Search Results - "Dewar, K M"

Effects of denervation and hyperinnervation on dopamine and serotonin systems in the rat neostriatum : implications for human Parkinson's disease by READER, T. A, DEWAR, K. M

“…The research on central synaptic neurotransmission has greatly benefited from the use of the neurotoxin 2,4,5-trihydroxyphenylethylamine, or 6-hydroxydopamine…”
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The quest for biological correlates of social phobia: an interim assessment by Dewar, K. M., Stravynski, A.

“…Objective: The primary goal of this review was to assess critically the literature concerning the ongoing search for possible biological correlates of social…”
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Altered dopamine and serotonin metabolism in the dopamine-denervated and serotonin-hyperinnervated neostriatum of adult rat after neonatal 6-hydroxydopamine by Molina-Holgado, E, Dewar, K M, Descarries, L, Reader, T A

“…3,4-Dihydroxyphenylalanine (L-DOPA), 5-hydroxy-l-tryptophan (5-HTP), dopamine (DA), 5-hydroxytryptamine (5-HT) and their metabolites were measured in the…”
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Changes of D1 and D2 receptors in adult rat neostriatum after neonatal dopamine denervation: quantitative data from ligand binding, in situ hybridization and iontophoresis by Radja, F, el Mansari, M, Soghomonian, J J, Dewar, K M, Ferron, A, Reader, T A, Descarries, L

“…The specific binding of [3H]SCH23390 to D1 and of [3H]raclopride to D2 dopamine receptors was measured by autoradiography in the rostral and caudal halves of…”
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Elevation of dopamine D2 but not D1 receptors in adult rat neostriatum after neonatal 6-hydroxydopamine denervation by Dewar, K M, Soghomonian, J J, Bruno, J P, Descarries, L, Reader, T A

“…Monoamine levels and the binding properties of [3H]SCH23390, a D1-specific ligand, and [3H]raclopride, a D2-specific ligand, were measured in the rostal and…”
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Apparent dopamine D1 and D2 receptors in the weaver mutant mouse : receptor binding and coupling to adenylyl cyclase by DEWAR, K. M, PAQUET, M, SEQUEIRA, A

“…Weaver mutant mice have a selective degeneration of the nigrostriatal dopamine pathway arising between 7-21 days after birth. The goal of this study was to…”
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Alterations in serotonin receptors in the neostriatum of weaver mutant mice by DEWAR, K. M

“…Mice that carry the autosomal recessive gene weaver show a distinctive loss of nigrostriatal dopamine innervation, with the greatest deficits in the dorsal…”
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Interaction between dopamine and glutamate receptors following treatment with NMDA receptor antagonists by Vasiliadis, Helen-Maria, Élie, Robert, Dewar, Karen M

“…Interactions between dopamine and glutamate neurotransmission have been reported to play an important role in a number of different systems. We were interested…”
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Dopamine D2 receptors labeled with [3H]raclopride in rat and rabbit brains. Equilibrium binding, kinetics, distribution and selectivity by Dewar, K M, Montreuil, B, Grondin, L, Reader, T A

“…The binding properties of the substituted benzamide raclopride to dopamine D2 receptors were studied with membrane preparations from rat and rabbit…”
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Alterations in the turnover rate of dopamine D1 but not D2 receptors in the adult rat neostriatum after a neonatal dopamine denervation by Dewar, Karen M, Paquet, Maryse, Reader, Tomás A

“…Adult rats that were treated with intracerebral ventricular injection of 6-hydroxydopamine (6-OHDA) as neonates exhibit a profound loss of nigrostriatal…”
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Changes of amino acid and monoamine levels after neonatal 6-hydroxydopamine denervation in rat basal ganglia, substantia nigra, and Raphe nuclei by Molina-Holgado, E, Dewar, K M, Grondin, L, van Gelder, N M, Reader, T A

“…The effects of a neonatal dopaminergic deafferentation with the neurotoxin 6-hydroxydopamine (6-OHDA) on endogenous tissue levels of catecholamines,…”
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[3H]paroxetine binding and serotonin content of rat brain: absence of changes following antidepressant treatments by Dewar, K M, Grondin, L, Nénonéné, E K, Ohayon, M, Reader, T A

“…The high affinity binding of [3H]paroxetine was measured in rat cerebral cortex following chronic treatment (21 days) with imipramine (5 mg/kg), trimipramine…”
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Effects of chronic lithium treatments on central dopaminergic receptor systems: G proteins as possible targets by Carli, M, Anand-Srivastava, M B, Molina-Holgado, E, Dewar, K M, Reader, T A

“…Numerous biochemical and electrophysiological studies have proposed a role for dopamine (DA) in the therapeutic efficacy of lithium (Li+) salts. The effects of…”
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Amino acid levels and gamma-aminobutyric acidA receptors in rat neostriatum, cortex, and thalamus after neonatal 6-hydroxydopamine lesion by Molina-Holgado, E, Dewar, K M, Grondin, L, van Gelder, N M, Reader, T A

“…The amino acid gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in brain, and GABAergic neurons have been proposed to play a major role…”
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Dopamine receptor alterations correlate with increased GABA levels in adult rat neostriatum : effects of a neonatal 6-hydroxydopamine denervation by Molina-Holgado, Eduardo, Van Gelder, Nico M., Dewar, Karen M., Reader, Tomás A.

“…The effects of neonatal intracerebroventricular 6-hydroxydopamine (6-OHDA) injection on the densities of dopamine (DA) receptors and GABA levels were…”
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Distribution, morphology and habenular projections of adenosine deaminase-containing neurons in the septal area of rat by Staines, W A, Yamamoto, T, Dewar, K M, Daddona, P E, Geiger, J D, Nagy, J I

“…Adenosine deaminase (ADA) was localized within several types of neurons within the septum and in septal efferent projections to the habenula by…”
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Specific [3H]SCH23390 binding to dopamine D1 receptors in cerebral cortex and neostriatum: role of disulfide and sulfhydryl groups by Dewar, K M, Reader, T A

“…Receptor binding studies were performed in cerebral cortex (CTX) and neostriatum (CPU; caudate-putamen) using the dopamine D1 antagonist [3H]SCH23390. Because…”
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Effects of monovalent cations on neostriatal dopamine D2 receptors labeled with [3H]raclopride by Reader, T A, Boulianne, S, Molina-Holgado, E, Dewar, K M

“…Specific [3H]raclopride binding to dopamine D2 receptors in the rabbit neostriatum was investigated in the presence of the monovalent cations sodium, lithium…”
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Distribution of monoamines and metabolites in rabbit neostriatum, hippocampus and cortex by Reader, T A, Dewar, K M, Grondin, L

“…The monoamines noradrenaline (NA), dopamine (DA), adrenaline (AD) and 5-hydroxytryptamine (5-HT) were assayed in the putamen (PUT), the lateral (lCAU) and…”
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Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study by Radja, F, Descarries, L, Dewar, K M, Reader, T A

“…Neonatal destruction of nigrostriatal dopamine neurons by cerebroventricular injection of 6-hydroxydopamine (6-OHDA) results in a serotonin (5-HT)…”
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