Search Results - "Devi, Narra S"

Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma by Dong, Lei, You, Shuo, Zhang, Qing, Osuka, Satoru, Devi, Narra S, Kaluz, Stefan, Ferguson, Jalisa H, Yang, Hua, Chen, Guoliang, Wang, Binghe, Grossniklaus, Hans E, Van Meir, Erwin G

“…Uveal melanoma (UM) is the most prevalent and lethal intraocular malignancy in adults. Here, we examined the importance of hypoxia in UM growth and tested the…”
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Targeting Integrin α3 Blocks β1 Maturation, Triggers Endoplasmic Reticulum Stress, and Sensitizes Glioblastoma Cells to TRAIL-Mediated Apoptosis by Kuranaga, Yuki, Yu, Bing, Osuka, Satoru, Zhang, Hanwen, Devi, Narra S, Bae, Sejong, Van Meir, Erwin G

“…Glioblastoma (GBM) is a devastating brain cancer for which new effective therapies are urgently needed. GBM, after an initial response to current treatment…”
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Vasculostatin, a proteolytic fragment of Brain Angiogenesis Inhibitor 1, is an antiangiogenic and antitumorigenic factor by KAUR, Balveen, BRAT, Daniel J, DEVIL, Narra S, VAN MEIR, Erwin G

“…Brain angiogenesis inhibitor 1 (BAI1) is a transmembrane protein with unknown function expressed primarily in normal but not tumoral brain. The finding of…”
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EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway by Zhang, Hanwen, Zhu, Dan, Zhang, Zhaobin, Kaluz, Stefan, Yu, Bing, Devi, Narra S., Olson, Jeffrey J., Van Meir, Erwin G.

“…Medulloblastoma (MB) is a malignant pediatric brain tumor for which new therapies are urgently needed. We demonstrate that treatment with EPZ-6438…”
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BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation by Zhu, Dan, Osuka, Satoru, Zhang, Zhaobin, Reichert, Zachery R., Yang, Liquan, Kanemura, Yonehiro, Jiang, Ying, You, Shuo, Zhang, Hanwen, Devi, Narra S., Bhattacharya, Debanjan, Takano, Shingo, Gillespie, G. Yancey, Macdonald, Tobey, Tan, Chalet, Nishikawa, Ryo, Nelson, William G., Olson, Jeffrey J., Van Meir, Erwin G.

“…Adhesion G protein-coupled receptors (ADGRs) encompass 33 human transmembrane proteins with long N termini involved in cell-cell and cell-matrix interactions…”
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BRCA1-Associated Protein-1 Is a Tumor Suppressor that Requires Deubiquitinating Activity and Nuclear Localization by VENTII, Karen H, DEVI, Narra S, FRIEDRICH, Kenneth L, CHERNOVA, Tatiana A, TIGHIOUART, Mourad, VAN MEIR, Erwin G, WILKINSON, Keith D

“…BRCA1-associated protein-1 (BAP1), a deubiquitinating enzyme of unknown cellular function, is mutated in breast and lung cancers. In this study, we have shown…”
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Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth by Kaluz, Stefan, Zhang, Qing, Kuranaga, Yuki, Yang, Hua, Osuka, Satoru, Bhattacharya, Debanjan, Devi, Narra S., Mun, Jiyoung, Wang, Wei, Zhang, Ruiwen, Goodman, Mark M., Grossniklaus, Hans E., Van Meir, Erwin G.

“…Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, and patients that develop metastases (~50%) survive <1 year, highlighting…”
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Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase by Kalinina, Juliya, Ahn, Jun, Devi, Narra S, Wang, Liya, Li, Yuancheng, Olson, Jeffrey J, Glantz, Michael, Smith, Thomas, Kim, Ella L, Giese, Alf, Jensen, Randy L, Chen, Clark C, Carter, Bob S, Mao, Hui, He, Miao, Van Meir, Erwin G

“…Elevation in D-2-Hydroxyglutarate (D-2HG) has recently emerged as a mandatory byproduct of mutated Isocitrate Dehydrogenase (IDH) genes 1 and 2 in glioma…”
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A Chimeric Signal Peptide-Galectin-3 Conjugate Induces Glycosylation-Dependent Cancer Cell-Specific Apoptosis by Lee, Sok-Hyong, Khwaja Rehman, Fatima, Tyler, Kari C, Yu, Bing, Zhang, Zhaobin, Osuka, Satoru, Zerrouqi, Abdessamad, Kaluzova, Milota, Hadjipanayis, Costas G, Cummings, Richard D, Olson, Jeffrey J, Devi, Narra S, Van Meir, Erwin G

