Search Results - "Dhandapany, Perundurai S"

Heterogeneous Distribution of Genetic Mutations in Myosin Binding Protein-C Paralogs by Desai, Darshini A., Rao, Vinay J., Jegga, Anil G., Dhandapany, Perundurai S., Sadayappan, Sakthivel

“…Myosin binding protein-C (MyBP-C) is a sarcomeric protein which regulates the force of contraction in striated muscles. Mutations in the MYBPC family of genes,…”
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Sleep fragmentation induces heart failure in a hypertrophic cardiomyopathy mouse model by altering redox metabolism by Bose, Karthikeyan, Agrawal, Radhika, Sairam, Thiagarajan, Mil, Jessenya, Butler, Matthew P., Dhandapany, Perundurai S.

“…Sleep fragmentation (SF) disrupts normal biological rhythms and has major impacts on cardiovascular health; however, it has never been shown to be a risk…”
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A novel arginine to tryptophan (R144W) mutation in troponin T (cTnT) gene in an indian multigenerational family with dilated cardiomyopathy (FDCM) by Rani, Deepa Selvi, Dhandapany, Perundurai S, Nallari, Pratibha, Narasimhan, Calambur, Thangaraj, Kumarasamy

“…Cardiomyopathy is a major cause of heart failure and sudden cardiac death; several mutations in sarcomeric protein genes have been associated with this…”
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Novel Mutations in β-MYH7 Gene in Indian Patients With Dilated Cardiomyopathy by Rani, Deepa Selvi, Vijaya Kumar, Archana, Nallari, Pratibha, Sampathkumar, Katakam, Dhandapany, Perundurai S., Narasimhan, Calambur, Rathinavel, Andiappan, Thangaraj, Kumarasamy

“…Heart failure is a hallmark of severe hypertrophic cardiomyopathy and dilated cardiomyopathy (DCM). Several mutations in the β-MYH7 gene lead to hypertrophic…”
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Association of Sleep Duration with Stroke in Diabetic Patients: Analysis of the National Health Interview Survey by Akinseye, Oluwaseun A., MD, Ojike, Nwakile I., MD, Akinseye, Leah I., MD, Dhandapany, Perundurai S., PhD, Pandi-Perumal, Seithikurippu R., MSc

“…Background Habitual sleep duration is increasingly being recognized as an important risk factor for stroke. We sought to describe the association between sleep…”
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Targeted genome-wide enrichment of functional regions by Senapathy, Periannan, Bhasi, Ashwini, Mattox, Jeffrey, Dhandapany, Perundurai S, Sadayappan, Sakthivel

“…Only a small fraction of large genomes such as that of the human contains the functional regions such as the exons, promoters, and polyA sites. A platform…”
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A field-based quantitative analysis of sublethal effects of air pollution on pollinators by Thimmegowda, Geetha G., Mullen, Susan, Sottilare, Katie, Sharma, Ankit, Mohanta, Saptashi Soham, Brockmann, Axel, Dhandapany, Perundurai S., Olsson, Shannon B.

“…While the impact of air pollution on human health is well studied, mechanistic impacts of air pollution on wild systems, including those providing essential…”
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Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes by Dhandapany, Perundurai S, Fabris, Frank, Tonk, Rahul, Illaste, Ardo, Karakikes, Ioannis, Sorourian, Mehran, Sheng, Jipo, Hajjar, Roger J, Tartaglia, Marco, Sobie, Eric A, Lebeche, Djamel, Gelb, Bruce D

“…Abstract RAS activation is implicated in physiologic and pathologic cardiac hypertrophy. Cross-talk between the Ras and calcineurin pathways, the latter also…”
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Cardiomyocyte orientation recovery at micrometer scale reveals long-axis fiber continuum in heart walls by Dileep, Drisya, Syed, Tabish A, Sloan, Tyler Fw, Dhandapany, Perundurai S, Siddiqi, Kaleem, Sirajuddin, Minhajuddin

“…Coordinated cardiomyocyte contraction drives the mammalian heart to beat and circulate blood. No consensus model of cardiomyocyte geometrical arrangement…”
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REPLY TO NEGRI ET AL: Air pollution and health impacts on bees: Signs of causation by Thimmegowda, Geetha G., Brockmann, Axel, Dhandapany, Perundurai S., Olsson, Shannon B.

