Search Results - "Deymier, Alix C."

Effect of stress on the dissolution/crystallization of apatite in aqueous solution: a thermochemical equilibrium study by Deymier, Alix C, Deymier, Pierre A, Latypov, Marat, Muralidharan, Krishna

“…Bone mineralization is critical to maintaining tissue mechanical function. The application of mechanical stress via exercise promotes bone mineralization via…”
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Beyond dissolution: Xerostomia rinses affect composition and structure of biomimetic dental mineral in vitro by Moynahan, Mikayla M, Wong, Stephanie L, Deymier, Alix C

“…Xerostomia, known as dry mouth, is caused by decreased salivary flow. Treatment with lubricating oral rinses provides temporary relief of dry mouth discomfort;…”
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Micro-mechanical properties of the tendon-to-bone attachment by Deymier, Alix C., An, Yiran, Boyle, John J., Schwartz, Andrea G., Birman, Victor, Genin, Guy M., Thomopoulos, Stavros, Barber, Asa H.

“…[Display omitted] The tendon-to-bone attachment (enthesis) is a complex hierarchical tissue that connects stiff bone to compliant tendon. The attachment site…”
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Cardiac ultrastructure inspired matrix induces advanced metabolic and functional maturation of differentiated human cardiomyocytes by Afzal, Junaid, Liu, Yamin, Du, Wenqiang, Suhail, Yasir, Zong, Pengyu, Feng, Jianlin, Ajeti, Visar, Sayyad, Wasim A., Nikolaus, Joerg, Yankova, Maya, Deymier, Alix C., Yue, Lixia, Kshitiz

“…The vast potential of human induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-CMs) in preclinical models of cardiac pathologies, precision medicine,…”
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X-ray diffraction and in situ pressurization of dentine apatite reveals nanocrystal modulus stiffening upon carbonate removal by Forien, Jean-Baptiste, Uzuhashi, Jun, Ohkubo, Tadakatsu, Hono, Kazuhiro, Luo, Lucy, Schwarcz, Henry P., Deymier, Alix C., Krywka, Christina, Fleck, Claudia, Zaslansky, Paul

“…Bone-like materials comprise carbonated-hydroxyapatite nanocrystals (c-Ap) embedding a fibrillar collagen matrix. The mineral particles stiffen the…”
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Metabolic Acidosis Results in Sexually Dimorphic Response in the Heart Tissue by Liu, Yamin, Atiq, Amina, Peterson, Anna, Moody, Mikayla, Novin, Ashkan, Deymier, Alix C, Afzal, Junaid, Kshitiz

“…Metabolic acidosis (MA) is a highly prevalent disorder in a significant proportion of the population, resulting from imbalance in blood pH homeostasis. The…”
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Tunability of collagen matrix mechanical properties via multiple modes of mineralization by Smith, Lester J., Deymier, Alix C., Boyle, John J., Li, Zhen, Linderman, Stephen W., Pasteris, Jill D., Xia, Younan, Genin, Guy M., Thomopoulos, Stavros

“…Functionally graded, mineralized collagen tissues exist at soft-to-hard material attachments throughout the body. However, the details of how collagen and…”
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The multiscale structural and mechanical effects of mouse supraspinatus muscle unloading on the mature enthesis by Deymier, Alix C., Schwartz, Andrea G., Cai, Zhounghou, Daulton, Tyrone L., Pasteris, Jill D., Genin, Guy M., Thomopoulos, Stavros

“…[Display omitted] The musculoskeletal system is sensitive to its loading environment; this is of particular concern under conditions such as disuse, paralysis,…”
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Protein-free formation of bone-like apatite: New insights into the key role of carbonation by Deymier, Alix C, Nair, Arun K, Depalle, Baptiste, Qin, Zhao, Arcot, Kashyap, Drouet, Christophe, Yoder, Claude H, Buehler, Markus J, Thomopoulos, Stavros, Genin, Guy M, Pasteris, Jill D

“…Abstract The nanometer-sized plate-like morphology of bone mineral is necessary for proper bone mechanics and physiology. However, mechanisms regulating the…”
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Multiscale effects of spaceflight on murine tendon and bone by Deymier, Alix C., Schwartz, Andrea G., Lim, Chanteak, Wingender, Brian, Kotiya, Akhilesh, Shen, Hua, Silva, Matthew J., Thomopoulos, Stavros

“…Despite a wealth of data on the effects of spaceflight on tendons and bones, little is known about its effects on the interfacial tissue between these two…”
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Inhibition of miR-29-3p isoforms via tough decoy suppresses osteoblast function in homeostasis but promotes intermittent parathyroid hormone-induced bone anabolism by Hrdlicka, Henry C., Pereira, Renata C., Shin, Bongjin, Yee, Siu-Pok, Deymier, Alix C., Lee, Sun-Kyeong, Delany, Anne M.

