Search Results - "Dhar, K L"

Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents by Bhat, B.A., Dhar, K.L., Puri, S.C., Saxena, A.K., Shanmugavel, M., Qazi, G.N.

“…[Display omitted] A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a…”
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A rational approach for the design and synthesis of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles as a new class of potential non-purine xanthine oxidase inhibitors by Nepali, Kunal, Singh, Gurinderdeep, Turan, Anil, Agarwal, Amit, Sapra, Sameer, Kumar, Raj, Banerjee, Uttam C., Verma, Prabhakar K., Satti, Naresh K., Gupta, Manish K., Suri, Om P., Dhar, K.L.

“…Xanthine oxidase is a complex molybdoflavoprotein that catalyses the hydroxylation of xanthine to uric acid. Fifty three analogues of…”
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Synthesis and biological evaluation of arylidene analogues of Meldrum’s acid as a new class of antimalarial and antioxidant agents by Sandhu, Harmeet S., Sapra, Sameer, Gupta, Mukesh, Nepali, Kunal, Gautam, Raju, Yadav, Sunil, Kumar, Raj, Jachak, Sanjay M., Chugh, Manoj, Gupta, Manish K., Suri, Om P., Dhar, K.L.

“…A series of arylidene analogues of Meldrum’s acid were synthesized and evaluated for in vitro antimalarial and antioxidant activities for the first time. The…”
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Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids by Nepali, Kunal, Sharma, Sahil, Sharma, Manmohan, Bedi, P.M.S., Dhar, K.L.

“…A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single molecule are basically designed to interact with multiple targets or…”
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Development of colon specific microspheres of flurbiprofen for inflammatory bowel disease by Sareen, Rashmi, Jain, Nitin, Dhar, K L

“…In the present investigation chitosan microspheres loaded with flurbiprofen (FLB) were prepared by oil/oil emulsification method for colon specific drug…”
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Development and Optimization of Osmotically Controlled Asymmetric Membrane Capsules for Delivery of Solid Dispersion of Lycopene by Dhar, K. L., Mahindroo, Neeraj, Sareen, Rashmi, Jain, Nitin

“…The aim of the present investigation is to develop and statistically optimize the osmotically controlled asymmetric membrane capsules of solid dispersion of…”
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Curcumin-Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic effects by Sareen, Rashmi, Jain, Nitin, Dhar, K. L.

“…Objective: The aim of present investigation was to prepare Curcumin-Zn(II) complex in a view to enhance solubility, stability and pharmacodynamic effect in…”
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Immunomodulatory potential of a bioactive fraction from the leaves of Phyllostachys bambusoides (bamboo) in BALB/c mice by Kumar, Sunil, Sharma, Gaurav, Sidiq, Tabasum, Khajuria, Anamika, Jain, Mahendra, Bhagwat, Deepak, Dhar, K L

“…In order to evaluate the role of ethyl acetate fraction (PB-EtAC) obtained from the Phyllostachys bambusoides leaves in the modulation of immune responses,…”
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Curcumin Loaded Microsponges for Colon Targeting in Inflammatory Bowel Disease : Fabrication, Optimization, and In Vitro and Pharmacodynamic Evaluation by Sareen, Rashmi, Nath, Kavita, Jain, Nitin, Dhar, K. L.

“…The present study was aimed to develop and optimize the microsponges of curcumin for colon specific drug delivery in a view to bypass the upper…”
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pH triggered delivery of curcumin from Eudragit-coated chitosan microspheres for inflammatory bowel disease: characterization and pharmacodynamic evaluation by Sareen, Rashmi, Jain, Nitin, Rajkumari, Ananya, Dhar, K L

“…This investigation deals with the development and evaluation (in vitro and in vivo) of pH triggered Eudragit-coated chitosan microspheres of curcumin (CUR) for…”
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Synthesis and bronchodilator activity of new quinazolin derivative by Zabeer, A., Bhagat, A., Gupta, O.P., Singh, G.D., Youssouf, M.S., Dhar, K.L., Suri, O.P., Suri, K.A., Satti, N.K., Gupta, B.D., Qazi, G.N.

