Search Results - "Dhakshinamoorthy, S"

Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury by Leonard, Martin O, Kieran, Niamh E, Howell, Katherine, Burne, Melissa J, Varadarajan, Raghu, Dhakshinamoorthy, Saravanakumar, Porter, Alan G, O'Farrelly, Cliona, Rabb, Hamid, Taylor, Cormac T

“…Tissue reoxygenation following hypoxia is associated with ischemia-reperfusion injury (IRI) and may signal the development of ischemic preconditioning, an…”
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Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene by Dhakshinamoorthy, S, Jaiswal, A K

“…Antioxidant response element (ARE) and nuclear transcription factor Nrf2 are known to regulate expression and coordinated induction of NQO1 and other…”
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Bach1 Competes with Nrf2 Leading to Negative Regulation of the Antioxidant Response Element (ARE)-mediated NAD(P)H:Quinone Oxidoreductase 1 Gene Expression and Induction in Response to Antioxidants by Dhakshinamoorthy, Saravanakumar, Jain, Abhinav K., Bloom, David A., Jaiswal, Anil K.

“…The antioxidant response element (ARE) and Nrf2 are known to regulate the expression and coordinated induction of genes encoding detoxifying enzymes including…”
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Nitric Oxide-induced Transcriptional Up-regulation of Protective Genes by Nrf2 via the Antioxidant Response Element Counteracts Apoptosis of Neuroblastoma Cells by Dhakshinamoorthy, Saravanakumar, Porter, Alan G

“…Nitric oxide (NO) is a signaling molecule that in excess causes cell death. Here we report a mechanism of NO-induced transcriptional up-regulation of genes…”
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POS-023 SECONDARY THROMBOTIC MICROANGIOPATHY – CLINICAL PROFILE AND OUTCOME by KAMALAKANNAN, G., Shaji, S., Solomon, D., Ravindran, K., Kannan Srinivasan, B., Paulpandian, V., Aruyerchelvan, C., Arumugam, V., Selvanathan, D., Alavudeen Sulthan, S., Dhakshinamoorthy, S., Natarajan, G.

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Small Maf (MafG and MafK) Proteins Negatively Regulate Antioxidant Response Element-mediated Expression and Antioxidant Induction of the NAD(P)H:Quinone Oxidoreductase1 Gene by Dhakshinamoorthy, Saravanakumar, Jaiswal, Anil K.

“…The antioxidant response element (ARE) is known to regulate expression and induction of NQO1, GST Ya, and other detoxifying enzyme genes in response to…”
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AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells by Urbano, Alexander, Lakshmanan, Umayal, Choo, Poh Heok, Kwan, Jair Chau, Ng, Poh Yong, Guo, Ke, Dhakshinamoorthy, Saravanakumar, Porter, Alan

“…Apoptosis‐inducing factor (AIF) exhibits reactive oxygen species (ROS)‐generating NADH oxidase activity of unknown significance, which is dispensable for…”
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c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction by DHAKSHINAMOORTHY, Saravanakumar, JAISWAL, Anil K

“…Anti-oxidant response element (ARE) and nuclear factors including Nrf2 and small Maf (MafG and MafK) proteins are known to regulate expression and induction of…”
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Protein/DNA arrays identify nitric oxide-regulated cis-element and trans-factor activities some of which govern neuroblastoma cell viability by Dhakshinamoorthy, Saravanakumar, Sridharan, Shiva Ranjani, Li, Lei, Ng, Poh Yong, Boxer, Linda M, Porter, Alan G

“…Toxic nitric oxide (NO) levels can regulate gene expression. Using a novel protein/DNA array, we show that toxic NO levels regulate the binding of…”
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Apoptosis initiated by dependence receptors: a new paradigm for cell death? by Porter, Alan G., Dhakshinamoorthy, Saravanakumar

“…A distinct group of receptors including DCC, UNC5, RET and Ptc1 is known to function in ligand‐dependent neuronal growth and differentiation or axon guidance…”
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Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens by Dhakshinamoorthy, S, Long, 2nd, D J, Jaiswal, A K

“…Antioxidants are substances that delay or prevent the oxidation of cellular oxidizable substrates. The various antioxidants exert their effect by scavenging…”
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Topoisomerase inhibitor camptothecin sensitizes mouse hepatocytes in vitro and in vivo to TNF‐mediated apoptosis by Hentze, Hannes, Latta, Markus, Künstle, Gerald, Dhakshinamoorthy, Saravanakumar, Ng, Poh Yong, Porter, Alan G., Wendel, Albrecht

“…Topoisomerases are nuclear enzymes that maintain and modulate DNA structure. Inhibitors of topoisomerases like camptothecin (CPT), etoposide, and others are…”
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Site-directed mutagenesis of cysteine to serine in the DNA binding region of Nrf2 decreases its capacity to upregulate antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene by BLOOM, David, DHAKSHINAMOORTHY, Saravanakumar, JAISWAL, Anil K

“…NF-E2 related factor 2 (Nrf2) is a CNC/b-zip protein that regulates antioxidant response element (ARE)-mediated expression, and antioxidant induction, of…”
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Hexanal Vapor Induced Resistance against Major Postharvest Pathogens of Banana (Musa acuminata L.) by Dhakshinamoorthy, Durgadevi, Sundaresan, Srivignesh, Iyadurai, Arumukapravin, Subramanian, Kizhaeral Sevathapandian, Janavi, Gnanaguru Janaki, Paliyath, Gopinathan, Subramanian, Jayasankar

“…Hexanal, a C-6 aldehyde has been implicated to have antimicrobial properties. Hence, this study was conducted to determine the antifungal activities of hexanal…”
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