“…miRNAs play a vital role in post-transcriptional regulation of gene expression in osteoblasts and osteoclasts, and the miR-29 family is expressed in both…”
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PRG4 deficiency in mice alters skeletal structure, mechanics, and calvarial osteoclastogenesis, and rhPRG4 inhibits in vitro osteoclastogenesis by Tanguay, Adam P., Menon, Nikhil G., Boudreau, Margaret H., Jastrzebski, Sandra, Woods, Paige S., Doyle, Erica A., Edwards, W. Brent, Jay, Gregory D., Deymier, Alix C., Lorenzo, Joseph, Lee, Sun‐Kyeong, Schmidt, Tannin A.

“…Osteoporosis is a chronic disease characterized by reduced bone mass and increased fracture risk, estimated to affect over 10 million people in the United…”
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Effects of spaceflight on the muscles of the murine shoulder by Shen, Hua, Lim, Chanteak, Schwartz, Andrea G., Andreev‐Andrievskiy, Alexander, Deymier, Alix C., Thomopoulos, Stavros

“…ABSTRACT Mechanical loading is necessary for the development and maintenance of the musculoskeletal system. Removal of loading via microgravity, paralysis, or…”
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A Systems Approach to Biomechanics, Mechanobiology, and Biotransport by Peirce-Cottler, Shayn M, Sander, Edward A, Fisher, Matthew B, Deymier, Alix C, LaDisa, Jr, John F, O'Connell, Grace, Corr, David T, Han, Bumsoo, Singh, Anita, Wilson, Sara E, Lai, Victor K, Clyne, Alisa Morss

“…The human body represents a collection of interacting systems that range in scale from nanometers to meters. Investigations from a systems perspective focus on…”
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The concentration of stress at the rotator cuff tendon-to-bone attachment site is conserved across species by Saadat, Fatemeh, Deymier, Alix C., Birman, Victor, Thomopoulos, Stavros, Genin, Guy M.

“…The tendon-to-bone attachment site integrates two distinct tissues via a gradual transition in composition, mechanical properties, and structure. Outcomes of…”
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Effect of high-energy X-ray doses on bone elastic properties and residual strains by Singhal, A., Deymier-Black, Alix C., Almer, J.D., Dunand, D.C.

“…Bone X-ray irradiation occurs during medical treatments, sterilization of allografts, space travel and in vitro studies. High doses are known to affect the…”
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Effect of high-energy X-ray irradiation on creep mechanisms in bone and dentin by Deymier-Black, Alix C., Singhal, Anjali, Yuan, Fang, Almer, Jonathan D., Brinson, L. Catherine, Dunand, David C.

“…Under long-term loading creep conditions, mineralized biological tissues like bone are expected to behave in a similar manner to synthetic composites where the…”
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Allometry of the Tendon Enthesis: Mechanisms of Load Transfer Between Tendon and Bone by Deymier-Black, Alix C, Pasteris, Jill D, Genin, Guy M, Thomopoulos, Stavros

“…Several features of the tendon-to-bone attachment were examined allometrically to determine load transfer mechanisms. The humeral head diameter increased…”
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Phosphate and buffer capacity effects on biomimetic carbonate apatite by Wong, Stephanie L., Deymier, Alix C.

“…With the increasing use of carbonated apatite (CAp) in biomedical devices, it has become necessary to understand how this thermodynamically unstable mineral…”
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Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties by Gallant, Maxime A, Brown, Drew M, Hammond, Max, Wallace, Joseph M, Du, Jiang, Deymier-Black, Alix C, Almer, Jonathan D, Stock, Stuart R, Allen, Matthew R, Burr, David B

“…Abstract Raloxifene is an FDA approved agent used to treat bone loss and decrease fracture risk. In clinical trials and animal studies, raloxifene reduces…”
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