Search Results - "Dhareshwar, S S"

Amorphous Solid Dispersions or Prodrugs: Complementary Strategies to Increase Drug Absorption by Rumondor, Alfred C F, Dhareshwar, Sundeep S, Kesisoglou, Filippos

“…Maximizing oral bioavailability of drug candidates represents a challenge in the pharmaceutical industry. In recent years, there has been an increase in the…”
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Establishing the Safe Space via Physiologically Based Biopharmaceutics Modeling. Case Study: Fevipiprant/QAW039 by Kourentas, Alexandros, Gajewska, Monika, Lin, Wen, Dhareshwar, Sundeep S., Steib-Lauer, Caroline, Kulkarni, Swarupa, Hirsch, Stefan, Heimbach, Tycho, Mueller-Zsigmondy, Martin

“…Physiologically based pharmacokinetic and absorption modeling has increasingly been implemented for biopharmaceutics applications to define the safe space for…”
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A Rapid 3-Day Excipient Screening Methodology and its Application in Identifying Chemical Stabilizers for Solid Formulations with Mixed Mechanisms of Degradation by Matharu, Amol S., Dhareshwar, Sundeep S., Cao, Yu (Jade)

“…This study outlines a practical approach for assessing chemical instability by heating the drug-excipient binary mixtures or multi-excipient formulations at…”
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Formulation Intervention to Overcome Decreased Kinetic Solubility of a Low Tg Amorphous Drug by Bordawekar, Mangesh S., Pudipeddi, Madhu, Ruegger, Colleen E., Dhareshwar, Sundeep S.

“…This technical note investigated the loss of dissolution rate during accelerated stability studies with a dry blend capsule formulation containing an amorphous…”
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Formulation Intervention to Overcome Decreased Kinetic Solubility of a Low T g Amorphous Drug by Bordawekar, Mangesh S, Pudipeddi, Madhu, Ruegger, Colleen E, Dhareshwar, Sundeep S

“…This technical note investigated the loss of dissolution rate during accelerated stability studies with a dry blend capsule formulation containing an amorphous…”
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Dispersive Raman Spectroscopy for Quantifying Amorphous Drug Content in Intact Tablets by Wabuyele, Busolo Wa, Sotthivirat, Sutthilug, Zhou, George X, Ash, Jason, Dhareshwar, Sundeep S

“…Process-induced inadvertent phase change of an active pharmaceutical ingredient in a drug product could impact chemical stability, physical stability, shelf…”
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Your prodrug releases formaldehyde: should you be concerned? No by Dhareshwar, Sundeep S, Stella, Valentino J

“…The title of this commentary contains a frequently asked question whenever someone presents or proposes a prodrug strategy that releases formaldehyde as a…”
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Commercial scale transfer of a twin-screw melt granulation process for high drug load fevipiprant tablets by Vicente Martin, Claudia, Stocker, Stephan, Bautista, Manel, Rogue, Vincent, Steib-Lauer, Caroline, Häcker, Hans-Georg, Spickermann, Dirk, Hirsch, Stefan, Dhareshwar, Sundeep S.

“…This work summarizes select methodology of twin-screw melt granulation (TSMG) and process analytical technology that were used in the successful scaling-up and…”
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A novel prodrug strategy for beta-dicarbonyl carbon acids: syntheses and evaluation of the physicochemical characteristics of C-phosphoryloxymethyl (POM) and phosphoryloxymethyloxymethyl (POMOM) prodrug derivatives by Dhareshwar, Sundeep S, Stella, Valentino J

“…The C-phosphoryloxymethyl (POM) and phosphoryloxymethyloxymethyl (POMOM) prodrugs resulting from derivatization at the reactive alpha-carbon of beta-dicarbonyl…”
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Breakdown kinetics of C-hydroxymethyl beta-dicarbonyl derivatives of carbon acids: implications in the bioconversion rate of C-phosphoryloxymethyl prodrugs of carbon acids by Dhareshwar, Sundeep S, Stella, Valentino J

“…The kinetics of conversion of C-hydroxymethyl derivatives of pharmaceutically relevant beta-dicarbonyl carbon acids of two series, pyrazolidin-3,5-diones and…”
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Recombinant DNA and the pediatrician by Dhareshwar, S S

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Normomorphic sialidosis in two female adults with severe neurologic disease and without sialyl oligosacchariduria by HARZER, K, CANTZ, M, SEWELL, A. C, DHARESHWAR, S. S, ROGGENDORF, W, HECKL, R. W, SCHOFER, O, THUMLER, R, PEIFFER, J, SCHLOTE, W

“…Two female patients of German origin, aged 38 and 21 years, with myoclonus epilepsy and cerebellar ataxia, but without dysmorphic signs and dementia, were…”
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Clinical, biochemical & cytogenetic studies in mental retardation by Ambani, L M, Patel, Z M, Dhareshwar, S S, Krishnamurthy, D S, Moghe, M S, Mulye, V R, Gokarn, V V, Peter, J J, Shah, L P, Merchant, S M

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Cataracts in Down syndrome by Dhareshwar, S S, Gokarn, V V, Ambani, L M

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Monozygotic twinning and sirenomelia by Raghavan, K R, Ambani, L M, Ratnaparki, S K, Dhareshwar, S S, Khare, D A, Badbade, J N

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Chondrodysplasia punctata by Dhareshwar, S S, Mehta, K P, Patkar, S L, Patel, Z M, Ambani, L M

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GM2-gangliosidosis, Type 2 (Sandhoff disease) by Varadkar, A M, Mahale, S D, Suchak, R H, Patel, Z M, Dhareshwar, S S, Ambani, L M

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Inborn errors of metabolism in acutely sick children by Dhareshwar, S S, Ambani, L M, Suchak, R H, Danthi, V

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Phosphoryloxymethyl/(oxymethyl) prodrugs of β-dicarbonyl carbon acid drugs by Dhareshwar, Sundeep S

“…The overall objective of this dissertation is to report the syntheses, and evaluation of phosphoryloxymethyl (POM) and phosphoryloxymethyl oxymethyl (POMOM)…”
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Phosphoryloxymethyl/(oxymethyl) prodrugs of beta-dicarbonyl carbon acid drugs by Dhareshwar, Sundeep S

“…The overall objective of this dissertation is to report the syntheses, and evaluation of phosphoryloxymethyl (POM) and phosphoryloxymethyl oxymethyl (POMOM)…”
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