Search Results - "Devlin, Garth W."
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The membrane associated accessory protein is an adeno-associated viral egress factor
Published in Nature communications (29-10-2021)“…Adeno-associated viruses (AAV) rely on helper viruses to transition from latency to lytic infection. Some AAV serotypes are secreted in a pre-lytic manner as…”
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Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing
Published in Nature communications (10-10-2022)“…Recombinant adeno-associated viral (AAV) vectors are a promising gene delivery platform, but ongoing clinical trials continue to highlight a relatively narrow…”
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Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses
Published in Journal of virology (01-06-2019)“…Central nervous system (CNS) transduction by systemically administered recombinant adeno-associated viral (AAV) vectors requires crossing the blood-brain…”
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Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts
Published in Frontiers in cardiovascular medicine (10-02-2022)“…The optimal delivery route to enhance effectiveness of regenerative therapeutics to the human heart is poorly understood. Direct intra-myocardial (IM)…”
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Evaluation of AAV Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy
Published in Translational stroke research (08-07-2024)“…Nosebleeds and intracranial hemorrhage from brain arteriovenous malformations (bAVMs) are among the most devastating symptoms of patients with hereditary…”
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Deep Learning Resolves Myovascular Dynamics in the Failing Human Heart
Published in JACC. Basic to translational science (01-05-2024)“…The adult mammalian heart harbors minute levels of cycling cardiomyocytes (CMs). Large numbers of images are needed to accurately quantify cycling events using…”
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739 TREATMENT OF CYSTIC FIBROSIS WITH IN VIVO BASE EDITING OF THE INTESTINAL EPITHELIUM
Published in Gastroenterology (New York, N.Y. 1943) (01-05-2023)Get full text
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