Search Results - "Dexter, T M"

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors by Fairbairn, L J, Cowling, G J, Reipert, B M, Dexter, T M

“…In the absence of growth factors, hemopoietic cells die rapidly by the process of apoptosis. Transfection of the human bcl-2 gene into an interleukin-3…”
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Effect of Campath-1H Antibody on Human Hematopoietic Progenitors In Vitro by Gilleece, M.H., Dexter, T.M.

“…The humanized antibody CAMPATH-1 H has been shown in pilot studies to be beneficial in the treatment of lymphoid malignancy and other lymphoproliferative…”
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Growth factors in development, transformation, and tumorigenesis by Cross, M, Dexter, T M

“…Mammalian tissue development and regeneration take place within a milieu of regulatory growth factors. These affect many parameters of cell development, such…”
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Transplantation Potential of Peripheral Blood Stem Cells Induced by Granulocyte Colony-Stimulating Factor by Molineux, G., Pojda, Z., Hampson, I.N., Lord, B.I., Dexter, T.M.

“…The major effect of granulocyte colony-stimulating factor (G-CSF) is to induce neutrophilia in previously untreated animals or after chemotherapy or marrow…”
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Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants by Wynn, Robert F, Cross, Michael A, Hatton, Claire, Will, Andrew M, Lashford, Linda S, Dexter, T Michael, Testa, Nydia G

“…The establishment of donor-derived haemopoiesis in the recipients of allogeneic bone-marrow transplants (BMT) involves extensive proliferation of haemopoietic…”
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Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis by Roberts, R, Gallagher, J, Spooncer, E, Alien, T. D, Bloomfield, F, Dexter, T. M

“…The proliferation and development of haemopoietic stem cells takes place in close association with marrow stromal cells. This intimate cell contact presumably…”
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Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer by BRONCHUD, M. H, SCARFFE, J. H, THATCHER, N, CROWTHER, D, SOUZA, L. M, ALTON, N. K, TESTA, N. G, DEXTER, T. M

“…Twelve patients with advanced small cell carcinoma of the bronchus were treated by continuous infusion of recombinant human granulocyte colony-stimulating…”
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The Kinetics of Human Granulopoiesis Following Treatment with Granulocyte Colony-Stimulating Factor in vivo by Lord, B. I., Bronchud, M. H., Owens, S., Chang, J., Howell, A., Souza, L., Dexter, T. M.

“…Cell proliferation in the bone marrow and blood of two patients with metastatic breast cancer who were treated with granulocyte colony-stimulating factor was…”
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A Comparison of Hematopoiesis in Normal and Splenectomized Mice Treated With Granulocyte Colony-Stimulating Factor by Molineux, G., Pojda, Z., Dexter, T.M.

“…Recombinant human granulocyte colony-stimulating factor (rhG-CSF) induces leukocytosis in vivo in both intact and splenectomized mice. Full dose response data…”
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Multicyclic, dose-intensive chemotherapy supported by sequential reinfusion of hematopoietic progenitors in whole blood by Pettengell, R, Woll, P J, Thatcher, N, Dexter, T M, Testa, N G

“…To support multicyclic, dose-intensive chemotherapy, we assessed the effects of reinfusing hematopoietic progenitors collected at each cycle in leukapheresis…”
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The Effects on Hematopoiesis of Recombinant Stem Cell Factor (Ligand for c-kit) Administered In Vivo to Mice Either Alone or in Combination With Granulocyte Colony-Stimulating Factor by Molineux, G., Migdalska, A., Szmitkowski, M., Zsebo, K., Dexter, T.M.

