Search Results - "Dewhirst, Mark W"

Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress by Dewhirst, Mark W.

“…Dewhirst, M. W. Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress. This Failla Lecture focused on the inter-relationships between…”
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Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response by Dewhirst, Mark W, Cao, Yiting, Moeller, Benjamin

“…Key Points This Review discusses four important and interrelated features of tumour hypoxia: the hypoxic response, the factors that influence tumour hypoxia,…”
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Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis by Sonveaux, Pierre, Copetti, Tamara, De Saedeleer, Christophe J, Végran, Frédérique, Verrax, Julien, Kennedy, Kelly M, Moon, Eui Jung, Dhup, Suveera, Danhier, Pierre, Frérart, Françoise, Gallez, Bernard, Ribeiro, Anthony, Michiels, Carine, Dewhirst, Mark W, Feron, Olivier

“…Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue…”
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Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise by Betof, Allison S, Lascola, Christopher D, Weitzel, Douglas, Landon, Chelsea, Scarbrough, Peter M, Devi, Gayathri R, Palmer, Gregory, Jones, Lee W, Dewhirst, Mark W

“…Exercise has been shown to improve postischemia perfusion of normal tissues; we investigated whether these effects extend to solid tumors. Estrogen…”
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Announcement of leadership transition by Dewhirst, Mark W, Dewhirst, Nancy J

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CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels? by van Rhoon, Gerard C., Samaras, Theodoros, Yarmolenko, Pavel S., Dewhirst, Mark W., Neufeld, Esra, Kuster, Niels

“…Objective To define thresholds of safe local temperature increases for MR equipment that exposes patients to radiofrequency fields of high intensities for long…”
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Editors’ awardees for 2023 by Dewhirst, Mark W.

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Imaging tumor hypoxia to advance radiation oncology by Lee, Chen-Ting, Boss, Mary-Keara, Dewhirst, Mark W

“…Most solid tumors contain regions of low oxygenation or hypoxia. Tumor hypoxia has been associated with a poor clinical outcome and plays a critical role in…”
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Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation by Kennedy, Kelly M, Dewhirst, Mark W

“…Tumor metabolism consists of complex interactions between oxygenation states, metabolites, ions, the vascular network and signaling cascades. Accumulation of…”
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Thresholds for thermal damage to normal tissues: an update by Yarmolenko, Pavel S, Moon, Eui Jung, Landon, Chelsea, Manzoor, Ashley, Hochman, Daryl W, Viglianti, Benjamin L, Dewhirst, Mark W

“…The purpose of this review is to summarise a literature survey on thermal thresholds for tissue damage. This review covers published literature for the…”
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Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment by Moeller, Benjamin J, Richardson, Rachel A, Dewhirst, Mark W

“…A large body of clinical evidence exists to suggest that tumor hypoxia negatively impacts radiotherapy. As a result, there has been longstanding active…”
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ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer by Park, Sunghee, Chang, Ching-Yi, Safi, Rachid, Liu, Xiaojing, Baldi, Robert, Jasper, Jeff S., Anderson, Grace R., Liu, Tingyu, Rathmell, Jeffrey C., Dewhirst, Mark W., Wood, Kris C., Locasale, Jason W., McDonnell, Donald P.

“…Imaging studies in animals and in humans have indicated that the oxygenation and nutritional status of solid tumors is dynamic. Furthermore, the extremely low…”
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Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting by DEWHIRST, Mark W

“…Hypoxia-inducible factor-1 (HIF-1) stabilization is a pivotal event in the response to hypoxic stress. A study in the December 15, 2006 issue of Cancer…”
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The future of biology in driving the field of hyperthermia by Dewhirst, Mark W, Lee, Chen-Ting, Ashcraft, Kathleen A

“…In 2011 Hanahan and Weinberg updated their well-established paper 'The hallmarks of cancer'. The rationale for that review and its predecessor was to produce a…”
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Regulation of HIF-1α Stability through S-Nitrosylation by Li, Fang, Sonveaux, Pierre, Rabbani, Zahid N., Liu, Shanling, Yan, Bin, Huang, Qian, Vujaskovic, Zeljko, Dewhirst, Mark W., Li, Chuan-Yuan

“…Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional factor. Under normal oxygen tension, HIF-1 activity is usually suppressed due to the rapid,…”
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Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer by Kennedy, Kelly M, Scarbrough, Peter M, Ribeiro, Anthony, Richardson, Rachel, Yuan, Hong, Sonveaux, Pierre, Landon, Chelsea D, Chi, Jen-Tsan, Pizzo, Salvatore, Schroeder, Thies, Dewhirst, Mark W

“…Lactate accumulation in tumors has been associated with metastases and poor overall survival in cancer patients. Lactate promotes angiogenesis and metastasis,…”
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Angiogenesis: an adaptive dynamic biological patterning problem by Secomb, Timothy W, Alberding, Jonathan P, Hsu, Richard, Dewhirst, Mark W, Pries, Axel R

“…Formation of functionally adequate vascular networks by angiogenesis presents a problem in biological patterning. Generated without predetermined spatial…”
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In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters by Palmer, Gregory M, Fontanella, Andrew N, Shan, Siqing, Hanna, Gabi, Zhang, Guoqing, Fraser, Cassandra L, Dewhirst, Mark W

“…Optical techniques for functional imaging in mice have a number of key advantages over other common imaging modalities such as magnetic resonance imaging,…”
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Implications of Increase in Vascular Permeability in Tumors by VEGF: A Commentary on the Pioneering Work of Harold Dvorak by Dewhirst, Mark W, Ashcraft, Kathleen A

“…See related article by Senger et al., Cancer Res 1986;46:5629-32Visit the Cancer Research 75(th) Anniversary timeline…”
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Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials by Coleman, C Norman, Higgins, Geoff S, Brown, J Martin, Baumann, Michael, Kirsch, David G, Willers, Henning, Prasanna, Pataje G S, Dewhirst, Mark W, Bernhard, Eric J, Ahmed, Mansoor M

“…There is an urgent need to improve reproducibility and translatability of preclinical data to fully exploit opportunities for molecular therapeutics involving…”
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