“…Exploitation of altered glycosylation in cancer is a major goal for the design of new cancer therapy. Here, we designed a novel secreted chimeric signal…”
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Correction: EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway by Zhang, Hanwen, Zhu, Dan, Zhang, Zhaobin, Kaluz, Stefan, Yu, Bing, Devi, Narra S., Olson, Jeffrey J., Van Meir, Erwin G.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP by SHAOMAN YIN, KALUZ, Stefan, ABBRUSCATO, Thomas, ZHENGJIA CHEN, OLSON, Jeffrey J, RUIWEN ZHANG, GOODMAN, Mark M, NICOLAOU, K. C, VAN MEIR, Erwin G, DEVI, Narra S, JABBAR, Adnan A, DE NORONHA, Rita G, MUN, Jiyoung, ZHAOBIN ZHANG, BOREDDY, Purushotham R, WEI WANG, ZHIBO WANG

“…The hypoxia-inducible factor-1 (HIF-1) plays a critical role in tumor adaptation to hypoxia, and its elevated expression correlates with poor prognosis and…”
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Design and Synthesis of Novel Small-Molecule Inhibitors of the Hypoxia Inducible Factor Pathway by Mooring, Suazette Reid, Jin, Hui, Devi, Narra S, Jabbar, Adnan A, Kaluz, Stefan, Liu, Yuan, Van Meir, Erwin G, Wang, Binghe

“…Hypoxia, a reduction in partial oxygen pressure, is a salient property of solid tumors. Hypoxia drives malignant progression and metastasis in tumors and…”
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Vasculostatin Inhibits Intracranial Glioma Growth and Negatively Regulates In vivo Angiogenesis through a CD36-Dependent Mechanism by KAUR, Balveen, CORK, Sarah M, SILVERSTEIN, Roy L, BRAT, Daniel J, OLSON, Jeffrey J, VAN MEIR, Erwin G, SANDBERG, Eric M, DEVI, Narra S, ZHAOBIN ZHANG, KLENOTIC, Philip A, FEBBRAIO, Maria, SHIM, Hyunsuk, MAY, Hui, TUCKER-BURDEN, Carol

“…Angiogenesis is a critical physiologic process that is appropriated during tumorigenesis. Little is known about how this process is specifically regulated in…”
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Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors by Tan, Chalet, de Noronha, Rita G., Devi, Narra S., Jabbar, Adnan A., Kaluz, Stefan, Liu, Yuan, Mooring, Suazette Reid, Nicolaou, K.C., Wang, Binghe, Van Meir, Erwin G.

“…Solid tumors generally grow under hypoxic conditions, a pathophysiological change, which activates the expression of genes responsible for malignant,…”
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A NOVEL P53 BYSTANDER EFFECT INDUCES GLIOBLASTOMA CELL DEATH THROUGH A GLYCOSYLATION-DEPENDENT MECHANISM by Van Meir, E. G., Lee, S.-H., Khwaja, F. W., Zerrouqi, A., Zhang, Z., Olson, J. J., Kaluzova, M., Hadjipanayis, C. G., Devi, N. S.

“…BACKGROUND: Mutations in the TP53 tumor suppressor gene are required for the development of many malignancies, including brain tumors. Yet, the molecular…”
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Abstract 1996: Epigenetic reactivation of BAI1/ADGRB1 suppresses tumor invasion by preventing TGFβ1-induced mesenchymal switch in glioblastoma by Osuka, Satoru, Yang, Liquan, Zhu, Dan, Hashimoto, Hideharu, Devi, Narra S., Meir, Erwin G. Van

“…Abstract Glioblastoma (GBM) is the most common and lethal type of malignant brain tumor in adults. GBM cells are highly invasive and diffusely infiltrate…”
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EZH2 targeting in medulloblastoma reduces tumor growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway by Zhang, Hanwen, Zhu, Dan, Zhang, Zhaobin, Kaluz, Stefan, Yu, Bing, Devi, Narra S., Olson, Jeffrey J., Van Meir, Erwin G.

“…Medulloblastoma is a malignant pediatric tumor for which new therapies are urgently needed. We demonstrate that treatment with EPZ-6438 (Tazemetostat), an…”
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Abstract 1296: Arylsulfonamide KCN1 suppresses primary and metastatic growth of uveal melanoma through anti-angiogenic and anti-invasion mechanisms by Kaluz, Stefan, Zhang, Qing, Yang, Hua, Osuka, Satoru, Mun, Jiyoung, Devi, Narra S., Goodman, Mark, Grossniklaus, Hans E., Meir, Erwin G. Van

“…Abstract Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults with a survival time less than 1 year for patients that develop…”
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A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1 by Cork, S M, Kaur, B, Devi, N S, Cooper, L, Saltz, J H, Sandberg, E M, Kaluz, S, Van Meir, E G

“…Brain-specific angiogenesis inhibitor 1 (BAI1), an orphan G protein-coupled receptor-type seven transmembrane protein, was recently found mutated or silenced…”
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Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with co-factors p300/CBP by Yin, Shaoman, Kaluz, Stefan, Devi, Narra S., Jabbar, Adnan A., de Noronha, Rita G., Mun, Jiyoung, Zhang, Zhaobin, Boreddy, Purushotham R., Wang, Wei, Wang, Zhibo, Abbruscato, Thomas, Chen, Zhengjia, Olson, Jeffrey J., Zhang, Ruiwen, Goodman, Mark M., Nicolaou, K.C., Van Meir, Erwin G.

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