Search Results - "Dey, Raja"

Nanomaterials for cancer therapy: current progress and perspectives by Cheng, Zhe, Li, Maoyu, Dey, Raja, Chen, Yongheng

“…Abstract Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction of…”
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Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer by Chen, Yongheng, Dey, Raja, Chen, Lin

“…Recent studies suggest that p53 binds predominantly to consensus sites composed of two decameric half-sites with zero spacing in vivo. Here we report the…”
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Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor by Su, Minfei, Zhu, Lan, Zhang, Yixiao, Paknejad, Navid, Dey, Raja, Huang, Jianyun, Lee, Ming-Yue, Williams, Dewight, Jordan, Kelsey D., Eng, Edward T., Ernst, Oliver P., Meyerson, Joel R., Hite, Richard K., Walz, Thomas, Liu, Wei, Huang, Xin-Yun

“…Cardiac disease remains the leading cause of morbidity and mortality worldwide. The β1-adrenergic receptor (β1-AR) is a major regulator of cardiac functions…”
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Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2 by Nader, Nancy, Dib, Maya, Hodeify, Rawad, Courjaret, Raphael, Elmi, Asha, Hammad, Ayat S, Dey, Raja, Huang, Xin-Yun, Machaca, Khaled

“…The steroid hormone progesterone (P4) mediates many physiological processes through either nuclear receptors that modulate gene expression or membrane P4…”
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Correction: Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2 by Nader, Nancy, Dib, Maya, Hodeify, Rawad, Courjaret, Raphael, Elmi, Asha, Hammad, Ayat S, Dey, Raja, Huang, Xin-Yun, Machaca, Khaled

“…[This corrects the article DOI: 10.1371/journal.pbio.3000901.]…”
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DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation by Chen, Yongheng, Bates, Darren L., Dey, Raja, Chen, Po-Han, Machado, Ana Carolina Dantas, Laird-Offringa, Ite A., Rohs, Remo, Chen, Lin

“…GATA transcription factors regulate transcription during development and differentiation by recognizing distinct GATA sites with a tandem of two conserved zinc…”
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A cytokine-cytokine interaction in the assembly of higher-order structure and activation of the interleukine-3:receptor complex by Dey, Raja, Ji, Kunmei, Liu, Zhigang, Chen, Lin

“…Interleukine-3 (IL-3) binds its receptor and initiates a cascade of signaling processes that regulate the proliferation and differentiation of hematopoietic…”
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In Search of Allosteric Modulators of α7-nAChR by Solvent Density Guided Virtual Screening by Dey, Raja, Chen, Lin

“…Nicotinic acetylcholine receptors (nAChR) are pentameric ligand gated ion channels whose activity can be modulated by endogenous neurotransmitters as well as…”
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Estrogen-related receptor alpha directly binds to p53 and cooperatively controls colon cancer growth through the regulation of mitochondrial biogenesis and function by De Vitto, Humberto, Ryu, Joohyun, Calderon-Aparicio, Ali, Monts, Josh, Dey, Raja, Chakraborty, Abhijit, Lee, Mee-Hyun, Bode, Ann M, Dong, Zigang

“…Of the genes that control mitochondrial biogenesis and function, ERRα emerges as a druggable metabolic target to be exploited for cancer therapy. Of the genes…”
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A proposed atomic model of the head-to-tail interaction in the filament structure of vimentin by Dey, Raja, Burkhard, Peter

“…Communicated by Ramaswamy H. Sarma…”
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Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor by Huang, Jianyun, Dey, Raja, Wang, Yufeng, Jakoncic, Jean, Kurinov, Igor, Huang, Xin-Yun

“…Tumor metastasis is responsible for ~90% of all cancer deaths. One of the key steps of tumor metastasis is tumor cell migration and invasion. Filopodia are…”
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Regulation, Signaling, and Physiological Functions of G-Proteins by Syrovatkina, Viktoriya, Alegre, Kamela O., Dey, Raja, Huang, Xin-Yun

“…Heterotrimeric guanine-nucleotide-binding regulatory proteins (G-proteins) mainly relay the information from G-protein-coupled receptors (GPCRs) on the plasma…”
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Structural insights into the HDAC4–MEF2A–DNA complex and its implication in long-range transcriptional regulation by Dai, Shuyan, Guo, Liang, Dey, Raja, Guo, Ming, Zhang, Xiangqian, Bates, Darren, Cayford, Justin, Jiang, Longying, Wei, Hudie, Chen, Zhuchu, Zhang, Ye, Chen, Lin, Chen, Yongheng

“…Abstract Class IIa Histone deacetylases (HDACs), including HDAC4, 5, 7 and 9, play key roles in multiple important developmental and differentiation processes…”
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Nanoscale assemblies and their biomedical applications by Doll, Tais A. P. F., Raman, Senthilkumar, Dey, Raja, Burkhard, Peter

“…Nanoscale assemblies are a unique class of materials, which can be synthesized from inorganic, polymeric or biological building blocks. The multitude of…”
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Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins by Aziz, Faisal, Reddy, Kanamata, Fernandez Vega, Virneliz, Dey, Raja, Hicks, Katherine A., Rao, Sumitha, Jordan, Luis Ortiz, Smith, Emery, Shumate, Justin, Scampavia, Louis, Carpino, Nicholas, Spicer, Timothy P., French, Jarrod B.

“…The suppressor of T cell receptor signaling (Sts) proteins are negative regulators of immune signaling. Genetic inactivation of these proteins leads to…”
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Human uridine 5′-monophosphate synthase stores metabolic potential in inactive biomolecular condensates by Kim-Holzapfel, Deborah M., Dey, Raja, Richardson, Brian C., Arachchige, Danushka, Reddy, Kanamata, De Vitto, Humberto, Bhandari, Janarjan, French, Jarrod B.

“…Human uridine 5′-monophosphate synthase (HsUMPS) is a bifunctional enzyme that catalyzes the final two steps in de novo pyrimidine biosynthesis. The individual…”
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Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor by Huang, Jianyun, Dey, Raja, Wang, Yufeng, Jakoncic, Jean, Kurinov, Igor, Huang, Xin-Yun

“…Tumor metastasis is responsible for ~ 90% of all cancer deaths. One of the key steps of tumor metastasis is tumor cell migration and invasion. Filopodia are…”
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Design and optimization of peptide nanoparticles by Doll, Tais A P F, Dey, Raja, Burkhard, Peter

“…Various supra-molecular structures form by self-assembly of proteins in a symmetric fashion. Examples of such structures are viruses, some bacterial…”
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Structure of the MADS-box/MEF2 Domain of MEF2A Bound to DNA and Its Implication for Myocardin Recruitment by Wu, Yongqing, Dey, Raja, Han, Aidong, Jayathilaka, Nimanthi, Philips, Michael, Ye, Jun, Chen, Lin

“…Myocyte enhancer factor 2 (MEF2) regulates specific gene expression in diverse developmental programs and adaptive responses. MEF2 recognizes DNA and interacts…”
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Studies on the interaction of -epigallocatechin-3-gallate from green tea with bovine β-lactoglobulin by spectroscopic methods and docking by WU, XULI, DEY, RAJA, WU, HUI, LIU, ZHIGANG, HE, QINGQING, ZENG, XIAOJUAN

“…The binding interaction between‐epigallocatechin‐3‐gallate (EGCG) and bovine β‐lactoglobulin (βLG) was thoroughly studied by fluorescence, circular dichroism…”
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