Search Results - "Devine, Patrick W"

Early patterning and specification of cardiac progenitors in gastrulating mesoderm by Devine, W Patrick, Wythe, Joshua D, George, Matthew, Koshiba-Takeuchi, Kazuko, Bruneau, Benoit G

“…Mammalian heart development requires precise allocation of cardiac progenitors. The existence of a multipotent progenitor for all anatomic and cellular…”
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A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors by Krup, Alexis Leigh, Winchester, Sarah A B, Ranade, Sanjeev S, Agrawal, Ayushi, Devine, W Patrick, Sinha, Tanvi, Choudhary, Krishna, Dominguez, Martin H, Thomas, Reuben, Black, Brian L, Srivastava, Deepak, Bruneau, Benoit G

“…Transcriptional networks governing cardiac precursor cell (CPC) specification are incompletely understood owing, in part, to limitations in distinguishing CPCs…”
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ETS Factors Regulate Vegf-Dependent Arterial Specification by Wythe, Joshua D., Dang, Lan T.H., Devine, W. Patrick, Boudreau, Emilie, Artap, Stanley T., He, Daniel, Schachterle, William, Stainier, Didier Y.R., Oettgen, Peter, Black, Brian L., Bruneau, Benoit G., Fish, Jason E.

“…Vegf signaling specifies arterial fate during early vascular development by inducing the transcription of Delta-like 4 (Dll4), the earliest Notch ligand gene…”
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Hydra: A mixture modeling framework for subtyping pediatric cancer cohorts using multimodal gene expression signatures by Pfeil, Jacob, Sanders, Lauren M, Anastopoulos, Ioannis, Lyle, A Geoffrey, Weinstein, Alana S, Xue, Yuanqing, Blair, Andrew, Beale, Holly C, Lee, Alex, Leung, Stanley G, Dinh, Phuong T, Shah, Avanthi Tayi, Breese, Marcus R, Devine, W Patrick, Bjork, Isabel, Salama, Sofie R, Sweet-Cordero, E Alejandro, Haussler, David, Vaske, Olena Morozova

“…Precision oncology has primarily relied on coding mutations as biomarkers of response to therapies. While transcriptome analysis can provide valuable…”
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Requirement for chitin biosynthesis in epithelial tube morphogenesis by Devine, W.P, Lubarsky, B, Shaw, K, Luschnig, S, Messina, L, Krasnow, M.A

“…Many organs are composed of branched networks of epithelial tubes that transport vital fluids or gases. The proper size and shape of tubes are crucial for…”
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Genetic ancestry and diagnostic yield of exome sequencing in a diverse population by Mavura, Yusuph, Sahin-Hodoglugil, Nuriye, Hodoglugil, Ugur, Kvale, Mark, Martin, Pierre-Marie, Van Ziffle, Jessica, Devine, W. Patrick, Ackerman, Sara L., Koenig, Barbara A., Kwok, Pui-Yan, Norton, Mary E., Slavotinek, Anne, Risch, Neil

“…It has been suggested that diagnostic yield (DY) from Exome Sequencing (ES) may be lower among patients with non-European ancestries than those with European…”
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A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse by Herman, Alexander M, Rhyner, Alexander M, Devine, W Patrick, Marrelli, Sean P, Bruneau, Benoit G, Wythe, Joshua D

“…Canonical Notch signaling requires the presence of a membrane bound ligand and a corresponding transmembrane Notch receptor. Receptor engagement induces…”
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NTRK fusion cervical sarcoma: a report of three cases, emphasising morphological and immunohistochemical distinction from other uterine sarcomas, including adenosarcoma by Rabban, Joseph T, Devine, W Patrick, Sangoi, Ankur R, Poder, Liina, Alvarez, Edwin, Davis, Jessica L, Rudzinski, Erin, Garg, Karuna, Bean, Gregory R

“…Aims A unique fibrosarcoma‐like tumour of the uterine cervix harbouring a rearrangement of a neurotrophic tyrosine kinase receptor (NTRK) gene (NTRK1 or NTRK3)…”
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Cytoplasmic Pattern p53 Immunoexpression in Pelvic and Endometrial Carcinomas With TP53 Mutation Involving Nuclear Localization Domains: An Uncommon But Potential Diagnostic Pitfall With Clinical Implications by Rabban, Joseph T., Garg, Karuna, Ladwig, Nicholas R., Zaloudek, Charles J., Devine, W. Patrick

“…A cytoplasmic pattern of p53 immunohistochemical expression has recently been reported in a rare subset of pelvic and endometrial cancers with a TP53 mutation…”
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Expanding the phenotype of males with OFD1 pathogenic variants-a case report and literature review by Gangaram, Balram, Devine, W. Patrick, Slavotinek, Anne

“…Pathogenic variants in the OFD1 gene have been classically associated with the Orofaciodigital syndrome type 1 in females, a condition previously considered to…”
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Practical roles for molecular diagnostic testing in ovarian adult granulosa cell tumour, Sertoli–Leydig cell tumour, microcystic stromal tumour and their mimics by Rabban, Joseph T, Karnezis, Anthony N, Devine, W Patrick

“…Within the last decade, molecular advances have provided insights into the genetics of several ovarian sex cord–stromal tumours that have otherwise been…”
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Exome sequencing vs targeted gene panels for the evaluation of nonimmune hydrops fetalis by Norton, Mary E., Ziffle, Jessica Van, Lianoglou, Billie R., Hodoglugil, Ugur, Devine, W. Patrick, Sparks, Teresa N.

