Search Results - "Deycmar, Simon"

Activation of efficient DNA repair mechanisms after photon and proton irradiation of human chondrosarcoma cells by Lohberger, Birgit, Glänzer, Dietmar, Eck, Nicole, Kerschbaum-Gruber, Sylvia, Mara, Elisabeth, Deycmar, Simon, Madl, Tobias, Kashofer, Karl, Georg, Petra, Leithner, Andreas, Georg, Dietmar

“…Although particle therapy with protons has proven to be beneficial in the treatment of chondrosarcoma compared to photon-based (X-ray) radiation therapy, the…”
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Investigating the impact of alpha/beta and LETd on relative biological effectiveness in scanned proton beams: An in vitro study based on human cell lines by Mara, Elisabeth, Clausen, Monika, Khachonkham, Suphalak, Deycmar, Simon, Pessy, Clara, Dörr, Wolfgang, Kuess, Peter, Georg, Dietmar, Gruber, Sylvia

“…Purpose A relative biological effectiveness (RBE) of 1.1 is commonly used in clinical proton therapy, irrespective of tissue type and depth. This in vitro…”
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Polymer-Ligand-Based ELISA for Robust, High-Throughput, Quantitative Detection of p53 Aggregates by Maritschnegg, Elisabeth, Heinzl, Nicole, Wilson, Stuart, Deycmar, Simon, Niebuhr, Markus, Klameth, Lukas, Holzer, Barbara, Koziel, Katarzyna, Concin, Nicole, Zeillinger, Robert

“…A growing number of diseases are being linked to protein misfolding and amyloid formation. Recently, p53 was also shown to associate into amyloid aggregates,…”
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Assessing cerebrovascular reactivity (CVR) in rhesus macaques (Macaca mulatta) using a hypercapnic challenge and pseudo-continuous arterial spin labeling (pCASL) by Johnson, Brendan J, Lipford, Megan E, Barcus, Richard A, Olson, John D, Schaaf, George W, Andrews, Rachel N, Kim, Jeongchul, Dugan, Greg O, Deycmar, Simon, Reed, Colin A, Whitlow, Christopher T, Cline, J Mark

“…Cerebrovascular reactivity (CVR) is a measure of cerebral small vessels' ability to respond to changes in metabolic demand and can be quantified using magnetic…”
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Ganetespib selectively sensitizes cancer cells for proximal and distal spread-out Bragg peak proton irradiation by Deycmar, Simon, Mara, Elisabeth, Kerschbaum-Gruber, Sylvia, Waller, Verena, Georg, Dietmar, Pruschy, Martin

“…Hypersensitivity towards proton versus photon irradiation was demonstrated in homologous recombination repair (HRR)-deficient cell lines. Hence, combined…”
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Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques by Deycmar, Simon, Johnson, Brendan J, Ray, Karina, Schaaf, George W, Ryan, Declan Patrick, Cullin, Cassandra, Dozier, Brandy L, Ferguson, Betsy, Bimber, Benjamin N, Olson, John D, Caudell, David L, Whitlow, Christopher T, Solingapuram Sai, Kiran Kumar, Romero, Emily C, Villinger, Francois J, Burgos, Armando G, Ainsworth, Hannah C, Miller, Lance D, Hawkins, Gregory A, Chou, Jeff W, Gomes, Bruno, Hettich, Michael, Ceppi, Maurizio, Charo, Jehad, Cline, J Mark

“…Naturally occurring colorectal cancers (CRC) in rhesus macaques share many features with their human counterparts and are useful models for cancer…”
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Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining by Szymonowicz, Klaudia, Krysztofiak, Adam, Linden, Jansje van der, Kern, Ajvar, Deycmar, Simon, Oeck, Sebastian, Squire, Anthony, Koska, Benjamin, Hlouschek, Julian, Vüllings, Melanie, Neander, Christian, Siveke, Jens T, Matschke, Johann, Pruschy, Martin, Timmermann, Beate, Jendrossek, Verena

“…Technical improvements in clinical radiotherapy for maximizing cytotoxicity to the tumor while limiting negative impact on co-irradiated healthy tissues…”
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Small RNAs and the competing endogenous RNA network in high grade serous ovarian cancer tumor spread by Bachmayr-Heyda, Anna, Auer, Katharina, Sukhbaatar, Nyamdelger, Aust, Stefanie, Deycmar, Simon, Reiner, Agnes T, Polterauer, Stephan, Dekan, Sabine, Pils, Dietmar

“…High grade serous ovarian cancer (HGSOC) is among the most deadly malignancies in women, frequently involving peritoneal tumor spread. Understanding molecular…”
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7 Local and peripheral response to pembrolizumab ± radiotherapy in rhesus macaques with naturally-occurring dMMR colorectal cancer by Deycmar, Simon, Schaaf, George W, Johnson, Brendan J, Daniel Bourland, J, Ververs, James D, Whitlow, Christopher T, Mark Cline, J

“…BackgroundRhesus macaques share extensive similarities with humans including immune cell populations, regulatory mechanisms, and targets for cancer…”
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11 Molecular characterization of naturally occurring colorectal and breast cancer in non-human primates to model human immunotherapeutic agents by Deycmar, Simon, Johnson, Brendan, Ryan, Declan, Sills, William, Caudell, David, Dugan, Greg, Sai, Kiran Solingapuram, Hettich, Michael, Gomes, Bruno, Ceppi, Maurizio, Cline, Mark

