Search Results - "Devereaux, Erik"

Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer by Hwang, Rosa F, Moore, Todd T, Hattersley, Maureen Mertens, Scarpitti, Meghan, Yang, Bin, Devereaux, Erik, Ramachandran, Vijaya, Arumugam, Thiruvengadam, Ji, Baoan, Logsdon, Craig D, Brown, Jeffrey L, Godin, Robert

“…The Hedgehog (Hh) pathway has emerged as an important pathway in multiple tumor types and is thought to be dependent on a paracrine signaling mechanism. The…”
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Abstract 6639: SRF617, a potent enzymatic inhibitor of CD39, demonstrates single-agent activity and cooperates with various cancer therapies in both solid tumor and hematologic malignancies by Das, Sonia G., Dulak, Austin, Tan, Gege, Johnson, Marc, Zaidi, Tauqeer H., Warren, Michael C., Koseoglu, Secil, Devereaux, Erik, Peluso, Marisa O., Paterson, Alison M., Lee, Benjamin H., Palombella, Vito J., Holland, Pamela M., Lake, Andrew C.

“…Abstract CD39 (ENTPD1) is a key enzyme responsible for the degradation of extracellular adenosine triphosphate (ATP) and is upregulated in the tumor…”
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The B Cell Receptor Antagonist R406 Alters The Balance Between Anti-Apoptotic and Pro-Apoptotic Signals To Strongly Synergize With ABT-199 In Diffuse Large B Cell Lymphoma Cells by Zhang, Yue, Francoise, Powell, Devereaux, Erik, Passino, Melissa, Parmentier, Julie, Byth, Kate

“…SYK plays an essential role in B cell receptor (BCR) mediated survival in Diffuse Large B Cell Lymphoma (DLBCL). In a previous clinical investigation,…”
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SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties by Warren, Michael C, Matissek, Stephan, Rausch, Matthew, Panduro, Marisella, Hall, R J, Dulak, Austin, Brennan, David, Das Yekkirala, Sonia, Koseoglu, Secil, Masia, Ricard, Yang, Yu, Reddy, Navamallika, Prenovitz, Robert, Strand, Jamie, Zaidi, Tauqueer, Devereaux, Erik, Foissac, Célia Jacoberger, Stagg, John, Lee, Benjamin H, Holland, Pamela, Palombella, Vito J, Lake, Andrew C

“…CD39 (ENTPD1) is a key enzyme responsible for degradation of extracellular ATP and is upregulated in the tumor microenvironment (TME). Extracellular ATP…”
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Spleen Tyrosine Kinase Inhibitor Fostamatinib Blocks B Cell Receptor Signaling and Reduces Viability of BCR Subtype Diffuse Large B Cell Lymphoma by Zhang, Yue, Parmentier, Julie, Lai, Zhongwu, O'Connor, Greg, Passino, Melissa, Powell, Francoise, Devereaux, Erik, Byth, Kate

“…Abstract 3720 Spleen tyrosine kinase (SYK) plays a key role in B cell receptor mediated survival in certain B cell malignancies including Diffuse Large B Cell…”
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Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases by Wang, Tao, Block, Michael A., Cowen, Scott, Davies, Audrey M., Devereaux, Erik, Gingipalli, Lakshmaiah, Johannes, Jeffrey, Larsen, Nicholas A., Su, Qibin, Tucker, Julie A., Whitston, David, Wu, Jiaquan, Zhang, Hai-Jun, Zinda, Michael, Chuaqui, Claudio

“…The design, synthesis and biological evaluation of a series of azabenzimidazole derivatives as TBK1/IKKε kinase inhibitors are described. Starting from a lead…”
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Discovery of 6-aryl-azabenzimidaoles that inhibit the TBK1/IKK-ε kinases by Johannes, Jeffrey W., Chuaqui, Claudio, Cowen, Scott, Devereaux, Erik, Gingipalli, Lakshmaiah, Molina, Audrey, Wang, Tao, Whitston, David, Wu, Xiaoyun, Zhang, Hai-Jun, Zinda, Michael

“…The discovery and optimization of a series of 6-aryl-azabenzimidazole inhibitors of TBK1 and IKK- epsilon is described. Various internal azabenzimidazole leads…”
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Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO by Yang, Bin, Hird, Alexander W., Russell, Daniel John, Fauber, Benjamin P., Dakin, Les A., Zheng, Xiaolan, Su, Qibin, Godin, Robert, Brassil, Patrick, Devereaux, Erik, Janetka, James W.

“…Cell-based subset screening of compounds using a Gli transcription factor reporter cell assay and shh stimulated cell differentiation assay identified a series…”
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Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-ε kinases by Johannes, Jeffrey W, Chuaqui, Claudio, Cowen, Scott, Devereaux, Erik, Gingipalli, Lakshmaiah, Molina, Audrey, Wang, Tao, Whitston, David, Wu, Xiaoyun, Zhang, Hai-Jun, Zinda, Michael

“…The discovery and optimization of a series of 6-aryl-azabenzimidazole inhibitors of TBK1 and IKK-ε is described. Various internal azabenzimidazole leads and…”
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