Search Results - "Devos, Rene"

Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator by Zalachoras, Ioannis, Houtman, René, Atucha, Erika, Devos, Rene, Tijssen, Ans M. I., Hu, Pu, Lockey, Peter M., Datson, Nicole A., Belanoff, Joseph K., Lucassen, Paul J., Joëls, Marian, de Kloet, E. Ronald, Roozendaal, Benno, Hunt, Hazel, Meijer, Onno C.

“…Glucocorticoid receptor (GR) antagonism may be of considerable therapeutic value in stress-related psychopathology such as depression. However, blockade of all…”
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The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture by Klumpp, Klaus, Lévêque, Vincent, Le Pogam, Sophie, Ma, Han, Jiang, Wen-Rong, Kang, Hyunsoon, Granycome, Caroline, Singer, Margaret, Laxton, Carl, Hang, Julie Qi, Sarma, Keshab, Smith, David B., Heindl, Dieter, Hobbs, Chris J., Merrett, John H., Symons, Julian, Cammack, Nick, Martin, Joseph A., Devos, Rene, Nájera, Isabel

“…Hepatitis C virus (HCV) polymerase activity is essential for HCV replication. Targeted screening of nucleoside analogs identified R1479 (4′-azidocytidine) as a…”
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Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks by Campfield, L.A. (Hoffmann-La Roche Incorporated, Nutley, NJ.), Smith, F.J, Guisez, Y, Devos, R, Burn, P

“…The recent positional cloning of the mouse ob gene and its human homolog has provide the basis to investigate the potential role of the ob gene product in body…”
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Identification and expression cloning of a leptin receptor, OB-R by Tartaglia, Louis A., Dembski, Marlene, Weng, Xun, Deng, Nanhua, Culpepper, Janice, Devos, Rene, Richards, Grayson J., Campfield, L.Arthur, Clark, Frederick T., Deeds, Jim, Muir, Craig, Sanker, Sean, Moriarty, Ann, Moore, Karen J., Smutko, John S., Mays, Gail G., Wool, Elizabeth A., Monroe, Cheryl A., Tepper, Robert I.

“…The ob gene product, leptin, is an important circulating signal for the regulation of body weight. To identify high affinity leptin-binding sites, we generated…”
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Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators by Ray, Nicholas C., Clark, Robin D., Clark, David E., Williams, Karen, Hickin, H.G., Crackett, Peter H., Dyke, Hazel J., Lockey, Peter M., Wong, Melanie, Devos, René, White, Anne, Belanoff, Joseph K.

“…A virtual screening approach followed by lead optimization led to a series of compounds, exemplified by 12, that were potent, selective GR antagonists. A…”
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Role of IFN-gamma in the Inhibition of the Allergic Airway Inflammation Caused by IL-12 by Brusselle, Guy G, Kips, Johan C, Peleman, Renaat A, Joos, Guy F, Devos, Rene R, Tavernier, Jan H, Pauwels, Romain A

“…T-helper 2 (Th2)-like cells are thought to play a crucial role in the pathogenesis of the eosinophilic airway inflammation observed in asthma. In a murine…”
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Leptin Receptor (OB-R) Signaling by White, David W., Kuropatwinski, Karen K., Devos, Rene, Baumann, Heinz, Tartaglia, Louis A.

“…The leptin receptor (OB-R) mediates the weight regulatory effects of the adipocyte secreted hormone leptin (OB). Previously we have shown that the long form of…”
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Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding by Devos, René, Guisez, Yves, Van der Heyden, José, White, David W., Kalai, Michael, Fountoulakis, Michael, Plaetinck, Geert

“…The leptin receptor is a class I transmembrane protein with either a short or a long cytoplasmic domain. Using chemical cross-linking we have analyzed the…”
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Abstract 5137: Parallel approaches to the discovery of novel BRD4 inhibitors by Jones, David H., Groot, Marcel J. de, Heald, Robert, Arhin, Ebenezer, Goodwin, Ria, Burton, Brenda, Kulagowski, Jan, Brown, David, Irving, Steven, Bazin, Richard, Bruce, Deborah, Devos, Rene, Price, Steven, Ray, Nick, Lockey, Peter, Montana, John, Albertella, Mark R., Green, Simon R.

