Search Results - "Dhaene, K."

FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma by Sahin, U., Türeci, Ö., Manikhas, G., Lordick, F., Rusyn, A., Vynnychenko, I., Dudov, A., Bazin, I., Bondarenko, I., Melichar, B., Dhaene, K., Wiechen, K., Huber, C., Maurus, D., Arozullah, A., Park, J.W., Schuler, M., Al-Batran, S.-E.

“…Claudin 18.2 (CLDN18.2) is contained within normal gastric mucosa epithelial tight junctions; upon malignant transformation, CLDN18.2 epitopes become exposed…”
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A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study by Türeci, O., Sahin, U., Schulze-Bergkamen, H., Zvirbule, Z., Lordick, F., Koeberle, D., Thuss-Patience, P., Ettrich, T., Arnold, D., Bassermann, F., Al-Batran, S.E., Wiechen, K., Dhaene, K., Maurus, D., Gold, M., Huber, C., Krivoshik, A., Arozullah, A., Park, J.W., Schuler, M.

“…Claudin 18.2 (CLDN18.2) is physiologically confined to gastric mucosa tight junctions; however, upon malignant transformation, perturbations in cell polarity…”
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Cor pulmonale and respiratory failure in a young woman by Brusselle, G, Van Nooten, G, Delrue, L, Vanwalleghem, L, Dhaene, K, Renard, V, Joos, G

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Telomerase activity in human pleural mesothelioma by Dhaene, Karl, Hübner, Roland, Kumar-Singh, Samir, Weyn, Barbara, Van Marck, Eric

“…BACKGROUND Gradual telomere erosion eventually limits the replicative life span of somatic cells and is regarded as an ultimate tumour suppressor mechanism,…”
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Iodine-Labeled Tamoxifen Uptake in Primary Human Breast Carcinoma by Van de Wiele, Christophe, Cocquyt, Veronique, VandenBroecke, Rudi, De Vos, Filip, Van Belle, Simon, Dhaene, Karl, Slegers, Guido, Dierckx, Rudi Andre

“…Assessing tumor uptake and retention of (123)I-labeled tamoxifen (TX) could increase our understanding of TX's action and the mechanisms involved in resistance…”
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Absence of telomerase activity and telomerase catalytic subunit mRNA in melanocyte cultures by DHAENE, K, VANCOILLIE, G, LAMBERT, J. M, NAEYAERT, J, VAN MARCK, E

“…The classic model of activation of telomerase, for which activity has been found in most cancers including cutaneous malignant melanoma (CMM), dictates that…”
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Standard Versus Extended Lymphadenectomy Associated With Pancreatoduodenectomy in the Surgical Treatment of Adenocarcinoma of the Head of the Pancreas: A Multicenter, Prospective, Randomized Study by Pedrazzoli, Sergio, DiCarlo, Valerio, Dionigi, Renzo, Mosca, Franco, Pederzoli, Paolo, Pasquali, Claudio, Klöppel, Günter, Dhaene, Karl, Michelassi, Fabrizio

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Diagnosis of Cutaneous T-Cell Lymphoma Detecting T-Cell Receptor γ Chain Gene Monoclonality By Denaturing Gradient Gel Electrophoresis by Lapière, K., Dhaene, K., Matthieu, L., Hübner, R., Lambert, J., Marck, E. Van

“…Cutaneous T-cell lymphomas represent a group of malignant lymphoproliferative disorders characterised by the occurrence of a monoclonal population of…”
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Telomeres, telomerase and cancer : an up-date by DHAENE, K, VAN MARCK, E, PARWARESCH, R

“…In the mid 1990s, the hypothesis emerged that the upregulation or re-expression of a telomere-synthesising ribonucleoprotein, called telomerase, is a critical…”
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A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study by Türeci, O, Sahin, U, Schulze-Bergkamen, H, Zvirbule, Z, Lordick, F, Koeberle, D, Thuss-Patience, P, Ettrich, T, Arnold, D, Bassermann, F, Al-Batran, S E, Wiechen, K, Dhaene, K, Maurus, D, Gold, M, Huber, C, Krivoshik, A, Arozullah, A, Park, J W, Schuler, M

