Search Results - "Dhammika Nanayakkara, N.P."

Enantiomeric resolution of (±)-licarin A by high-performance liquid-chromatography using a chiral stationary phase by Pereira, Ana Carolina, Magalhães, Lizandra G., Januário, Ana Helena, Pauletti, Patrícia M., Cunha, Wilson Roberto, Bastos, Jairo Kenupp, Nanayakkara, Dhammika N.P., e Silva, Márcio Luis A.

“…(±)-Licarin A ( 1), a neolignan obtained by the oxidative coupling reaction of isoeugenol, had in this study its enantiomers resolved. A novel, quick and…”
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Alkylresorcinol Synthases Expressed in Sorghum bicolor Root Hairs Play an Essential Role in the Biosynthesis of the Allelopathic Benzoquinone Sorgoleone by Cook, Daniel, Rimando, Agnes M, Clemente, Thomas E, Schröder, Joachim, Dayan, Franck E, Nanayakkara, N.P. Dhammika, Pan, Zhiqiang, Noonan, Brice P, Fishbein, Mark, Abe, Ikuro, Duke, Stephen O, Baerson, Scott R

“…Sorghum bicolor is considered to be an allelopathic crop species, producing phytotoxins such as the lipid benzoquinone sorgoleone, which likely accounts for…”
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Enantioselective pharmacokinetics of primaquine in healthy human volunteers by Tekwani, Babu L, Avula, Bharathi, Sahu, Rajnish, Chaurasiya, Narayan D, Khan, Shabana I, Jain, Surendra, Fasinu, Pius S, Herath, H M T Bandara, Stanford, Donald, Nanayakkara, N P Dhammika, McChesney, James D, Yates, Travis W, ElSohly, Mahmoud A, Khan, Ikhlas A, Walker, Larry A

“…Primaquine (PQ), a racemic drug, is the only treatment available for radical cure of relapsing Plasmodium vivax malaria and blocking transmission of P…”
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Anti-inflammatory and antinociceptive effects of Baccharis dracunculifolia DC (Asteraceae) in different experimental models by dos Santos, Diogo A., Fukui, Murilo de J., Dhammika Nanayakkara, N.P., Khan, Shabana I., Sousa, João Paulo B., Bastos, Jairo K., Andrade, Sérgio F., da Silva Filho, Ademar A., Quintão, Nara L.M.

“…This study demonstrated that Baccharis dracunculifolia extract (BdE), a native plant to southern Brazil and the major source of green propolis, had…”
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In vitro anti-allergic activity of the fungal metabolite pyridovericin by de Souza Santos, Marcela, Jonis Andrioli, Willian, Freire de Morais Del Lama, Maria Perpétua, Kenupp Bastos, Jairo, Nanayakkara, N.P. Dhammika, Zumstein Georgetto Naal, Rose Mary

“…Mast cells play a critical role during the development of an allergic response. Upon activation by an antigen and IgE, via FcεRI receptors, mast cells release…”
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Antioxidant and Cytotoxic Effects of Crude Extract, Fractions and 4-Nerolidylcathecol from Aerial Parts of Pothomorphe umbellata L. (Piperaceae) by Perazzo, Fabio Ferreira, Maistro, Edson L., Carlos Tavares Carvalho, José, Nanayakkara, Dhammika N. P., Rosa, Paulo C. P., Bagatela, Bianca S., Lopes, Andrey P., Bastos, Jairo Kennup

“…The crude ethanolic extract from aerial parts of Pothomorphe umbellata L. (Piperaceae) and fractions obtained by partitions sequentially among water-methanol,…”
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Anti-inflammatory and analgesic properties of water–ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts by Perazzo, Fabio F., Souza, Gustavo H.B., Lopes, Walter, Cardoso, Luis G.V., Carvalho, Jose C.T., Nanayakkara, N.P. Dhammika, Bastos, Jairo K.

“…Anti-inflammatory and analgesic activities as well as the median lethal dose (LD 50) of water–ethanolic extract (PHE) of the aerial parts of Pothomorphe…”
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Quantitative analysis of primaquine and its metabolites in human urine using liquid chromatography coupled with tandem mass spectrometry by Khan, Washim, Wang, Yan-Hong, Dhammika Nanayakkara, N.P., Bandara Herath, H.M.T., Chaurasiya, Narayan D., Tekwani, Babu L., ElSohly, Mahmoud A., McChesney, James D., Khan, Ikhlas A., Walker, Larry A.

“…•UPLC-MS/MS method for simultaneous quantification of primaquine and its metabolites in human urine.•Simple sample preparation with no apparent matrix…”
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Quantitative determination of primaquine-5,6-ortho-quinone and carboxyprimaquine-5,6-ortho-quinone in human erythrocytes by UHPLC-MS/MS by Khan, Washim, Wang, Yan-Hong, Nanayakkara, N.P. Dhammika, Herath, H.M.T. Bandara, Catchings, Zachara, Khan, Shabana, Fasinu, Pius S., ElSohly, Mahmoud A., McChesney, James D., Khan, Ikhlas A., Chaurasiya, Narayan D., Tekwani, Babu L., Walker, Larry A.

