Search Results - "Dhamija, Sonam"

Beclin 1 Phosphorylation - at the Center of Autophagy Regulation by Menon, Manoj B, Dhamija, Sonam

“…Autophagy is a tightly regulated catabolic process wherein cells under stress sequester cytosolic constituents like damaged proteins and organelles in…”
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The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation by Tiedje, Christopher, Ronkina, Natalia, Tehrani, Mohammad, Dhamija, Sonam, Laass, Kathrin, Holtmann, Helmut, Kotlyarov, Alexey, Gaestel, Matthias

“…TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU-rich element (ARE) in the TNF mRNA…”
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Exonized Alu repeats in the 3'UTR of a CYP20A1_Alu-LT transcript act as a miRNA sponge by Singhal, Khushboo, Dhamija, Sonam, Mukerji, Mitali

“…Alu repeats have gained huge importance in the creation and modification of regulatory networks. We previously reported a unique isoform of human CYP20A1 i.e…”
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Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns by Ghosh, Avantika, Riester, Marisa, Pal, Jagriti, Lainde, Kadri-Ann, Tangermann, Carla, Wanninger, Angela, Dueren, Ursula K., Dhamija, Sonam, Diederichs, Sven

“…Nonstop extension mutations, a.k.a. stop-lost or stop-loss mutations, convert a stop codon into a sense codon resulting in translation into the 3’ untranslated…”
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A pan-cancer analysis reveals nonstop extension mutations causing SMAD4 tumour suppressor degradation by Dhamija, Sonam, Yang, Chul Min, Seiler, Jeanette, Myacheva, Ksenia, Caudron-Herger, Maiwen, Wieland, Angela, Abdelkarim, Mahmoud, Sharma, Yogita, Riester, Marisa, Groß, Matthias, Maurer, Jochen, Diederichs, Sven

“…Nonstop or stop-loss mutations convert a stop into a sense codon, resulting in translation into the 3′ untranslated region as a nonstop extension mutation to…”
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Systematic analysis of migration factors by MigExpress identifies essential cell migration control genes in non‐small cell lung cancer by Pal, Jagriti, Becker, Andrea C., Dhamija, Sonam, Seiler, Jeanette, Abdelkarim, Mahmoud, Sharma, Yogita, Behr, Jürgen, Meng, Chen, Ludwig, Christina, Kuster, Bernhard, Diederichs, Sven

“…Cell migration is an essential process in health and in disease, including cancer metastasis. A comprehensive inventory of migration factors is nonetheless…”
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Functional Analysis of KSRP Interaction with the AU-Rich Element of Interleukin-8 and Identification of Inflammatory mRNA Targets by Winzen, Reinhard, Thakur, Basant Kumar, Dittrich-Breiholz, Oliver, Shah, Meera, Redich, Natalie, Dhamija, Sonam, Kracht, Michael, Holtmann, Helmut

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis by Dhamija, Sonam, Diederichs, Sven

“…Metastasis is a multistep process that involves the dissemination of cells from the primary tumor and colonization of distant secondary organs. Epithelial…”
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LINC00261 and the Adjacent Gene FOXA2 Are Epithelial Markers and Are Suppressed during Lung Cancer Tumorigenesis and Progression by Dhamija, Sonam, Becker, Andrea C, Sharma, Yogita, Myacheva, Ksenia, Seiler, Jeanette, Diederichs, Sven

“…Lung cancer continues to be the leading cause of cancer-related deaths worldwide, with little improvement in patient survival rates in the past decade. Long…”
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Lyz2 -Cre-Mediated Genetic Deletion of Septin7 Reveals a Role of Septins in Macrophage Cytokinesis and Kras -Driven Tumorigenesis by Menon, Manoj B, Yakovleva, Tatiana, Ronkina, Natalia, Suwandi, Abdulhadi, Odak, Ivan, Dhamija, Sonam, Sandrock, Inga, Hansmann, Florian, Baumgärtner, Wolfgang, Förster, Reinhold, Kotlyarov, Alexey, Gaestel, Matthias

“…By crossing -floxed mice with -Cre mice carrying the Cre recombinase inserted in the Lysozyme-M ( ) gene locus we aimed the specific deletion of septin7 in…”
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Non-coding transcript variants of protein-coding genes - what are they good for? by Dhamija, Sonam, Menon, Manoj B.