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Cardiac isoform of alpha-2 macroglobulin—A new biomarker for myocardial infarcted diabetic patients by Annapoorani, Ponnambalam, Dhandapany, Perundurai S., Sadayappan, Sakthivel, Ramasamy, Subbiah, Rathinavel, Andiappan, Selvam, Govindan Sadasivam

“…Cardiac isoform of alpha-2 macroglobulin [cardiac α2M] has been shown to be an early marker in cardiac hypertrophy and left ventricular mass in humans. We,…”
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Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy by Jain, Pratul Kumar, Jayappa, Shashank, Sairam, Thiagarajan, Mittal, Anupam, Paul, Sayan, Rao, Vinay J, Chittora, Harshil, Kashyap, Deepak K, Palakodeti, Dasaradhi, Thangaraj, Kumarasamy, Shenthar, Jayaprakash, Koranchery, Rakesh, Rajendran, Ranjith, Alireza, Haghighi, Mohanan, Kurukkanparampil Sreedharan, Rathinavel, Andiappan, Dhandapany, Perundurai S

“…Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease with preserved or increased ejection fraction in the absence of secondary causes. Mutations…”
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Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse Model of Systemic Sclerosis by Rana, Isha, Kataria, Sunny, Tan, Tuan Lin, Hajam, Edries Yousaf, Kashyap, Deepak Kumar, Saha, Dyuti, Ajnabi, Johan, Paul, Sayan, Jayappa, Shashank, Ananthan, Akhil S.H.P., Kumar, Pankaj, Zaarour, Rania F., Haarshaadri, J., Kansagara, Gaurav, Rizvi, Abrar, Zirmire, Ravindra K., Badarinath, Krithika, Khedkar, Sneha Uday, Chandra, Yogesh, Samuel, Rekha, George, Renu, Danda, Debashish, Jacob, Paul Mazhuvanchary, Dey, Rakesh, Dhandapany, Perundurai S., He, You-Wen, Varga, John, Varghese, Shyni, Jamora, Colin

“…Systemic sclerosis is a fibrotic disease that initiates in the skin and progresses to internal organs, leading to a poor prognosis. Unraveling the etiology of…”
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A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia by Thangaraj, Kumarasamy, Dhandapany, Perundurai S, Sadayappan, Sakthivel, Xue, Yali, Powell, Gareth T, Rani, Deepa Selvi, Nallari, Prathiba, Rai, Taranjit Singh, Khullar, Madhu, Soares, Pedro, Bahl, Ajay, Tharkan, Jagan Mohan, Vaideeswar, Pradeep, Rathinavel, Andiappan, Narasimhan, Calambur, Ayapati, Dharma Rakshak, Ayub, Qasim, Mehdi, S Qasim, Oppenheimer, Stephen, Richards, Martin B, Price, Alkes L, Patterson, Nick, Reich, David, Singh, Lalji, Tyler-Smith, Chris

“…Heart failure is a leading cause of mortality in South Asians. However, its genetic etiology remains largely unknown. Cardiomyopathies due to sarcomeric…”
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Generation of a new human induced pluripotent stem cell (hiPSC) line from a South Asian Indian with a MYBPC3Δ25bp variant by Chimata, Prasanth, Kashyap, Deepak K, Sairam, Thiagarajan, Ganesh, Akshayaa, Thangaraj, Kumarasamy, Purushottam, Meera, Viswanath, Biju, Jain, Sanjeev, Dhandapany, Perundurai S

“…Myosin binding protein C3 (MYBPC3) is a thick filament contractile protein that interacts with myosin, titin and actin and regulates cardiac muscle…”
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Mitochondrial genome variations in idiopathic dilated cardiomyopathy by Govindaraj, Periyasamy, Rani, Bindu, Sundaravadivel, Pandarisamy, Vanniarajan, Ayyasamy, Indumathi, K P, Khan, Nahid Akthar, Dhandapany, Perundurai S, Rani, Deepa Selvi, Tamang, Rakesh, Bahl, Ajay, Narasimhan, Calambur, Rakshak, Dharma, Rathinavel, Andiappan, Premkumar, Kumpati, Khullar, Madhu, Thangaraj, Kumarasamy

