub, Henning, Oellerich, Thomas

“…Patients with head‐and‐neck cancer can develop both lung metastasis and primary lung cancer during the course of their disease. Despite the clinical importance…”
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Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q by Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Yang, Annan, Kalekar, Radha L., Krill-Burger, John M., Dharia, Neekesh V., Kugener, Guillaume, Kalfon, Jérémie, Yuan, Chen, Dumont, Nancy, Gonzalez, Alfredo, Abdusamad, Mai, Li, Yvonne Y., Spurr, Liam F., Wu, Westley W., Durbin, Adam D., Wolpin, Brian M., Piccioni, Federica, Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.

“…Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new…”
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Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer by Guerra, Rachel M., Bird, Gregory H., Harvey, Edward P., Dharia, Neekesh V., Korshavn, Kyle J., Prew, Michelle S., Stegmaier, Kimberly, Walensky, Loren D.

“…Cancer cells overexpress a diversity of anti-apoptotic BCL-2 family proteins, such as BCL-2, MCL-1, and BFL-1/A1, to enforce cellular immortality. Thus,…”
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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors by Oberlick, Elaine M., Rees, Matthew G., Seashore-Ludlow, Brinton, Vazquez, Francisca, Nelson, Geoffrey M., Dharia, Neekesh V., Weir, Barbara A., Tsherniak, Aviad, Ghandi, Mahmoud, Krill-Burger, John M., Meyers, Robin M., Wang, Xiaofeng, Montgomery, Phil, Root, David E., Bieber, Jake M., Radko, Sandi, Cheah, Jaime H., Hon, C. Suk-Yee, Shamji, Alykhan F., Clemons, Paul A., Park, Peter J., Dyer, Michael A., Golub, Todd R., Stegmaier, Kimberly, Hahn, William C., Stewart, Elizabeth A., Schreiber, Stuart L., Roberts, Charles W.M.

“…Cancer is often seen as a disease of mutations and chromosomal abnormalities. However, some cancers, including pediatric rhabdoid tumors (RTs), lack recurrent…”
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Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes by Dharia, Neekesh V., Bright, A. Taylor, Westenberger, Scott J., Barnes, S. Whitney, Batalov, Serge, Kuhen, Kelli, Borboa, Rachel, Federe, Glenn C., McClean, Colleen M., Vinetz, Joseph M., Neyra, Victor, Llanos-Cuentas, Alejandro, Barnwell, John W., Walker, John R., Winzeler, Elizabeth A., James, Anthony A.

“…Plasmodium vivax causes 25-40% of malaria cases worldwide, yet research on this human malaria parasite has been neglected. Nevertheless, the recent publication…”
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Transcriptional Plasticity Drives Leukemia Immune Escape by Eagle, Kenneth, Harada, Taku, Kalfon, Jérémie, Perez, Monika W, Heshmati, Yaser, Ewers, Jazmin, Koren, Jošt Vrabič, Dempster, Joshua M, Kugener, Guillaume, Paralkar, Vikram R, Lin, Charles Y, Dharia, Neekesh V, Stegmaier, Kimberly, Orkin, Stuart H, Pimkin, Maxim

“…Relapse of acute myeloid leukemia (AML) after allogeneic bone marrow transplantation has been linked to immune evasion due to reduced expression of major…”
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A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor by Nam, Tae-gyu, McNamara, Case W, Bopp, Selina, Dharia, Neekesh V, Meister, Stephan, Bonamy, Ghislain M. C, Plouffe, David M, Kato, Nobutaka, McCormack, Susan, Bursulaya, Badry, Ke, Hangjun, Vaidya, Akhil B, Schultz, Peter G, Winzeler, Elizabeth A

“…Decoquinate has single-digit nanomolar activity against in vitro blood stage Plasmodium falciparum parasites, the causative agent of human malaria. In vitro…”
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Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q by Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Yang, Annan, Kalekar, Radha L., Krill-Burger, John M., Dharia, Neekesh V., Kugener, Guillaume, Kalfon, Jérémie, Yuan, Chen, Dumont, Nancy, Gonzalez, Alfredo, Abdusamad, Mai, Li, Yvonne Y., Spurr, Liam F., Wu, Westley W., Durbin, Adam D., Wolpin, Brian M., Piccioni, Federica, Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.

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A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito by Westenberger, Scott J, McClean, Colleen M, Chattopadhyay, Rana, Dharia, Neekesh V, Carlton, Jane M, Barnwell, John W, Collins, William E, Hoffman, Stephen L, Zhou, Yingyao, Vinetz, Joseph M, Winzeler, Elizabeth A

“…Up to 40% of the world's population is at risk for Plasmodium vivax malaria, a disease that imposes a major public health and economic burden on endemic…”
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Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry by Durbin, Adam D., Zimmerman, Mark W., Dharia, Neekesh V., Abraham, Brian J., Iniguez, Amanda Balboni, Weichert-Leahey, Nina, He, Shuning, Krill-Burger, John M., Root, David E., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Golub, Todd R., Young, Richard A., Look, A. Thomas, Stegmaier, Kimberly

“…Childhood high-risk neuroblastomas with MYCN gene amplification are difficult to treat effectively 1 . This has focused attention on tumor-specific gene…”
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