“…Taking lead from a naturally occurring quinazolin vasicine, a number of compounds were developed and evaluated for bronchodilator and anti-allergic activities…”
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Isolation of isoflavones from Iris kashmiriana Baker as potential anti proliferative agents targeting NF-kappaB by Alam, Afroze, Jaiswal, Varun, Akhtar, Sohail, Jayashree, B.S., Dhar, K.L.

“…Cancer is possibly one of the most devastating and complex disease and therefore involves chemotherapy as one of the frontline strategies in its therapy…”
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Isolation, characterization and biological evaluation of datura lactones as potential immunomodulators by Bhat, B.A., Dhar, K.L., Puri, S.C., Qurishi, M.A., Khajuria, A., Gupta, Amit, Qazi, G.N.

“…Phytochemical investigation of Datura quercifolia (Solanaceae) plant yielded a new datura lactone, 1β,5α,12α-trihydroxy-6α,7α,24α,25α-diepoxy-20 S,22 R…”
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Synthesis and Biological Evaluation of Chalcones having Heterosubstituent(s) by Sweety, Kumar, S, Nepali, K, Sapra, S, Suri, O P, Dhar, K L, Sarma, G S, Saxena, A K

“…Chalcones and their synthetic analogues appear to have the same binding site of tubuline as phenstatin, combretastatin steganacin and podophylotoxin and are…”
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Separation of 9-Methoxycamptothecin and Camptothecin from Nothapodytes foetida by Semipreparative HPLC by Puri, S.C., Handa, G., Bhat, B.A., Gupta, V.K., Amna, T., Verma, N., Anand, R., Dhar, K.L., Qazi, G.N.

“…The present work describes the isolation of camptothecin and 9-methoxycamptothecin from the aerial parts of Nothapodytes foetida by semipreparative…”
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Structure-activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome P450 activities by KOUL, S, KOUL, J. L, TANEJA, S. C, DHAR, K. L, JAMWAL, D. S, SINGH, K, REEN, R. K, SINGH, J

“…Inhibitors of drug metabolism have important implications in pharmaco-toxicology and agriculture. We have reported earlier that piperine, a major alkaloid of…”
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Bioefficacy of crude extracts of Aglaia species (Meliaceae) and some active fractions against lepidopteran larvae by Koul, O., Shankar, J. S., Mehta, N., Taneja, S. C., Tripathi, A. K., Dhar, K. L.

“…Foliar and twig extracts of three species of Aglaia were screened for larval growth inhibiting and antifeedant effects against the polyphagous lepidopteran…”
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Synthesis and biological evaluation of naphthalene, furan and pyrrole based chalcones as cytotoxic and antimicrobial agents by Budhiraja, Abhishek, Kadian, Kanika, Kaur, Mandeep, Aggarwal, Vikas, Garg, Atul, Sapra, Sameer, Nepali, Kunal, Suri, O. P., Dhar, K. L.

“…Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. These…”
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Koelpinin- A, B and C — three triterpenoids from Koelpinia linearis by Koul, Summon, Razdan, T.K., Andotra, C.S., Kalla, A.K., Koul, S., Taneja, S.C., Dhar, K.L.

“…Three new triterpenoids, designated as koelpinin - A, B and C and characterised as 28- nor-lup-12,17-dien-3β,16α-diol,3β-acetoxy-28- nor-lup-12,17-dien-16α-ol…”
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Chemical Investigation and Anti-Inflammatory Activity of Vitex negundo Seeds by Chawla, A. S, Sharma, A. K, Handa, S. S, Dhar, K. L

“…The CHCl3 extract of the defatted seeds of Vitex negundo exhibited anti-inflammatory activity and yielded four triterpenoids: 3 beta-acetoxyolean-12-en-27-oic…”
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