Search Results - "Dexter, T.M"

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors by Fairbairn, L J, Cowling, G J, Reipert, B M, Dexter, T M

“…In the absence of growth factors, hemopoietic cells die rapidly by the process of apoptosis. Transfection of the human bcl-2 gene into an interleukin-3…”
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Cancer Surveys-Maturation and Differentiation in Leukaemias Vol. 1. No 2 by Dexter, T.M

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Blood cell development: The message in the medium by Dexter, T.M

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Do Stem Cells Play Dice? by Enver, T., Heyworth, C.M., Dexter, T.M.

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Ultrastructural aspects of erythropoietic differentiation in long-term bone marrow culture by Allen, T D, Dexter, T M

“…Long-term liquid cultures of mouse bone marrow produce stem cell (CFU-S) and differentiated granulocytes for many months. Addition of AMS (anaemic mouse serum)…”
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Tissue culture - use or abuse? by Dexter, T.M

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Comparison of haemopoiesis in young and old mice by Schofield, R, Dexter, T M, Lord, B I, Testa, N G

“…Haemopoietic status and functions have been compared in young (2-3-month-old) and old (2-2.5-year-old) BDF1 mice. The parameters measured include total marrow…”
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Effect of Campath-1H Antibody on Human Hematopoietic Progenitors In Vitro by Gilleece, M.H., Dexter, T.M.

“…The humanized antibody CAMPATH-1 H has been shown in pilot studies to be beneficial in the treatment of lymphoid malignancy and other lymphoproliferative…”
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Transplantation Potential of Peripheral Blood Stem Cells Induced by Granulocyte Colony-Stimulating Factor by Molineux, G., Pojda, Z., Hampson, I.N., Lord, B.I., Dexter, T.M.

“…The major effect of granulocyte colony-stimulating factor (G-CSF) is to induce neutrophilia in previously untreated animals or after chemotherapy or marrow…”
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The Kinetics of Human Granulopoiesis Following Treatment with Granulocyte Colony-Stimulating Factor in vivo by Lord, B. I., Bronchud, M. H., Owens, S., Chang, J., Howell, A., Souza, L., Dexter, T. M.

“…Cell proliferation in the bone marrow and blood of two patients with metastatic breast cancer who were treated with granulocyte colony-stimulating factor was…”
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Increased Numbers of Long-Term Culture-Initiating Cells in the Apheresis Product of Patients Randomized to Receive Increasing Doses of Stem Cell Factor Administered in Combination With Chemotherapy and a Standard Dose of Granulocyte Colony-Stimulating Factor by Weaver, A., Ryder, D., Crowther, D., Dexter, T.M., Testa, N.G.

“…Long-term culture-initiating cells (LTC-IC) are arguably the most primitive human hematopoietic cells detectable by in vitro functional assays. We have…”
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Growth of human umbilical-cord blood in longterm haemopoietic cultures by Hows, J M, Bradley, B A, Marsh, J C, Luft, T, Coutinho, L, Testa, N G, Dexter, T M

“…Cryopreserved human umbilical-cord (HUC) blood is an alternative to bone marrow as a source of haemopoietic "stem" cells for HLA-identical transplantation of…”
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A Comparison of Hematopoiesis in Normal and Splenectomized Mice Treated With Granulocyte Colony-Stimulating Factor by Molineux, G., Pojda, Z., Dexter, T.M.

“…Recombinant human granulocyte colony-stimulating factor (rhG-CSF) induces leukocytosis in vivo in both intact and splenectomized mice. Full dose response data…”
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The Effects on Hematopoiesis of Recombinant Stem Cell Factor (Ligand for c-kit) Administered In Vivo to Mice Either Alone or in Combination With Granulocyte Colony-Stimulating Factor by Molineux, G., Migdalska, A., Szmitkowski, M., Zsebo, K., Dexter, T.M.

“…Stem cell factor (SCF) is the ligand for the receptor encoded by the c-kit proto-oncogene. Mutations of either c-kit or the SCF gene are responsible for the…”
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The Hematopoietic Defect in Aplastic Anemia Assessed by Long-Term Marrow Culture by Marsh, J.C.W., Chang, J., Testa, N.G., Hows, J.M., Dexter, T.M.

“…Thirty-two patients with aplastic anemia (AA) have been studied using the long-term bone marrow culture (LTBMC) system. Of these patients, 26 had been treated…”
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Myeloid Cell Kinetics in Mice Treated With Recombinant Interleukin-3, Granulocyte Colony-Stimulating Factor (CSF), or Granulocyte-Macrophage CSF In Vivo by Lord, B.I., Molineux, G., Pojda, Z., Souza, L.M., Mermod, J.-J., Dexter, T.M.

“…Myeloid cell kinetics in mice treated with pure hematopoietic growth factors have been investigated using tritiated thymidine labeling and autoradiography…”
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Macrophage-Inflammatory Protein Protects Multipotent Hematopoietic Cells From the Cytotoxic Effects of Hydroxyurea In Vivo by Lord, B.l., Dexter, T.M., Clements, J.M., Hunter, M.A., Gearing, A.J.H.

“…Macrophage inflammatory protein-1 α (MIP-1α) has been assessed for its potential in vivo to protect hematopoietic progenitor cells from the cytotoxic effects…”
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Do Stem Cells Play Dice? by Enver, T., Heyworth, C.M., Dexter, T.M.

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BB-10010: An Active Variant of Human Macrophage Inflammatory Protein-1α With Improved Pharmaceutical Properties by Hunter, M.G., Bawden, L., Brotherton, D., Craig, S., Cribbes, S., Czaplewski, L.G., Dexter, T.M., Drummond, A.H., Gearing, A.H., Heyworth, C.M., Lord, B.I., McCourt, M., Varley, P.G., Wood, L.M., Edwards, R.M., Lewis, P.J.

“…The stem cell inhibitor, macrophage inflammatory protein-1α (MIP-1α) or LD78, protects multipotent hematopoietic progenitors in murine models from the…”
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Identification of a Serpin Specifically Expressed in Multipotent and Bipotent Hematopoietic Progenitor Cells and in Activated T Cells by Hampson, I.N., Hampson, L., Pinkoski, M., Cross, M., Heyworth, C.M., Bleackley, R.C., Atkinson, E., Dexter, T.M.

“…We have identified a gene that has a high level of mRNA expression in undifferentiated, multipotential hematopoietic cells (FDCP-Mix) and that downregulates…”
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