Search Results - "Dewar, Brian J."

A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing by Mousley, Carl J., Yuan, Peihua, Gaur, Naseem A., Trettin, Kyle D., Nile, Aaron H., Deminoff, Stephen J., Dewar, Brian J., Wolpert, Max, Macdonald, Jeffrey M., Herman, Paul K., Hinnebusch, Alan G., Bankaitis, Vytas A.

“…Kes1, and other oxysterol-binding protein superfamily members, are involved in membrane and lipid trafficking through trans-Golgi network (TGN) and endosomal…”
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Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia by Cooper, Matthew J, Cox, Nathan J, Zimmerman, Eric I, Dewar, Brian J, Duncan, James S, Whittle, Martin C, Nguyen, Thien A, Jones, Lauren S, Ghose Roy, Sreerupa, Smalley, David M, Kuan, Pei Fen, Richards, Kristy L, Christopherson, Richard I, Jin, Jian, Frye, Stephen V, Johnson, Gary L, Baldwin, Albert S, Graves, Lee M

“…Protein kinases play key roles in oncogenic signaling and are a major focus in the development of targeted cancer therapies. Imatinib, a BCR-Abl tyrosine…”
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Src-mediated phosphorylation of the tyrosine phosphatase PRL-3 is required for PRL-3 promotion of Rho activation, motility and invasion by Fiordalisi, James J, Dewar, Brian J, Graves, Lee M, Madigan, James P, Cox, Adrienne D

“…The metastasis-associated tyrosine phosphatase PRL-3/PTP4A is upregulated in numerous cancers, but the mechanisms modulating PRL-3 activity other than its…”
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Activation of mitogen-activated protein kinases by peroxisome proliferator-activated receptor ligands: an example of nongenomic signaling by Gardner, Olivia S, Dewar, Brian J, Graves, Lee M

“…Peroxisome proliferator-activated receptors (PPARs) are a subfamily of nuclear hormone receptors that function as ligand-activated transcription factors to…”
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Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation by Madigan, James P, Bodemann, Brian O, Brady, Donita C, Dewar, Brian J, Keller, Patricia J, Leitges, Michael, Philips, Mark R, Ridley, Anne J, Der, Channing J, Cox, Adrienne D

“…The Rnd proteins (Rnd1, Rnd2 and Rnd3/RhoE) form a distinct branch of the Rho family of small GTPases. Altered Rnd3 expression causes changes in cytoskeletal…”
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Regulation of the Rho Family Small GTPase Wrch-1/RhoU by C-Terminal Tyrosine Phosphorylation Requires Src by Alan, Jamie K., Berzat, Anastacia C., Dewar, Brian J., Graves, Lee M., Cox, Adrienne D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption by Eaton, Michael S., Weinstein, Nicholas, Newby, Jordan B., Plattes, Maggie M., Foster, Hanna E., Arthur, Jon W., Ward, Taylor D., Shively, Stephen R., Shor, Ryann, Nathan, Justin, Davis, Hannah M., Plotkin, Lilian I., Wauson, Eric M., Dewar, Brian J., Broege, Aaron, Lowery, Jonathan W.

“…The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3…”
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Dependence of Peroxisome Proliferator-activated Receptor Ligand-induced Mitogen-activated Protein Kinase Signaling on Epidermal Growth Factor Receptor Transactivation by Gardner, Olivia S., Dewar, Brian J., Earp, H. Shelton, Samet, James M., Graves, Lee M.

“…Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that function as ligand-activated transcription factors regulating lipid…”
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Capacitative calcium entry contributes to the differential transactivation of the epidermal growth factor receptor in response to thiazolidinediones by Dewar, Brian J, Gardner, Olivia S, Chen, Ching-Shih, Earp, H Shelton, Samet, James M, Graves, Lee M

“…Thiazolidinediones (TZDs) are synthetic ligands for the peroxisome proliferator-activated receptor gamma (PPARgamma) but also elicit PPARgamma-independent…”
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Hyperpolarized 13C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism by Keshari, Kayvan R., Kurhanewicz, John, Jeffries, Rex E., Wilson, David M., Dewar, Brian J., Van Criekinge, Mark, Zierhut, Matthew, Vigneron, Daniel B., Macdonald, Jeffrey M.

