Search Results - "Dewing, Phoebe"

Membrane-initiated estradiol signaling induces spinogenesis required for female sexual receptivity by Christensen, Amy, Dewing, Phoebe, Micevych, Paul

“…Estrogens have profound actions on the structure of the nervous system during development and in adulthood. One of the signature actions of estradiol is to…”
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Direct Regulation of Adult Brain Function by the Male-Specific Factor SRY by Dewing, Phoebe, Chiang, Charleston W.K., Sinchak, Kevin, Sim, Helena, Fernagut, Pierre-Olivier, Kelly, Sabine, Chesselet, Marie-Francoise, Micevych, Paul E., Albrecht, Kenneth H., Harley, Vincent R., Vilain, Eric

“…The central dogma of mammalian brain sexual differentiation has contended that sex steroids of gonadal origin organize the neural circuits of the developing…”
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Estradiol Stimulates Progesterone Synthesis in Hypothalamic Astrocyte Cultures by Micevych, Paul E, Chaban, Victor, Ogi, Julie, Dewing, Phoebe, Lu, John K. H, Sinchak, Kevin

“…The brain synthesizes steroids de novo, especially progesterone. Recently estradiol has been shown to stimulate progesterone synthesis in the hypothalamus and…”
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Membrane-initiated estradiol signaling regulating sexual receptivity by Micevych, Paul E, Dewing, Phoebe

“…Estradiol has profound actions on the structure and function of the nervous system. In addition to nuclear actions that directly modulate gene expression, the…”
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Up-Regulation of WNT-4 Signaling and Dosage-Sensitive Sex Reversal in Humans by Jordan, Brian K., Mohammed, Mansoor, Ching, Saunders T., Délot, Emmanuèle, Chen, Xiao-Ning, Dewing, Phoebe, Swain, Amanda, Rao, P. Nagesh, Elejalde, B. Rafael, Vilain, Eric

“…Wnt-4, a member of the Wnt family of locally acting secreted growth factors, is the first signaling molecule shown to influence the sex-determination cascade…”
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Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation by Dewing, Phoebe, Shi, Tao, Horvath, Steve, Vilain, Eric

“…The classic view of brain sexual differentiation and behavior is that gonadal steroid hormones act directly to promote sex differences in neural and behavioral…”
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Sex differences in hypothalamic astrocyte response to estradiol stimulation by Kuo, John, Hamid, Naheed, Bondar, Galyna, Dewing, Phoebe, Clarkson, Jenny, Micevych, Paul

“…Reproductive functions controlled by the hypothalamus are highly sexually differentiated. One of the most dramatic differences involves estrogen positive…”
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Sexual receptivity is reduced in the female mu-opioid receptor knockout mouse by Sinchak, Kevin, Shahedi, Kamyar, Dewing, Phoebe, Micevych, Paul

“…Activation of μ-opioid receptors is critical to steroid regulation of female sexual behavior, lordosis, in rodents. Estrogen treatment activates μ-opioid…”
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Immediate early gene activity-regulated cytoskeletal-associated protein regulates estradiol-induced lordosis behavior in female rats by Christensen, Amy, Dewing, Phoebe, Micevych, Pavel

“…Sensory feedback is an important component of any behavior, with each instance influencing subsequent activity. Female sexual receptivity is mediated both by…”
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Membrane estrogen receptor-alpha interactions with metabotropic glutamate receptor 1a modulate female sexual receptivity in rats by Dewing, Phoebe, Boulware, Marissa I, Sinchak, Kevin, Christensen, Amy, Mermelstein, Paul G, Micevych, Paul

“…In rats, female sexual behavior is regulated by a well defined limbic-hypothalamic circuit that integrates sensory and hormonal information. Estradiol…”
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Protein Kinase C Signaling in the Hypothalamic Arcuate Nucleus Regulates Sexual Receptivity in Female Rats by Dewing, Phoebe, Christensen, Amy, Bondar, Galyna, Micevych, Paul

“…Rapid membrane-mediated estradiol signaling regulating sexual receptivity requires the interaction of the estrogen receptor (ER)-α and the metabotropic…”
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Membrane-initiated estradiol signaling in immortalized hypothalamic N-38 neurons by Dominguez, Reymundo, Dewing, Phoebe, Kuo, John, Micevych, Paul

“…► Different ERα splice variants are found on the cell surface of N-38 neurons. ► Estradiol increases membrane ERα levels by activation of PKC in N-38 neurons…”
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Modulation of the arcuate nucleus–medial preoptic nucleus lordosis regulating circuit: A role for GABAB receptors by Sinchak, Kevin, Dewing, Phoebe, Ponce, Laura, Gomez, Liliana, Christensen, Amy, Berger, Max, Micevych, Paul

“…Estradiol rapidly activates a microcircuit in the arcuate nucleus of the hypothalamus (ARH) that is needed for maximal female sexual receptivity. Membrane…”
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Dimerization of SOX9 is required for chondrogenesis, but not for sex determination by Bernard, Pascal, Tang, Paisu, Liu, Siyuan, Dewing, Phoebe, Harley, Vincent R., Vilain, Eric

“…The SRY-related SOX9 gene is involved in both chondrogenesis and the early steps of mammalian sex determination. Mutations in the human SOX9 gene cause…”
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Release of orphanin FQ/nociceptin in the medial preoptic nucleus and ventromedial nucleus of the hypothalamus facilitates lordosis by Sinchak, Kevin, Dewing, Phoebe, Cook, Misty, Micevych, Paul

“…Opioid regulation of reproduction has been widely studied. However, the role of opioid receptor-like 1 receptor (NOP; also referred to as ORL-1 and OP4) and…”
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Genetic determinants of mammalian brain sexual differentiation by Dewing, Phoebe

“…The central dogma of brain sexual differentiation asserts that gonadal steroid hormones from the developing embryo acts to promote sex differences in patterns…”
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Genetic determinants of mammalian brain sexual differentiation by Dewing, Phoebe

“…The central dogma of brain sexual differentiation asserts that gonadal steroid hormones from the developing embryo acts to promote sex differences in patterns…”
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Disorders of gonadal development by Dewing, Phoebe, Bernard, Pascal, Vilain, Eric

“…The molecular mechanisms of gonadal development are a complex process, which involves the tightly regulated differentiation of a bipotential embryonic gonad…”
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Membrane Estrogen Receptor-{alpha} Interactions with Metabotropic Glutamate Receptor 1a Modulate Female Sexual Receptivity in Rats by Dewing, Phoebe, Boulware, Marissa I, Sinchak, Kevin, Christensen, Amy, Mermelstein, Paul G, Micevych, Paul

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Midkine Is Expressed Early in Rat Fetal Adrenal Development by Dewing, Phoebe, Ching, Saunders T., Zhang, Yao-Hua, Huang, Bing-Ling, Peirce, Ryan M., McCabe, Edward R.B., Vilain, Eric

“…Adrenal gland development is complex and poorly understood at the molecular level. Only a subset of patients with adrenal hypoplasia congenita (AHC) carry…”
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