“…•The quantification of POQ and CPOQ in erythrocytes by LC-MS/MS was developed.•The developed method was sensitive, precise, and accurate with a run time of…”
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(±)-Licarin A and its semi-synthetic derivatives: In vitro and in silico evaluation of trypanocidal and schistosomicidal activities by Meleti, Vanderlisa Rita, Esperandim, Viviane Rodrigues, Flauzino, Luzio Gabriel Bocalon, Prizantelli, Anna Helena, Paula, Lucas Antônio de Lima, Magalhães, Lizandra Guidi, Cunha, Wilson Roberto, Laurentiz, Rosângela da Silva, Pissurno, Ana Paula da Rocha, Nanayakkara, N.P. Dhammika, Pereira, Ana Carolina, Bastos, Jairo Kenupp, Parreira, Renato Luis Tâme, Orenha, Renato Pereira, e Silva, Márcio Luis Andrade

“…•This paper reports the synthesis of (±)-licarin A.•Three semi-synthetic derivatives of (±)-licarin A also were prepared.•The compounds were evaluated against…”
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Role of Natural Antioxidants from Functional Foods in Neurodegenerative and Metabolic Disorders by Carvalho, José C. T., Fernandes, Caio P., Daleprane, Julio B., Alves, Maria S., Stien, Didier, Dhammika Nanayakkara, N. P.

“…[...]it is noteworthy that the antioxidants play a crucial role in both food systems and in the human body to reduce oxidative processes and, consequently,…”
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Mycoleptones A–C and Polyketides from the Endophyte Mycoleptodiscus indicus by Andrioli, Willian J, Conti, Raphael, Araújo, Magali J, Zanasi, Riccardo, Cavalcanti, Bruno C, Manfrim, Viviane, Toledo, Juliano S, Tedesco, Daniele, de Moraes, Manoel O, Pessoa, Cláudia, Cruz, Angela K, Bertucci, Carlo, Sabino, José, Nanayakkara, Dhammika N. P, Pupo, Mônica. T, Bastos, Jairo K

“…Three new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a…”
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Furofuran lignans display schistosomicidal and trypanocidal activities by e Silva, Márcio Luis Andrade, Esperandim, Viviane Rodrigues, Ferreira, Daniele da Silva, Magalhães, Lizandra Guidi, Lima, Thais Coelho, Cunha, Wilson Roberto, Nanayakkara, Dhammika N.P., Pereira, Ana Carolina, Bastos, Jairo Kenupp

“…This paper describes schistosomicidal, trypanocidal, and leishmanicidal activities of dehydrodiferulic acid dilactone 1 and dehydrodisinapic acid dilactone 2…”
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Antiprotozoal and Antimicrobial Compounds from the Plant Pathogen Septoria pistaciarum by Kumarihamy, Mallika, Khan, Shabana I, Jacob, Melissa, Tekwani, Babu L, Duke, Stephen O, Ferreira, Daneel, Nanayakkara, N.P. Dhammika

“…Four new 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids, 17-hydroxy-N-(O-methyl)septoriamycin A (1), 17-acetoxy-N-(O-methyl)septoriamycin A (2),…”
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New secondary metabolites from bioactive extracts of the fungus Armillaria tabescens by Herath, H.M.T. Bandara, Jacob, Melissa, Wilson, A. Dan, Abbas, Hamed K., Nanayakkara, N.P. Dhammika

“…Ethyl acetate extracts of Armillaria tabescens (strain JNB-OZ344) showed significant fungistatic and bacteristatic activities against several major human…”
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Inhibition of human monoamine oxidase A and B by 5-phenoxy 8-aminoquinoline analogs by Chaurasiya, Narayan D., Ganesan, Shobana, Nanayakkara, N.P. Dhammika, Dias, Luiza R.S., Walker, Larry A., Tekwani, Babu L.

“…8-Aminoquinolines (8-AQs) are important class of anti-infective therapeutics. 5-Phenoxy 8-aminoquinoline analogs have shown improved metabolic stability…”
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Methemoglobinemia Caused by 8-Aminoquinoline Drugs: DFT Calculations Suggest an Analogy to H4B’s Role in Nitric Oxide Synthase by Liu, Haining, Walker, Larry A, Nanayakkara, N.P. Dhammika, Doerksen, Robert J

“…We suggest a possible mechanism of how 8-aminoquinolines (8-AQ’s) cause hemotoxicity by oxidizing hemoglobin to methemoglobin. In our DFT calculations, we…”
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A Functional Genomics Investigation of Allelochemical Biosynthesis in Sorghum bicolor Root Hairs by Baerson, Scott R., Dayan, Franck E., Rimando, Agnes M., Nanayakkara, N. P. Dhammika, Liu, Chang-Jun, Schröder, Joachim, Fishbein, Mark, Pan, Zhiqiang, Kagan, Isabelle A., Pratt, Lee H., Cordonnier-Pratt, Marie-Michèle, Duke, Stephen O.

“…Sorghum is considered to be one of the more allelopathic crop species, producing phytotoxins such as the potent benzoquinone sorgoleone…”
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Bioactive 1,4-Dihydroxy-5-phenyl-2-pyridinone Alkaloids from Septoria pistaciarum by Kumarihamy, Mallika, Fronczek, Frank R, Ferreira, Daneel, Jacob, Melissa, Khan, Shabana I, Nanayakkara, N.P. Dhammika

“…Four new 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids (1−4) were isolated from an EtOAc extract of a culture medium of Septoria pistaciarum. The structures of…”
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Evaluation of antimicrobial and antimalarial activities of crude extract, fractions and 4-nerolidylcathecol from the aerial parts of Piper umbellata L. (Piperaceae) by Bagatela, Bianca Souza, Lopes, Andrey Pereira, Fonseca, Fernando Luiz Affonso, Andreo, Márcio Adriano, Nanayakkara, Dhammika N.P., Bastos, Jairo Kenupp, Perazzo, Fábio Ferreira

“…Presently, natural products, such as Piper umbellata L. (Piperaceae), have been evaluated as sources of antimicrobial agents with efficacies against…”
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