“…The purpose of this study was to combine a three‐dimensional NMR‐compatible bioreactor with hyperpolarized 13C NMR spectroscopy in order to probe cellular…”
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Lyn regulates creatine uptake in an imatinib-resistant CML cell line by Okumu, Denis O., Aponte-Collazo, Lucas J., Dewar, Brian J., Cox, Nathan J., East, Michael P., Tech, Katherine, McDonald, Ian M., Tikunov, Andrey P., Holmuhamedov, Ekhson, Macdonald, Jeffrey M., Graves, Lee M.

“…Imatinib mesylate (imatinib) is the first-line treatment for newly diagnosed chronic myeloid leukemia (CML) due to its remarkable hematologic and cytogenetic…”
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Nicotine increases hepatic oxygen uptake in the isolated perfused rat liver by inhibiting glycolysis by Dewar, Brian J, Bradford, Blair U, Thurman, Ronald G

“…Nicotine influences energy metabolism, yet mechanisms remain unclear. Since the liver is one of the largest organs and performs many metabolic functions, the…”
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Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism by Keshari, Kayvan R, Kurhanewicz, John, Jeffries, Rex E, Wilson, David M, Dewar, Brian J, Van Criekinge, Mark, Zierhut, Matthew, Vigneron, Daniel B, Macdonald, Jeffrey M

“…The purpose of this study was to combine a three-dimensional NMR-compatible bioreactor with hyperpolarized (13)C NMR spectroscopy in order to probe cellular…”
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Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor by Samet, James M, Dewar, Brian J, Wu, Weidong, Graves, Lee M

“…Zn(2+) is a ubiquitous ambient air contaminant that is found as a constituent of airborne particulate matter (PM). Previous studies have associated Zn(2+)…”
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Metabolic assessment of a novel chronic myelogenous leukemic cell line and an imatinib resistant subline by H NMR spectroscopy by Dewar, Brian J, Keshari, Kayvan, Jeffries, Rex, Dzeja, Petras, Graves, Lee M, Macdonald, Jeffrey M

“…The goal of this study was to examine metabolic differences between a novel chronic myelogenous leukemic (CML) cell line, MyL, and a sub-clone, MyL-R, which…”
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Metabolic assessment of a novel chronic myelogenous leukemic cell line and an imatinib resistant subline by ¹H NMR spectroscopy by Dewar, Brian J, Keshari, Kayvan, Jeffries, Rex, Dzeja, Petras, Graves, Lee M, Macdonald, Jeffrey M

“…The goal of this study was to examine metabolic differences between a novel chronic myelogenous leukemic (CML) cell line, MyL, and a sub-clone, MyL-R, which…”
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Profiling the Kinome of Drug Resistant Chronic Myelogenous Leukemia by Cox, Nathan James, Zimmerman, Eric I., Dewar, Brian J., Duncan, James, Whittle, Marty, Jin, Jian, Frye, Stephen V., Johnson, Gary L., Graves, Lee M.

“…Kinases compose only two percent of the human genome; however, they represent some of the potentially most important new drug targets for cancer chemotherapy…”
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Mechanisms of Zn2+-induced signal initiation through the epidermal growth factor receptor by SAMET, James M, DEWAR, Brian J, WEIDONG WU, GRAVES, Lee M

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High Throughput Screening of Biosensor Domains: Visualizing Dynamic Activation of Src Kinases in Live Cells by Gulyani, Akash, Vitriol, Eric, Gremyachinskiy, Dmitriy, Dewar, Brian J., Nguyen, Alan, Graves, Lee M., Kay, Brian K., Hahn, Klaus M.

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Hyperpolarized 13 C spectroscopy and an NMR‐compatible bioreactor system for the investigation of real‐time cellular metabolism by Keshari, Kayvan R., Kurhanewicz, John, Jeffries, Rex E., Wilson, David M., Dewar, Brian J., Van Criekinge, Mark, Zierhut, Matthew, Vigneron, Daniel B., Macdonald, Jeffrey M.

“…The purpose of this study was to combine a three‐dimensional NMR‐compatible bioreactor with hyperpolarized 13 C NMR spectroscopy in order to probe cellular…”
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