“…The total number of protein-coding genes in the human genome is not significantly higher than those in much simpler eukaryotes, despite a general increase in…”
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The Slowing Rate of CpG Depletion in SARS-CoV-2 Genomes Is Consistent with Adaptations to the Human Host by Kumar, Akhil, Goyal, Nishank, Saranathan, Nandhini, Dhamija, Sonam, Saraswat, Saurabh, Menon, Manoj B, Vivekanandan, Perumal

“…Abstract Depletion of CpG dinucleotides in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genomes has been linked to virus evolution,…”
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Stem cell factor‐mediated upregulation of SIRT1 protects melanin‐deprived keratinocytes against UV‐induced DNA damage in individuals with vitiligo by Brahmbhatt, Hemang D., Chowdhary, Manish, Gupta, Rohit, Priya, Anshu, Kundu, Akta, Singh, Praveen, Dhamija, Sonam, Gupta, Aayush, Singh, Archana

“…Despite the loss of melanocytes, individuals with vitiligo have a significantly lower risk of developing skin malignancies compared to ethnicity‐matched…”
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The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research by Menon, Manoj B, Dhamija, Sonam, Kotlyarov, Alexey, Gaestel, Matthias

“…In addition to its established role in inflammation, the stress-activated p38 MAP kinase pathway plays major roles in the regulation of cell cycle, senescence,…”
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Interleukin-1 Activates Synthesis of Interleukin-6 by Interfering with a KH-type Splicing Regulatory Protein (KSRP)-dependent Translational Silencing Mechanism by Dhamija, Sonam, Kuehne, Nancy, Winzen, Reinhard, Doerrie, Anneke, Dittrich-Breiholz, Oliver, Thakur, Basant Kumar, Kracht, Michael, Holtmann, Helmut

“…Post-transcriptional mechanisms play an important role in the control of inflammatory gene expression. The heterogeneous nuclear ribonucleoprotein K homology…”
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IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IκBζ mRNA by Dhamija, Sonam, Doerrie, Anneke, Winzen, Reinhard, Dittrich-Breiholz, Oliver, Taghipour, Azadeh, Kuehne, Nancy, Kracht, Michael, Holtmann, Helmut

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IL-1-induced Post-transcriptional Mechanisms Target Overlapping Translational Silencing and Destabilizing Elements in IκBζ mRNA[S] by Dhamija, Sonam, Doerrie, Anneke, Winzen, Reinhard, Dittrich-Breiholz, Oliver, Taghipour, Azadeh, Kuehne, Nancy, Kracht, Michael, Holtmann, Helmut

“…The inflammatory cytokine IL-1 induces profound changes in gene expression. This is contributed in part by activating translation of a distinct set of mRNAs,…”
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Interleukin-17 (IL-17) and IL-1 Activate Translation of Overlapping Sets of mRNAs, Including That of the Negative Regulator of Inflammation, MCPIP1 by Dhamija, Sonam, Winzen, Reinhard, Doerrie, Anneke, Behrens, Gesine, Kuehne, Nancy, Schauerte, Celina, Neumann, Elena, Dittrich-Breiholz, Oliver, Kracht, Michael, Holtmann, Helmut

“…Changes in gene expression during inflammation are in part caused by post-transcriptional mechanisms. A transcriptome-wide screen for changes in ribosome…”
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The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation by Vučićević, Dubravka, Gehre, Maja, Dhamija, Sonam, Friis-Hansen, Lennart, Meierhofer, David, Sauer, Sascha, Ørom, Ulf Andersson

“…Long non-coding RNAs are important regulators of gene expression and signaling pathways. The expression of long ncRNAs is dysregulated in cancer and other…”
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IL-1-induced Post-transcriptional Mechanisms Target Overlapping Translational Silencing and Destabilizing Elements in IB mRNA by Dhamija, Sonam, Doerrie, Anneke, Winzen, Reinhard, Dittrich-Breiholz, Oliver, Taghipour, Azadeh, Kuehne, Nancy, Kracht, Michael, Holtmann, Helmut

“…The inflammatory cytokine IL-1 induces profound changes in gene expression. This is contributed in part by activating translation of a distinct set of mRNAs,…”
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