“…Idiopathic dilated cardiomyopathy (DCM) is a structural heart disease with strong genetic background. The aim of this study was to assess the role of…”
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Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia by Mulero-Navarro, Sonia, Sevilla, Ana, Roman, Angel C., Lee, Dung-Fang, D’Souza, Sunita L., Pardo, Sherly, Riess, Ilan, Su, Jie, Cohen, Ninette, Schaniel, Christoph, Rodriguez, Nelson A., Baccarini, Alessia, Brown, Brian D., Cavé, Hélène, Caye, Aurélie, Strullu, Marion, Yalcin, Safak, Park, Christopher Y., Dhandapany, Perundurai S., Yongchao, Ge, Edelmann, Lisa, Bahieg, Sawsan, Raynal, Patrick, Flex, Elisabetta, Tartaglia, Marco, Moore, Kateri A., Lemischka, Ihor R., Gelb, Bruce D.

“…Somatic PTPN11 mutations cause juvenile myelomonocytic leukemia (JMML). Germline PTPN11 defects cause Noonan syndrome (NS), and specific inherited mutations…”
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RAF1 mutations in childhood-onset dilated cardiomyopathy by Dhandapany, Perundurai S, Razzaque, Md Abdur, Muthusami, Uthiralingam, Kunnoth, Sreejith, Edwards, Jonathan J, Mulero-Navarro, Sonia, Riess, Ilan, Pardo, Sherly, Sheng, Jipo, Rani, Deepa Selvi, Rani, Bindu, Govindaraj, Periyasamy, Flex, Elisabetta, Yokota, Tomohiro, Furutani, Michiko, Nishizawa, Tsutomu, Nakanishi, Toshio, Robbins, Jeffrey, Limongelli, Giuseppe, Hajjar, Roger J, Lebeche, Djamel, Bahl, Ajay, Khullar, Madhu, Rathinavel, Andiappan, Sadler, Kirsten C, Tartaglia, Marco, Matsuoka, Rumiko, Thangaraj, Kumarasamy, Gelb, Bruce D

“…Bruce Gelb and colleagues identify rare RAF1 mutations in individuals with childhood-onset dilated cardiomyopathy in three cohorts from South India, North…”
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Evolutionary conserved networks of human height identify multiple Mendelian causes of short stature by Hauer, Nadine N, Popp, Bernt, Taher, Leila, Vogl, Carina, Dhandapany, Perundurai S, Büttner, Christian, Uebe, Steffen, Sticht, Heinrich, Ferrazzi, Fulvia, Ekici, Arif B, De Luca, Alessandro, Klinger, Patrizia, Kraus, Cornelia, Zweier, Christiane, Wiesener, Antje, Jamra, Rami Abou, Kunstmann, Erdmute, Rauch, Anita, Wieczorek, Dagmar, Jung, Anna-Marie, Rohrer, Tilman R, Zenker, Martin, Doerr, Helmuth-Guenther, Reis, André, Thiel, Christian T

“…Height is a heritable and highly heterogeneous trait. Short stature affects 3% of the population and in most cases is genetic in origin. After excluding known…”
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Dominant negative Ras attenuates pathological ventricular remodeling in pressure overload cardiac hypertrophy by Ramos-Kuri, Manuel, Rapti, Kleopatra, Mehel, Hind, Zhang, Shihong, Dhandapany, Perundurai S., Liang, Lifan, García-Carrancá, Alejandro, Bobe, Regis, Fischmeister, Rodolphe, Adnot, Serge, Lebeche, Djamel, Hajjar, Roger J., Lipskaia, Larissa, Chemaly, Elie R.

“…The importance of the oncogene Ras in cardiac hypertrophy is well appreciated. The hypertrophic effects of the constitutively active mutant Ras-Val12 are…”
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