Search Results - "Dey, Vishakha"
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mRNA cap-binding protein eIF4E1 is a novel regulator of Toxoplasma gondii latency
Published in mBio (12-06-2024)“…The protozoan parasite causes serious opportunistic disease due to its ability to persist in patients as latent tissue cysts. The molecular mechanisms…”
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Membrane and luminal proteins reach the apicoplast by different trafficking pathways in the malaria parasite Plasmodium falciparum
Published in PeerJ (San Francisco, CA) (27-04-2017)“…The secretory pathway in has evolved to transport proteins to the host cell membrane and to an endosymbiotic organelle, the apicoplast. The latter can occur…”
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High-Throughput Screening to Identify Inhibitors of Plasmodium falciparum Importin α
Published in Cells (Basel, Switzerland) (02-04-2022)“…The global burden of malaria and toxoplasmosis has been limited by the use of efficacious anti-parasitic agents, however, emerging resistance in species and…”
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Molecular basis for the lack of auto-inhibition of Plasmodium falciparum importin α
Published in Biochemical and biophysical research communications (10-09-2018)“…Importin α is nuclear transport receptor that recognises nuclear localisation sequences (NLS). The protein has two domains: armadillo (ARM) repeats containing…”
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Toxoplasma Gondii Importin [alpha] Shows Weak Auto-Inhibition
Published in The protein journal (01-08-2023)“…Importin [alpha] is a nuclear transporter that binds to nuclear localization signals (NLSs), consisting of 7-20 positively charged amino acids found within…”
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Toxoplasma Gondii Importin α Shows Weak Auto-Inhibition
Published in The protein journal (01-08-2023)“…Importin α is a nuclear transporter that binds to nuclear localization signals (NLSs), consisting of 7–20 positively charged amino acids found within cargo…”
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7
Cap-independent translation directs stress-induced differentiation of the protozoan parasite Toxoplasma gondii
Published in The Journal of biological chemistry (12-11-2024)“…Translational control mechanisms modulate microbial latency of eukaryotic pathogens, enabling them to evade immunity and drug treatments. The protozoan…”
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An insertion in the methyltransferase domain of P. falciparum trimethylguanosine synthase harbors a classical nuclear localization signal
Published in Molecular and biochemical parasitology (01-11-2016)“…[Display omitted] •The methyltransferase domain of P. falciparum TGS1 (PfTGS1) has an insertion containing a predicted nuclear localization signal (NLS).•This…”
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