Search Results - "Devlin, Blythe H."

Thymic microenvironment reconstitution after postnatal human thymus transplantation by Li, Bin, Li, Jie, Devlin, Blythe H, Markert, M. Louise

“…Abstract A functional thymus develops after cultured thymus tissue is transplanted into subjects with complete DiGeorge anomaly. To gain insight into how the…”
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Thymus transplantation in complete DiGeorge anomaly by Markert, M. Louise, Devlin, Blythe H., Chinn, Ivan K., McCarthy, Elizabeth A.

“…Complete DiGeorge anomaly is characterized by athymia, congenital heart disease, and hypoparathyroidism. This congenital disease is fatal by age 2 years unless…”
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Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation by Albuquerque, Adriana S, Marques, José G, Silva, Susana L, Ligeiro, Dario, Devlin, Blythe H, Dutrieux, Jacques, Cheynier, Rémi, Pignata, Claudio, Victorino, Rui M M, Markert, M Louise, Sousa, Ana E

“…Forkhead box N1 (FOXN1) is a transcription factor crucial for thymic epithelium development and prevention of its involution. Investigation of a patient with a…”
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The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly by Ciupe, Stanca M, Devlin, Blythe H, Markert, M Louise, Kepler, Thomas B

“…T cell populations are regulated both by signals specific to the T-cell receptor (TCR) and by signals and resources, such as cytokines and space, that act…”
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Thymus transplantation by Markert, M. Louise, Devlin, Blythe H, McCarthy, Elizabeth A

“…Abstract Thymus transplantation is a promising investigational therapy for infants born with no thymus. Because of the athymia, these infants lack T cell…”
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Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation by Chinn, Ivan K., MD, Olson, John A., MD, PhD, Skinner, Michael A., MD, McCarthy, Elizabeth A., RN, CCRP, Gupton, Stephanie E., RN, CPNP, Chen, Dong-Feng, PhD, Bonilla, Francisco A., MD, PhD, Roberts, Robert L., MD, PhD, Kanariou, Maria G., MD, Devlin, Blythe H., PhD, Markert, M. Louise, MD, PhD

“…Background The induction of tolerance toward third-party solid organ grafts with allogeneic thymus tissue transplantation has not been previously demonstrated…”
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First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases by Markert, M. Louise, Marques, José G., Neven, Bénédicte, Devlin, Blythe H., McCarthy, Elizabeth A., Chinn, Ivan K., Albuquerque, Adriana S., Silva, Susana L., Pignata, Claudio, de Saint Basile, Geneviève, Victorino, Rui M., Picard, Capucine, Debre, Marianne, Mahlaoui, Nizar, Fischer, Alain, Sousa, Ana E.

“…FOXN1 deficiency is a primary immunodeficiency characterized by athymia, alopecia totalis, and nail dystrophy. Two infants with FOXN1 deficiency were…”
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Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants by Markert, M. Louise, Devlin, Blythe H., Alexieff, Marilyn J., Li, Jie, McCarthy, Elizabeth A., Gupton, Stephanie E., Chinn, Ivan K., Hale, Laura P., Kepler, Thomas B., He, Min, Sarzotti, Marcella, Skinner, Michael A., Rice, Henry E., Hoehner, Jeffrey C.

“…The purpose of this study was to characterize a large group of infants with complete DiGeorge anomaly and to evaluate the ability of thymus transplantation to…”
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Quantification of total T-cell receptor diversity by flow cytometry and spectratyping by Ciupe, Stanca M, Devlin, Blythe H, Markert, Mary Louise, Kepler, Thomas B

“…T-cell receptor diversity correlates with immune competency and is of particular interest in patients undergoing immune reconstitution. Spectratyping generates…”
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Complete DiGeorge syndrome: Development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases by Louise Markert, M, Alexieff, Marilyn J, Li, Jie, Sarzotti, Marcella, Ozaki, Daniel A, Devlin, Blythe H, Sempowski, Gregory D, Rhein, Maria E, Szabolcs, Paul, Hale, Laura P, Buckley, Rebecca H, Coyne, Katharine E, Rice, Henry E, Mahaffey, Samuel M, Skinner, Michael A