“…BackgroundNon-human primates (NHP) with naturally occurring cancers (also called tumor-bearing monkeys or TBM) are a proposed model for translational cancer…”
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Combined Treatment Modalities for High-Energy Proton Irradiation: Exploiting Specific DNA Repair Dependencies by Deycmar, Simon, Pruschy, Martin

“…DNA repair deficiencies and genome instability are common features and hallmarks of cancer and are ubiquitously found in the full spectrum of malignant…”
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Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy by Deycmar, Simon, Gomes, Bruno, Charo, Jehad, Ceppi, Maurizio, Cline, J Mark

“…The complexity of cancer immunotherapy (CIT) demands reliable preclinical models to successfully translate study findings to the clinics. Non-human primates…”
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Investigating the impact of alpha/beta and LET d on relative biological effectiveness in scanned proton beams: An in vitro study based on human cell lines by Mara, Elisabeth, Clausen, Monika, Khachonkham, Suphalak, Deycmar, Simon, Pessy, Clara, Dörr, Wolfgang, Kuess, Peter, Georg, Dietmar, Gruber, Sylvia

“…A relative biological effectiveness (RBE) of 1.1 is commonly used in clinical proton therapy, irrespective of tissue type and depth. This in vitro study was…”
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Total-Body Irradiation Alters White Matter Volume and Microstructural Integrity in Rhesus Macaques by Johnson, Brendan J., Barcus, Richard A., Olson, John D., Lipford, Megan E., Andrews, Rachel N., Dugan, Greg O., Tooze, Janet A., Kim, Jeongchul, Deycmar, Simon, Whitlow, Christopher T., Cline, J. Mark

“…Long-term survivors of brain irradiation can experience irreversible injury and cognitive impairment. T1-weighted and diffusion tensor magnetic resonance…”
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The relative biological effectiveness of proton irradiation in dependence of DNA damage repair by Deycmar, Simon, Faccin, Erica, Kazimova, Tamara, Knobel, Philip A, Telarovic, Irma, Tschanz, Fabienne, Waller, Verena, Winkler, Rona, Yong, Carmen, Zingariello, Dario, Pruschy, Martin

“…Clinical parameters and empirical evidence are the primary determinants for current treatment planning in radiation oncology. Personalized medicine in…”
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Abstract 5203: Naturally occurring colorectal cancer in rhesus macaques as model for human cancer immunotherapy: a first report on pembrolizumab ± radiotherapy by Deycmar, Simon, Schaaf, George W., Johnson, Brendan J., Bourland, J. Daniel, Ververs, James D., Whitlow, Christopher T., Cline, J. Mark

“…Abstract Introduction: Rhesus macaques share extensive similarities with humans including immune cell populations, regulatory mechanisms, and targets for…”
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Abstract B56: Peritoneal tumor spread in high grade serous ovarian cancer: An effect of the competing endogenous RNA network? by Bachmayr-Heyda, Anna, Auer, Katharina, Sukhbaatar, Nyamdelger, Aust, Stefanie, Deycmar, Simon, Reiner, Agnes T., Polterauer, Stephan, Dekan, Sabine, Pils, Dietmar

“…Abstract Epithelial ovarian cancer (EOC) is still one of the deadliest malignancies in women frequently involving peritoneal tumor spread and ascites. Despite…”
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Two different, mutually exclusively distributed, TP53 mutations in ovarian and peritoneal tumor tissues of a serous ovarian cancer patient: indicative for tumor origin? by Sukhbaatar, Nyamdelger, Bachmayr-Heyda, Anna, Auer, Katharina, Aust, Stefanie, Deycmar, Simon, Horvat, Reinhard, Pils, Dietmar

“…High-grade serous ovarian cancer (HGSOC) is characterized by a mutation rate of up to 96.7% and associated with a more aggressive tumor biology. The origin of…”
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Abstract A021: Clinical and molecular characterization of naturally-occurring colorectal cancer in rhesus macaques reveals mismatch repair deficiency driven by epigenetic silencing of MLH1 by Deycmar, Simon, Johnson, Brendan, Ray, Karina, Caudell, David Caudell, Olson, John, Dugan, Greg, Sills, W. Shane, Ryan, Declan, Whitlow, Christopher, Sai, Kiran K. Solingapuram, Ferguson, Betsy, Bimber, Benjamin, Cullin, Cassandra, Dozier, Brandy, Romero, Emily, Villinger, Francois, Burgos, Armando, Chou, Jeff, Gomes, Bruno, Hettich, Michael, Ceppi, Maurizio, Charo, Jehad, Cline, J. Mark

“…Abstract Naturally occurring colorectal cancers (CRC) in rhesus macaques share many features with their human counterparts and emerge at similar life stages as…”
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Abstract 1325: Naturally occurring colorectal cancer in nonhuman primates used to study human immunotherapeutic agents confirms a link between DNA methylation and mismatch repair deficiency by Deycmar, Simon, Johnson, Brendan, Ryan, Declan, Sills, Shane, Caudell, David, Dugan, Greg, Schaaf, George, Whitlow, Christopher, Sai, Kiran Kumar Solingapuram, Ferguson, Betsy, Bimber, Benjamin, Ray, Karina, Cullin, Cassandra, Dozier, Brandy, Burgos, Armando, Hettich, Michael, Gomes, Bruno, Charo, Jehad, Ceppi, Maurizio, Cline, Mark

“…Abstract Background Non-human primates (NHP) such as rhesus macaques with naturally occurring cancers are a proposed model for translational cancer…”
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