“…Claudin 18.2 (CLDN18.2) is physiologically confined to gastric mucosa tight junctions; however, upon malignant transformation, perturbations in cell polarity…”
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Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer by Grunwald, Carolin, Koslowski, Michael, Arsiray, Tülin, Dhaene, Karl, Praet, Marleen, Victor, Anja, Morresi‐Hauf, Alicia, Lindner, Michael, Passlick, Bernward, Lehr, Hans‐Anton, Schäfer, Stephan C., Seitz, Gerhard, Huber, Christoph, Sahin, Ugur, Türeci, Özlem

“…Cancer/germline (CG) antigens represent promising targets for widely applicable mono‐ and multiantigen cancer vaccines for nonsmall cell lung cancer (NSCLC)…”
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In silico strategy for detection of target candidates for antibody therapy of solid tumors by Helftenbein, Gerd, Koslowski, Michael, Dhaene, Karl, Seitz, Gerhard, Sahin, Ugur, Türeci, Özlem

“…In contrast to earlier attempts for the identification of target candidates suitable for monoclonal antibody (mAb) based cancer therapies we concentrated on…”
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Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues by Klamp, Thorsten, Sahin, Ugur, Kyewski, Bruno, Schwendemann, Jochen, Dhaene, Karl, Türeci, Özlem

“…Defects in the autoimmune regulator (AIRE) gene cause the monogenic autoimmune disease autoimmune polyendocrinopathy syndrome type 1 (APS-1), which is…”
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Syndecan-1 expression in malignant mesothelioma: correlation with cell differentiation, WT1 expression, and clinical outcome by Kumar-singh, Samir, Jacobs, Werner, Dhaene, Karl, Weyn, Barbara, Bogers, Johannes, Weyler, Joost, Marck, Eric Van

“…Syndecan‐1 binds basic fibroblast growth factor (bFGF), modulates neovascularization, plays a role in epithelial differentiation and is up‐regulated by WT1…”
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Neonatal pulmonary interstitial glycogen accumulation disorder by SMETS, Koenraad, DHAENE, Karl, SCHELSTRAETE, Petra, MEERSSCHAUT, Valérie, VANHAESEBROUCK, Piet

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SV40 large T-antigen and human pleural mesothelioma : Screening by polymerase chain reaction and tyramine-amplified immunohistochemistry by DHAENE, K, VERHULST, A, VAN MARCK, E

“…DNA-like sequences of the p53 and pRB-inactivating simian virus 40 large T-antigen (SV40 LTag) have recently been found in mesotheliomas in the United States…”
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Expression profile of telomerase subunits in human pleural mesothelioma by Dhaene, Karl, Wauters, Jan, Weyn, Barbara, Timmermans, Jean-Pierre, van Marck, Eric

“…Using the TRAP assay, telomerase activity was previously detected in over 90% of human pleural mesotheliomas (MMs), but not in mesothelial cell cultures…”
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Metastatic follicular dendritic cell sarcoma of the stomach: a case report and review of the literature by Geerts, A, Lagae, E, Dhaene, K, Peeters, M, Waeytens, A, Demetter, P, Cuvelier, C, Defreyne, L, De Vos, M, Pattyn, P

“…Follicular dendritic cell (FDC) sarcomas are rare tumours, typically seen in lymph nodes. However, in about one third of the reported cases, a FDC sarcoma…”
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Absence of telomerase activity and telemorase catalytic subunit mRNA in melanocyte cultures by Dhaene, K, Vancoillie, G, Lambert, J, Naeyaert, J M, Van Marck, E

“…The classic model of activation of telomerase, for which activity has been found in most cancers including cutaneous malignant melanoma (CMM), dictates that…”
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Value of morphometry, texture analysis, densitometry, and histometry in the differential diagnosis and prognosis of malignant mesothelioma by Weyn, Barbara, Van De Wouwer, Gert, Koprowski, Marek, Van Daele, André, Dhaene, Karl, Scheunders, Paul, Jacob, Willem, Van Marck, Eric

“…Malignant mesothelioma is a tumour with increasing incidence due to widespread use of its causative agent, asbestos, in the past decades. The poor survival…”
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