Search Results - "Dharavath, Ravinder"
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Microwave-assisted synthesis, molecular docking studies of 1,2,3-triazole-based carbazole derivatives as antimicrobial, antioxidant and anticancer agents
Published in RSC advances (19-12-2022)“…Herein, a new series of N -substituted 1,2,3-triazolylmethyl indole derivatives 4(a-u) was synthesized by rationally incorporating a pharmacophoric active…”
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2
Naringenin Ameliorates Chronic Sleep Deprivation‐Induced Pain via Sirtuin1 Inhibition
Published in Neurochemical research (01-05-2021)“…Growing experimental evidences have suggested the reciprocal correlation between sleep deprivation and pain. Inflammation and oxidative stress are among the…”
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3
Neurobehavioral alterations in a mouse model of chronic partial sleep deprivation
Published in Metabolic brain disease (01-08-2021)“…The night shift paradigm induces a state of chronic partial sleep deprivation (CPSD) and enhances the vulnerability to neuronal dysfunction. However, the…”
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4
Microwave-assisted synthesis and in vitro antiproliferative activity of some novel 1,2,3-triazole-based pyrazole aldehydes and their benzimidazole derivatives
Published in Medicinal chemistry research (01-04-2020)“…A series of new 3-(5-methyl-1-aryl-1 H -1,2,3-triazol-4-yl)-1-phenyl-1 H -pyrazole-4-carbaldehydes 4(a–g) and their benzimidazole derivatives 6 ( a – g) were…”
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5
Microwave-assisted synthesis of some new 1,2,3-triazole derivatives and their antimicrobial activity
Published in Journal of chemical sciences (Bangalore, India) (01-12-2020)“…A series of new 1,2,3-triazole derivatives were designed and synthesised through Cu(I) catalysed 1,3-dipolar cycloaddition of alkynes and organic azides namely…”
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6
Co-abuse of alprazolam augments the hepato-renal toxic effects of methylphenidate
Published in Indian journal of pharmacology (01-05-2020)“…OBJECTIVE: Methylphenidate (MPH) is a first-line treatment option for attention-deficit hyperactive disorder and narcolepsy. MPH is one of the most abused…”
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7
Microwave Assisted Synthesis of Flavonoid Based 1,2,3-Triazole and Isoxazole Derivatives, Their Antibacterial, Antioxidant, and Anticancer Activities
Published in Russian journal of general chemistry (01-04-2022)“…New flavonoid based 1,2,3-triazole and isoxazole derivatives have been synthesized under microwave irradiation and conventional heating methods. Structures of…”
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8
Microwave-Assisted Synthesis of Substituted 2-(2H-Chromen-3-yl)-5-phenyl-1H-imidazole Based Coumarin Derivatives and Their Antimicrobial Activity
Published in Russian journal of general chemistry (01-04-2021)“…A number of new imidazole-coumarin structures have been synthesised under conventional heating and MW irradiation methods. Structures of all synthesized…”
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9
Microwave-assisted synthesis and evaluation of their antiproliferative, antimicrobial, activities and DNA Binding studies of (3-Methyl-7H-furo[2,3-f]chromen-2-yl)(aryl)methanones
Published in Medicinal chemistry research (01-06-2022)“…A series of (3-methyl-7 H -furo[2,3-]chromen-2-yl)(aryl)methanones were quickly prepared through easily accessible, short-span progress microwave irradiation…”
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10
One-pot three-component condensation for the synthesis of 2,4,6-triarylpyridines and evaluation of their antimicrobial activity
Published in Journal of chemical sciences (Bangalore, India) (2021)“…A new series of 2,4,6-triarylpyridines are synthesised through one-pot three-component condensation of triazole pyrazolyl aldehydes and acetophenones with…”
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11
Microwave-assisted synthesis of (6-((1-(4-aminophenyl)-1H-1,2,3-triazol-4-yl)methoxy)substituted benzofuran-2-yl)(phenyl)methanones, evaluation of in vitro anticancer, antimicrobial activities and molecular docking on COVID-19
Published in Results in Chemistry (01-01-2022)“…[Display omitted] •Conventional and sustainable microwave-assisted synthesis.•13 new intermediates and 15 target 4-aminophenyl-1H 1,2,3-traizole based…”
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12
High fat-low protein diet induces metabolic alterations and cognitive dysfunction in female rats
Published in Metabolic brain disease (01-12-2019)“…Approximately one-third of the world population is suffering from MetS, and the same is expected to rise in the years to come. Worldwide, most of the staple…”
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13
Mucin secretory action of capsaicin prevents high fat diet-induced gut barrier dysfunction in C57BL/6 mice colon
Published in Biomedicine & pharmacotherapy (01-01-2022)“…The gut barrier – including tight junction proteins (TJPs) and mucus layers, is the first line of defense against physical, chemical or pathogenic incursions…”
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14
GABAergic signaling in alcohol use disorder and withdrawal: pathological involvement and therapeutic potential
Published in Frontiers in neural circuits (20-10-2023)“…Alcohol is one of the most widely used substances. Alcohol use accounts for 5.1% of the global disease burden, contributes substantially to societal and…”
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15
Alpha-Lipoic Acid Ameliorates Doxorubicin-Induced Cognitive Impairments by Modulating Neuroinflammation and Oxidative Stress via NRF-2/HO-1 Signaling Pathway in the Rat Hippocampus
Published in Neurochemical research (01-08-2023)“…Chemotherapy-induced cognitive impairment (CICI) is a common complication associated with the use of chemotherapeutics. Doxorubicin (DOX) is a reactive oxygen…”
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16
Nrf2 Signaling Pathway: a Potential Therapeutic Target in Combating Oxidative Stress and Neurotoxicity in Chemotherapy-Induced Cognitive Impairment
Published in Molecular neurobiology (01-02-2024)“…Chemotherapy-induced cognitive impairment (CICI) is one of the major adverse effects of antineoplastic drugs, which decrease the quality of life in cancer…”
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17
Time-response studies on development of cognitive deficits in an experimental model of insulin resistance
Published in Clinical nutrition (Edinburgh, Scotland) (01-06-2019)“…Alzheimer's disease is suggested to be primarily metabolic, mainly characterized by brain insulin resistance. Chronic fructose feeding results in hippocampal…”
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Cu@CTF as an efficient heterogeneous catalyst in click reaction between azide and alkyne towards disubstituted triazoles
Published in Journal of molecular structure (15-07-2023)“…•Copper embedded covalent triazine framework (Cu@CTF) as a heterogeneous catalyst for alkyne azide cycloaddition reaction.•Cu@CTF gives pure products with high…”
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19
Saroglitazar, a novel dual PPAR-α/γ agonist, reverses high fat-low protein diet-induced metabolic and cognitive aberrations in C57BL/6J male mice
Published in Life sciences (1973) (15-04-2021)“…Insulin resistance (IR) has become one of the major causative factors for the pathogenesis of various metabolic and neurometabolic diseases. The sedentary…”
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20
Differential effects of alprazolam against methylphenidate-induced neurobehavioral alterations
Published in Physiology & behavior (01-08-2020)“…•Co-administration of ALZ and MPH, increased oxidative stress and inflammation in cortex and hippocampus.•ALZ reduced moderately the MPH-induced anxiety and…”
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