“…Five patients with DiGeorge syndrome presented with infections, skin rashes, and lymphadenopathy after the newborn period. T-cell counts and function varied…”
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Diagnosis of 22q11.2 Deletion Syndrome and Artemis Deficiency in Two Children with T-B-NK+ Immunodeficiency by Heimall, Jennifer, Keller, Michael, Saltzman, Rushani, Bunin, Nancy, McDonald-McGinn, Donna, Zakai, Elaine, de Villartay, Jean-Pierre, Moshous, Despina, Ariue, Barbara, McCarthy, Elizabeth A., Devlin, Blythe H., Parikh, Suhag, Buckley, Rebecca H., Markert, M. Louise

“…Two infants are described who presented with 22q11.2 deletion and a T - B - NK + immune phenotype. For both infants, the initial diagnosis was athymia…”
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Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome by Markert, M. Louise, Alexieff, Marilyn J., Li, Jie, Sarzotti, Marcella, Ozaki, Daniel A., Devlin, Blythe H., Sedlak, Debra A., Sempowski, Gregory D., Hale, Laura P., Rice, Henry E., Mahaffey, Samuel M., Skinner, Michael A.

“…Complete DiGeorge syndrome is a fatal congenital disorder characterized by athymia, hypoparathyroidism, and heart defects. Less than half of patients are 22q11…”
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Use of Allograft Biopsies to Assess Thymopoiesis after Thymus Transplantation by Markert, M. Louise, Li, Jie, Devlin, BlyH, Hoehner, Jeffrey C, Rice, Henry E, Skinner, Michael A, Li, Yi-Ju, Hale, Laura P

“…Thymus allograft biopsies were performed in athymic infants with complete DiGeorge anomaly after thymus transplantation to assess whether the thymus allograft…”
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Long-term tolerance to allogeneic thymus transplants in complete DiGeorge anomaly by Chinn, Ivan K, Devlin, Blythe H, Li, Yi-Ju, Markert, M. Louise

“…Abstract Thymus transplantation in subjects with complete DiGeorge anomaly using postnatal allogeneic HLA-nonmatched cultured thymus tissue provides…”
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Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection by Hudson, Lori L, Louise Markert, M, Devlin, Blythe H, Haynes, Barton F, Sempowski, Gregory D

“…Abstract The thymus is essential for proper development and maintenance of a broad T cell repertoire capable of recognizing a wide-range of foreign antigens…”
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Characterization of cultured thymus tissue used for transplantation with emphasis on promiscuous expression of thyroid tissue-specific genes by Li, Bin, Li, Jie, Hsieh, Chia-San, Hale, Laura P., Li, Yi-Ju, Devlin, Blythe H., Markert, M. Louise

“…Autoimmune thyroid disease occurs in some complete DiGeorge anomaly patients after thymus transplantation. This study was designed to assess the effect of…”
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Statistical analysis of antigen receptor spectratype data by Kepler, Thomas B., He, Min, Tomfohr, John K., Devlin, Blythe H., Sarzotti, Marcella, Markert, M. Louise

“…Motivation: The effectiveness of vertebrate adaptive immunity depends crucially on the establishment and maintenance of extreme diversity in the antigen…”
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SpA: web-accessible spectratype analysis: data management, statistical analysis and visualization by He, Min, Tomfohr, John K., Devlin, Blythe H., Sarzotti, Marcella, Markert, M. Louise, Kepler, Thomas B.

“…SpA is a web-accessible system for the management, visualization and statistical analysis of T-cell receptor spectratype data. Users upload data from their…”
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Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer by Wefald, Franklin C, Devlin, Blythe H, Williams, R. Sanders

“…A regulatory element upstream of the human myoglobin gene functions as a muscle-specific enhancer (MSE) in conjunction with core promoter elements of the…”
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MHC class I restriction in DiGeorge anomaly patients after allogeneic thymus transplantation (141.22) by Li, Bin, Li, Jie, Devlin, Blythe H, Markert, Mary Louise

“…Abstract Purpose: The aim of this study is to determine whether antigen specific T cells are restricted to host or donor MHC after human allogeneic thymus…”
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