“…Next-generation sequencing is increasingly used in prenatal diagnosis. Targeted gene panels and exome sequencing are both available, but the comparative…”
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Next-Generation Sequencing of Retinoblastoma Identifies Pathogenic Alterations beyond RB1 Inactivation That Correlate with Aggressive Histopathologic Features by Afshar, Armin R., Pekmezci, Melike, Bloomer, Michele M., Cadenas, Nicola J., Stevers, Meredith, Banerjee, Anuradha, Roy, Ritu, Olshen, Adam B., Van Ziffle, Jessica, Onodera, Courtney, Devine, W. Patrick, Grenert, James P., Bastian, Boris C., Solomon, David A., Damato, Bertil E.

“…To determine the usefulness of a comprehensive, targeted-capture next-generation sequencing (NGS) assay for the clinical management of children undergoing…”
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Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease by Kathiriya, Irfan S., Rao, Kavitha S., Iacono, Giovanni, Devine, W. Patrick, Blair, Andrew P., Hota, Swetansu K., Lai, Michael H., Garay, Bayardo I., Thomas, Reuben, Gong, Henry Z., Wasson, Lauren K., Goyal, Piyush, Sukonnik, Tatyana, Hu, Kevin M., Akgun, Gunes A., Bernard, Laure D., Akerberg, Brynn N., Gu, Fei, Li, Kai, Speir, Matthew L., Haeussler, Maximilian, Pu, William T., Stuart, Joshua M., Seidman, Christine E., Seidman, J.G., Heyn, Holger, Bruneau, Benoit G.

“…Haploinsufficiency of transcriptional regulators causes human congenital heart disease (CHD); however, the underlying CHD gene regulatory network (GRN)…”
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Effective Use of ALK Inhibitors in EML4::ALK‐Positive Lymphatic Malformations by Apsel Winger, Beth, Dowd, Christopher F., Shimano, Kristin A., Devine, W. Patrick, Mathes, Erin, Frieden, Ilona, Schaefer, Carrie, Kothari, Alok

“…ABSTRACT Genetically targeted medications are emerging as important therapies for lymphatic malformations (LMs) unresponsive to sirolimus. We describe two…”
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Genetic and Immunohistochemical Profiling of Mammary Hidradenoma and Comparison to Mucoepidermoid Carcinoma by Black, Margaret A., Neumann, Neil M., Krings, Gregor, Najjar, Saleh, Troxell, Megan L., Wang, Aihui, Devine, W. Patrick, Vohra, Poonam, Gasper, Cynthia, Chen, Yunn-Yi, Cohen, Jarish N., Bean, Gregory R.

“…Mucoepidermoid carcinoma (MEC) is exceedingly rare in the breast, with <45 cases reported in the literature. Although estrogen receptor/progesterone…”
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Neoadjuvant Osimertinib for the Treatment of Stage I-IIIA Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer: A Phase II Multicenter Study by Blakely, Collin M, Urisman, Anatoly, Gubens, Matthew A, Mulvey, Claire K, Allen, Greg M, Shiboski, Stephen C, Rotow, Julia K, Chakrabarti, Turja, Kerr, D Lucas, Aredo, Jacqueline V, Bacaltos, Bianca, Gee, Megan, Tan, Lisa, Jones, Kirk D, Devine, W Patrick, Doebele, Robert C, Aisner, Dara L, Patil, Tejas, Schenk, Erin L, Bivona, Trever G, Riess, Jonathan W, Coleman, Melissa, Kratz, Johannes R, Jablons, David M

“…To assess the safety and efficacy of the third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor osimertinib as neoadjuvant therapy…”
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Identification of high-risk human papillomavirus and Rb/E2F pathway genomic alterations in mutually exclusive subsets of colorectal neuroendocrine carcinoma by Shamir, Eliah R., Devine, W. Patrick, Pekmezci, Melike, Umetsu, Sarah E., Krings, Gregor, Federman, Scot, Cho, Soo-Jin, Saunders, Tara A., Jen, Kuang-Yu, Bergsland, Emily, Jones, Kirk, Kim, Grace E., Kakar, Sanjay, Chiu, Charles Y., Joseph, Nancy M.

“…Colorectal neuroendocrine carcinomas, both small cell and large cell types, are highly aggressive tumors with poor prognosis compared with colorectal…”
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Tumor and Constitutional Sequencing for Neurofibromatosis Type 1 by Tong, Schuyler, Devine, W Patrick, Shieh, Joseph T

“…variants in tumors are important to recognize, as multiple mechanisms may give rise to biallelic variants. Both deletions and copy-neutral loss of…”
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HER2 overexpression in urothelial carcinoma with GATA3 and PPARG copy number gains by Zhu, Xiaolin, Chan, Emily, Turski, Michelle L, Mendez, Carlos Espinosa, Hsu, Sarah C, Kumar, Vipul, Shipp, Chase, Jindal, Tanya, Chang, Kevin, Onodera, Courtney, Devine, W Patrick, Grenert, James P, Stohr, Bradley A, Ding, Chien-Kuang Cornelia, Stachler, Matthew D, Quigley, David A, Feng, Felix Y, Chu, Carissa E, Porten, Sima P, Chou, Jonathan, Friedlander, Terence W, Koshkin, Vadim S

“…HER2, encoded by the ERBB2 gene, is an important druggable driver of human cancer gaining increasing importance as a therapeutic target in urothelial carcinoma…”
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