“…Abstract Epigenetic signalling is essential for the regulation of gene expression and cellular development, and disruption of these pathways has been…”
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Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479 by Smith, David B., Martin, Joseph A., Klumpp, Klaus, Baker, Stewart J., Blomgren, Peter A., Devos, Rene, Granycome, Caroline, Hang, Julie, Hobbs, Christopher J., Jiang, Wen-Rong, Laxton, Carl, Pogam, Sophie Le, Leveque, Vincent, Ma, Han, Maile, Graham, Merrett, John H., Pichota, Arkadius, Sarma, Keshab, Smith, Mark, Swallow, Steven, Symons, Julian, Vesey, David, Najera, Isabel, Cammack, Nick

“…The synthesis of 4′-substituted nucleosides as potential antiviral agents is reported. A series of 4′-substituted ribonucleoside derivatives has been prepared…”
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High-level expression of human interferon gamma in Escherichia coli under control of the pL promoter of bacteriophage lambda by Simons, G, Remaut, E, Allet, B, Devos, R, Fiers, W

“…Several recombinant plasmids have been constructed which direct high-level synthesis of mature human interferon gamma (IFN-gamma) in Escherichia coli using the…”
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1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity by CLARK, Robin D, RAY, Nicholas C, DEVOS, Rene, WONG, Melanie, PORRES, Soraya S, BRIGHT, Colin P, JENKINS, Robert E, BELANOFF, Joseph, WILLIAMS, Karen, BLANEY, Paul, WARD, Stuart, CRACKETT, Peter H, HURLEY, Christopher, DYKE, Hazel J, CLARK, David E, LOCKEY, Peter

“…Addition of the 4-fluorophenylpyrazole group to the previously described 2-azadecalin glucocorticoid receptor (GR) antagonist 1 resulted in significantly…”
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Leptin receptor (OB-R) signaling: cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization by White, D.W. (Millennium Pharmaceuticals, Cambridge, MA.), Kuropatwinski, K.K, Devos, R, Baumann, H, Tartaglia, L.A

“…The leptin receptor (OB-R) mediates the weight regulatory effects of the adipocyte secreted hormone leptin (OB). Previously we have shown that the long form of…”
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A human leptin mutant induces weight gain in normal mice by Verploegen, Sandra A.B.W., Plaetinck, Geert, Devos, René, Van der Heyden, José, Guisez, Yves

“…Leptin, a fat secreted hormone, regulates ingestive behaviour and energy balance by binding to a specific receptor. Using site-directed mutagenesis, we…”
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64 The discovery of leptin and the leptin receptor: Perspectives for the treatment of obesity and wasting disorders by Devos, Rene

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Comparison of R128Q Mutations in Human, Ovine, and Chicken Leptins by Raver, Nina, Vardy, Eyal, Livnah, Oded, Devos, Rene, Gertler, Arieh

“…Human leptin and its R128Q mutant, as well as the R128Q mutants of ovine and chicken leptins, were prepared, expressed in Escherichia coli, refolded, and…”
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2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists by Clark, Robin D., Ray, Nicholas C., Blaney, Paul, Crackett, Peter H., Hurley, Christopher, Williams, Karen, Dyke, Hazel J., Clark, David E., Lockey, Peter M., Devos, Rene, Wong, Melanie, White, Anne, Belanoff, Joseph K.

“…The synthesis and glucocorticoid receptor (GR) binding and functional antagonist activity of a series of substituted 2-azadecalins is reported. ( R )- 37 was…”
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Structural studies of the carbohydrate chains of human γ‐interferon by MUTSAERS, Johanna H. G. M., KAMERLING, Johannis P., DEVOS, Rene, GUISEZ, Yves, FIERS, Walter, VLIEGENTHART, Johannes F. G.

“…Human γ‐interferon (IFN‐γ) was prepared biotechnologically using Chinese hamster ovary cells. These cells were shown to be able to produce glycosylated IFN‐γ…”
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1 H-Pyrazolo[3,4- g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity by Clark, Robin D., Ray, Nicholas C., Williams, Karen, Blaney, Paul, Ward, Stuart, Crackett, Peter H., Hurley, Christopher, Dyke, Hazel J., Clark, David E., Lockey, Peter, Devos, Rene, Wong, Melanie, Porres, Soraya S., Bright, Colin P., Jenkins, Robert E., Belanoff, Joseph

“…Fusion of the 4-fluorophenylpyrazole group onto the azadecalin system afforded high affinity glucocorticoid receptor (GR) antagonists. The bridgehead position…”
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OB protein binds specifically to the choroid plexus of mice and rats by Devos, R. (Roche Research Gent, Gent, Belgium.), Richards, J.G, Campfield, L.A, Tartaglia, L.A, Guisez, Y, Heyden, J. van der, Travernier, J, Plaetinck, G, Burn, P

“…Binding studies were conducted to identify the anatomical location of brain target sites for OB protein, the ob gene product. 125I-labeled recombinant mouse OB…”
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