“…Stem cell factor (SCF) is the ligand for the receptor encoded by the c-kit proto-oncogene. Mutations of either c-kit or the SCF gene are responsible for the…”
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The use of granulocyte colony-stimulating factor to increase the intensity of treatment with doxorubicin in patients with advanced breast and ovarian cancer by BRONCHUD, M. H, HOWELL, A, CROWTHER, D, HOPWOOD, P, SOUZA, L, DEXTER, T. M

“…Granulocyte colony stimulating factor (G-CSF) was given to 17 patients with advanced breast and ovarian cancer in order to increase the intensity and…”
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Direct Comparison by Limiting Dilution Analysis of Long-Term Culture-Initiating Cells in Human Bone Marrow, Umbilical Cord Blood, and Blood Stem Cells by Pettengell, Ruth, Luft, Thomas, Henschler, Reinhard, Hows, Jill M., Dexter, T. Michael, Ryder, David, Testa, Nydia G.

“…Limiting-dilution analysis of long-term culture-initiating cells (LTCIC) is a quantitative method of estimating hematopoietic stem cell activity in clinical…”
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Growth of human umbilical-cord blood in longterm haemopoietic cultures by Hows, J M, Bradley, B A, Marsh, J C, Luft, T, Coutinho, L, Testa, N G, Dexter, T M

“…Cryopreserved human umbilical-cord (HUC) blood is an alternative to bone marrow as a source of haemopoietic "stem" cells for HLA-identical transplantation of…”
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Randomized comparison of progenitor-cell mobilization using chemotherapy, stem-cell factor, and filgrastim or chemotherapy plus filgrastim alone in patients with ovarian cancer by Weaver, A, Chang, J, Wrigley, E, de Wynter, E, Woll, P J, Lind, M, Jenkins, B, Gill, C, Wilkinson, P M, Pettengell, R, Radford, J A, Collins, C D, Dexter, T M, Testa, N G, Crowther, D

“…This was the first randomized study to investigate the efficacy of peripheral-blood progenitor cell (PBPC) mobilization using stem-cell factor (SCF) in…”
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The Hematopoietic Defect in Aplastic Anemia Assessed by Long-Term Marrow Culture by Marsh, J.C.W., Chang, J., Testa, N.G., Hows, J.M., Dexter, T.M.

“…Thirty-two patients with aplastic anemia (AA) have been studied using the long-term bone marrow culture (LTBMC) system. Of these patients, 26 had been treated…”
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Myeloid Cell Kinetics in Mice Treated With Recombinant Interleukin-3, Granulocyte Colony-Stimulating Factor (CSF), or Granulocyte-Macrophage CSF In Vivo by Lord, B.I., Molineux, G., Pojda, Z., Souza, L.M., Mermod, J.-J., Dexter, T.M.

“…Myeloid cell kinetics in mice treated with pure hematopoietic growth factors have been investigated using tritiated thymidine labeling and autoradiography…”
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Macrophage-Inflammatory Protein Protects Multipotent Hematopoietic Cells From the Cytotoxic Effects of Hydroxyurea In Vivo by Lord, B.l., Dexter, T.M., Clements, J.M., Hunter, M.A., Gearing, A.J.H.

“…Macrophage inflammatory protein-1 α (MIP-1α) has been assessed for its potential in vivo to protect hematopoietic progenitor cells from the cytotoxic effects…”
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Increased Numbers of Long-Term Culture-Initiating Cells in the Apheresis Product of Patients Randomized to Receive Increasing Doses of Stem Cell Factor Administered in Combination With Chemotherapy and a Standard Dose of Granulocyte Colony-Stimulating Factor by Weaver, A., Ryder, D., Crowther, D., Dexter, T.M., Testa, N.G.

“…Long-term culture-initiating cells (LTC-IC) are arguably the most primitive human hematopoietic cells detectable by in vitro functional assays. We have…”
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Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha by WARK, G, HEYWORTH, C. M, SPOONCER, E, CZAPLEWSKI, L, FRANCIS, J. M, DEXTER, T. M, WHETTON, A. D

“…The clonogenic cells of chronic myeloid leukaemia (CML), unlike normal haemopoietic progenitor cells, are resistant to the growth inhibitory effects of the…”
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